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Doctor insights on: How Long Should Neuroleptic Malignant Syndrome Last

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Do I need to report neuroleptic malignant syndrome as a long-term health condition, or does it go away after being treated?

Do I need to report neuroleptic malignant syndrome as a long-term health condition, or does it go away after being treated?

Yes, let doctor know: Even though a previous occurrence of nms has resolved, it may recur, especially if the causative agent, or one similar to it, is administered again. Let doctor know, so that a similar medication can be safely avoided.

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Dr. John Moranville
359 Doctors shared insights

Antipsychotics (Definition)

These are medications used among other things to treat psychosis. There are two poorly named classes: the typicals, because they used to be typically used, and the atypicals, which are now typically used. They differ in that the so called atypicals are non-neuroleptics and interact with both serotonin and Dopamine receptos, while the typicals ...Read more


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What causes neuroleptic malignant syndrome?

NMS: Neuroleptics (antipsychotics) block certain Dopamine receptors in the hypothalamus (hypothalamic d-2 receptors) resulting in an elevated temperature set point and  impairment of the bodies ability to dissipate heat; it is also associated with blockade of other Dopamine receptors, which can  result in muscle rigidity and increased body temperature..

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How do you treat neuroleptic malignant syndrome?

Supportive: Mainly supportive treatment by controlling blood pressure, oxygenation, cardiac irregularity, electrolyte water balance, seizure treatment. Some drugs are used that seem to be helping.

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Who is at risk of neuroleptic malignant syndrome?

NMS: Can occur in anyone exposed to a neuroleptic/ drug blocker d2 (dopamine receptos). Although it can occur at any time during treatment it is more common after starting the medication or increasing the dose. It is very rare with  an incidence of 0.07-0.2%. Men are at greater risk than women. Other risk factors include  history of nms, increased environmental temperature,  dehydration,  agitation.

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Can you please define neuroleptic malignant syndrome?

NMS: Neuroleptic malignant syndrome (nms) is a rare, but life-threatening, idiosyncratic reaction to a neuroleptic (antipsychotic) medication. The syndrome is characterized by fever, muscular rigidity, altered mental status, and autonomic dysfunction.

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How to tell if I have neuroleptic malignant syndrome?

You don't.: Nms is so severe that you will not be asking questions. Google can be good resource if you need to know more.

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What are the tests for neuroleptic malignant syndrome?

What are the tests for neuroleptic malignant syndrome?

Several!: Neuroleptic malignant syndrome is a diagnosis of exclusion, so we have to make sure there isn't another problem like an infection. Blood count may show high white blood cells, urine test may have myoglobin. If tests like blood and urine culture show no signs of infection, ct/mri of the head show no brain problems and the patient is on or has taken an antipsychotic this points us towards nms.

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Is the neuroleptic malignant syndrome really malignant?

Is the neuroleptic malignant syndrome really malignant?

NO!: Neuroleptic malignant syndrome (nms) is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Nms typically consists of muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium, and is associated with elevated plasma creatine phosphokinase.

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What are the symptoms of neuroleptic malignant syndrome?

What are the symptoms of neuroleptic malignant syndrome?

Fever, stiff muscles: Fever, stiff muscles, changes in personality and thinking, and autonomic instability (racing heart, low or high blood pressure, sweating, leaking urine...) are symptoms of neuroleptic malignant syndrome. This is a very serious and life-threatening reaction to treatment with antipsychotic medications or withdrawal from certain medications.

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Could you explain what is neuroleptic malignant syndrome?

Complicated: "life-threatening condition that may develop anytime during therapy with neuroleptics—from a few days to many years (but 2/3 of cases occur within the 1st week). Muscular rigidity from Dopamine antagonism in the nigrostriatal pathway. Hyperthermia due to blockage of hypothalamic thermoregulation (more likely in the setting of benzodiazepine withdrawal)" from lexi drugs.

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What are the best home remedies for neuroleptic malignant syndrome?

None that I know of!: Real neuroleptic malignant syndrome is not a condition for home remedies. It is related to medications and is a very serious condition which almost always requires treatment in the hospital to manage the fever, unstable blood pressure, muscle rigidity, and other problems that are characteristic of this syndrome. The medication that caused nms to develop must be identified and stopped.

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I need to know what is neuroleptic malignant syndrome and is it cureable?

Life threatening.: It is a life threatening condition that can develop while on antipsychotic medications and will manifest with high fever, sweating, stupor and muscle rigidity. It can be fatal but outcome is good if early detection and intensive care is accorded.

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What is the definition or description of: Neuroleptic malignant syndrome?

Rare & Dangerous: Neuroleptic malignant syndrome is a rare, potentially life-threatening disorder usually caused by an unpredictably bad reaction to an antipsychotic drug. Typically there is muscle rigidity, fever, unstable pulse and blood pressure, mental impairments and characteristic laboratory changes. Treatment relies on stopping the drug and supportive hospital care.

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Of all the health problems, why would I get neuroleptic malignant syndrome?

Of all the health problems, why would I get neuroleptic malignant syndrome?

Drugs: You may get this syndrome due to a genetic predisposition, usually unknown to you, upon receiving certain medications. Some of these medicines are used to treat nausea, stomach motility problems or emotional and psychiatric problems. Always tell your doctor if anyone in your family had adverse neurologic problems with medication.

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Can you tell me how are you supposed to treat neuroleptic malignant syndrome?

Complicated: This should be done by medical professionals. Correct diagnoses is also very important. There are no specific medication. Every case is different.

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What is neuroleptic malignant syndrome? Is it treatable?

NMS: Neuroleptic malignant syndrome is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs (ex: haldol, (haloperidol) droperidol). NMS typically consists of muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium, and is associated with elevated CPK.

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What does it mean by "rarely causes a serious condition called neuroleptic malignant syndrome"?

No: That is not cancer but a drug reaction syndrome that causes fever, muscle destruction, hypermetabolism and is very dangerous. But it is not cancer.

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Does Abilify (aripiprazole) causes neuroleptic malignant syndrome?

Possible with med: Abilify/aripiprazole is an antipsychotic medication that has the potential to cause the rare but possibly life-threatening condition known as neuroleptic malignant syndrome (nms). Nms usually results from combining multiple antipsychotics (abilify plus others) in high dose all at once which overwhelms the body: muscle rigidity/fever/neurologic instability; unlikely to happen if take as prescribed.

Dr. Scott Mackinnon
86 Doctors shared insights

Neuroleptic Malignant Syndrome (Definition)

Neuroleptic malignant syndrome is a rare, potentially life-threatening disorder usually caused by an unpredictably bad reaction to an antipsychotic drug. Typically there is muscle rigidity, fever, unstable pulse and blood pressure, mental impairments and characteristic laboratory changes. Treatment relies on stopping the drug ...Read more


Malignant (Definition)

The term “malignant” is mainly used in the context of cancer, but can also be used to describe a condition that can be acutely damaging to the body, ...Read more