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Doctor insights on: How Long Will It Take For Prozac To Leave My System

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Dr. Heidi Fowler
1,057 Doctors shared insights

Fluoxetine (Definition)

Fluoxetine (brand prozac) is an antidepressant in the class known as serotonin selective reuptake inhibitors aka ssris. Fda approved in 1987 for the treatment of major depressive disorder. Subsequently approved for obsessive compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Significantly safer and much better ...Read more


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How long would it take for 5mg of Prozac (fluoxetine) to leave my system if I've been taking it for 5 weeks?

How long would it take for 5mg of Prozac (fluoxetine) to leave my system if I've been taking it for 5 weeks?

Prozac (fluoxetine): Is sometimes used on a temporary basis to minimize the affects of coming off other SSRI agents (yes there are SSRI withdrawal symptoms) Prozac (fluoxetine) is typically given in the 10-20 mg dose for this purpose for a 7-14 days. At 5 mg discontinuation after 5 weeks would require about 5-8 days. (depending on renal function) ...Read more

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How long does it take for Prozac (fluoxetine) to leave your system completely after discontinued?

How long does it take for Prozac (fluoxetine) to leave your system completely after discontinued?

Apprx. 20 days: Prozac (fluoxetine) is a long acting medicine, between the original compound and the active metabolite the half life is around 96 hrs, so it takes approximately five times that for the level to drop to negligible. ...Read more

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Started Prozac (fluoxetine) 2 months ago. Weight up about 2 lbs with no lifestyle change. Heart, kidney, liver ok. Is this probably Prozac (fluoxetine)? Or normal variation?

Started Prozac (fluoxetine) 2 months ago. Weight up about 2 lbs with no lifestyle change. Heart, kidney, liver ok. Is this probably Prozac (fluoxetine)? Or normal variation?

Not necessarily: When people are depressed they frequently have poor appetite and lose weight. So it stands to reason when their treatment (in this case the effect of Prozac (fluoxetine)) begins to work they may regain their appetite and start to gain weight. There are other potential reasons for gaining weight so this should be a topic of discussion with your doctor. ...Read more

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I took Prozac 10mg for two days. How long will it take to get out of my system?

I took Prozac 10mg for two days. How long will it take to get out of my system?

Up to 5 wks: It is difficult to determine the exact duration prozac will stay in the system, because people metabolize prozac at different rates. The longest it would probably stay in the system is 5 wks, (this is the "safe" washout time when there is no risk for drug interaction with MAO inhibitors.). Prozac has a half life of 7-9 days (pretty large margin there). but that does not mean it is out in 14-18 d. ...Read more

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Took 5mg of Prozac (fluoxetine) for 6 days. How many days would it take to leave my system?

Took 5mg of Prozac (fluoxetine) for 6 days. How many days would it take to leave my system?

Less than a week: The usual starting dose for fluoxetine (Prozac) is 20 mg, so you were on a VERY low dose, so after 6 doses there is not very much med in your body. The time for 1/2 the medicine to be eliminated from the body in a healthy person is 3 days at most, so it would take about 6 days for the last dose to be completely eliminated. It may be gone sooner depending on how quickly your liver metabolizes it. ...Read more

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How long approximately does it take for Prozac (fluoxetine) to get out of your system totally?

Prozac (fluoxetine): Has half-life of up to 72 hours, so that multiplied by 5 means that it can stay in your system for up to 2 weeks or so. ...Read more

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I took 20mg of Prozac (fluoxetine) for 4 days. I have been off of it for 3 days. How long does it take to get out of my system?

A while: Since you took prozac/fluoxetine for only 4 days, it should leave your system in about 1 - 2 weeks completely. In general, if someone has been taking Prozac for a while (longer than two weeks), it can take up to 5 weeks to completely wash it out of ones system. For side effects (or beneficial effects) to go away, Prozac does not have to wash out completely, just be low enough to not affect you. ...Read more

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How long does 10mg of Prozac (fluoxetine) take to get into your blood system to feel effects?

How long does 10mg of Prozac (fluoxetine) take to get into your blood system to feel effects?

Prozac (fluoxetine): The time to onset of action of an antidepressant, including prozac, (fluoxetine) depends upon a number of factors including the condition being treated. That being said, you can generally expect one to two weeks to start to notice the clinical effect and 4-6 weeks to safely evaluate the full effect of any particular dose in the treatment of depression. Side effects, if present, can be experienced sooner. ...Read more

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I only took it for 3 days, so how long will it stay in my system. Prozac (fluoxetine) 20 mg. Also can I safely take my tramadol?

Prozac (fluoxetine): Prozac (fluoxetine)'s half life is up to 6-7 days but if you only took 3 doses, you didn't get much into you system. Trauma sol interacts with Prozac (fluoxetine) like drugs. It can increase the risk for the serotonin syndrome. If you are off Prozac (fluoxetine) 3 days you should be able to take tramadol. It is unlikely it would occur at your dose and duration ...Read more

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How long does it take to get Lyrica, (pregabalin) Prozac and Lorazapam out my system safely before getting pregnant?

How long does it take to get Lyrica, (pregabalin) Prozac and Lorazapam out my system safely before getting pregnant?

Planning a pregnancy: If you were prescribed these meds by your doc, they must be for a medical condition (depression? anxiety? fibromyalgia?). Its very important that you discuss your plans to become pregnant, the right way to come off your meds, and the proper way to treat your condition so you can have a healthy pregnancy. Ask your doc when it would be safe to start trying to conceive :) ...Read more

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I took 20mg of Prozac (fluoxetine) for 4 days I have been off of it for 6 days How long does it take to get out of my system? I've had heart palpitations all day

2-4 weeks: Half-life of prozac (fluoxetine) is about 3 days, multiply it by 5, it is about 2 weeks to bring Prozac (fluoxetine) blood concentration to a barely detectable level... but to avoid any drug-to-drug interactions, I'd advice to wait for 4 weeks. ...Read more

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How long does it take for Prozac (fluoxetine) to leave the body?

How long does it take for Prozac (fluoxetine) to leave the body?

About a week: There's 2 related questions here. It takes about a week for fluoxetine (prozac) to leave the body after dosing has stopped. This is longer than other antidepressants. But all antidepressants, including prozac, continue to have an effect on mood for 2-3 weeks after they're stopped. The brain effect persists a couple weeks even after the drug is gone. ...Read more

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How long does Prozac (fluoxetine) stay in your system?

More than 2 weeks: The half life of this medication is as long as three days. It will be out of your system in 15 days depending on individual factors related to the patient. Ask your prescriber. ...Read more

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How long before 3 doses of Prozac (fluoxetine) outvof system?

4 to 5 weeks: Prozac (fluoxetine) has a half life of 7 days and it takes at least 4 half lifes or more to clear your body. ...Read more

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How long does Prozac (fluoxetine) have to be in your system before it starts to work?

Prozac (fluoxetine): Like other antidepressants, Prozac (fluoxetine) generally requires at least 4-6 weeks' consistent dosing for therapeutic effectiveness. You may experience some benefit before this, however. ...Read more

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How long does a higher dose of Prozac (fluoxetine) start to get into your system. (Went from 50-60 since Friday)?

Several days: Within 3-5 days I'd expect the higher dose to be stabilizing in your bloodstream. Whether or not that translates into clinical effects for the purpose your doctor prescribed it though is a different story since there may be much more lag time for the body to RESPOND to a medication or its increase than, for the substance to actually get to measurably higher/stable levels. Make sense? ...Read more

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Been off Prozac (fluoxetine) for 7 days. Was on 20mg for 5days. When will it leave my system? What effects will happen during the time?

Not much: Prozac (fluoxetine) is a long acting medication, if you have taken for 5 days only it should be out of your system soon even though some metabolites linger on for few weeks. You should not see any problems coming off of it. ...Read more

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My dr. Lowered my dose of Prozac (fluoxetine) from 20mg to 10mg. Because of the half life does this mean I will have more in my system and if so for how long?

Prozac (fluoxetine): Yes Prozac (fluoxetine) has a longer half life of approximately 5-7 days, eliminated usually in several weeks. Because of this yes, dose adjustments may delay change in symptoms if doing so for side effect reasons. ...Read more

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Took 400mg of sam -e for 10 days. How long does this stay in your system. Want to stop it and go back to 10mg of prozac (fluoxetine)?

Took 400mg of sam -e for 10 days. How long does this stay in your system. Want to stop it and go back to 10mg of prozac (fluoxetine)?

Depression: You need to consult with your doctor as I have seen negative effects of going between sam-e and prozac (fluoxetine). Sam-e is difficult to assess as to its quality as it is not regulated. Be honest with your doctor as to your dose so you can make the adjustment with the least consequences. Best wishes. ...Read more

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Been on Prozac (fluoxetine) for 5 days at 20mg. Doc said to stop. How long before leaves my system?

Prozac (fluoxetine) elimination: Prozac has an elimination half-life of 70 hours, with its active metabolite (norfluoxetine) at 330 hours. That means it will take 70 x 5 = 350 hours (or a little over 2 weeks) for fluoxetine to be gone from your system. It will take much, much longer for norfluoxetine to be eliminated also. ...Read more

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Took Prozac (fluoxetine) 10 mg for 2 weeks, was extremely tired and feeling cold, have not taken it for the past 5 days. How long until it is out of my system?

Took Prozac (fluoxetine) 10 mg for 2 weeks, was extremely tired and feeling cold, have not taken it for the past 5 days. How long until it is out of my system?

Two weeks to clear: It usually takes prozac (fluoxetine) two weeks to clear from the body. In your case, the prozac (fluoxetine) should be gone in about 9 more days. Hope this helps. Best wishes! ...Read more

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I took Prozac (fluoxetine) for nearly 2.5 years. Have been weaned off by psychiatrist & just stopped yesterday. How long before it leaves my system completely?

20-30 days: The half-life is 4-6 days with chronic use. We multiply that by 5 to get the elimination half-life which would then be 20-30 days. There are metabolizes that can hang around longer. ...Read more

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How long will it take for Prozac (fluoxetine) to begin working?

Prozac (fluoxetine): Usually after one week you would see some response, then within 4-5 weeks for full efficacy at the therapeutic dose. ...Read more

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I am switching from Prozac (80mg) to Effexor (225mg). How long will it take to get fully adjusted to Effexor?

I am switching from Prozac (80mg) to Effexor (225mg). How long will it take to get fully adjusted to Effexor?

Your doctor is the g: Your best guide is your doctor who gave you the medicine. Did you ask him this very appropriate question? If not call him/her up and request this info.
As far as I can tell you, a change in an antidepressant should have its full effects in 2 to 3 weeks. ...Read more

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Tried lamictal as mood stabilizer was up to 50 mg at 3 weeks with intense itching my md told me to quit it today and raised my Prozac (fluoxetine) from 10 mg to 20mg how long will it take for itching to stop?

Tried lamictal as mood stabilizer was up to 50 mg at 3 weeks with intense itching my md told me to quit it today and raised my Prozac (fluoxetine) from 10 mg to 20mg how long will it take for itching to stop?

Lamictal & itch?: lamictal can cause a rash (SJS) that may be severe enough 2 b fatal. More common, any new med can cause a benign, but annoying rash (sometimes preceded by itch). bc there is a small chance that lamictal may cause the dangerous rash, MDs wisely stop the med if ANY new rash (or rash-like sx) develops. When will it pass? Us. days. Best way 2 know is have a dermatologist biopsy - 2 determine if SJS ...Read more

Dr. Alan Ali
778 Doctors shared insights

Prozac (Definition)

Prozac is a serotonin reuptake blocker which is a kind of ...Read more