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Doctor insights on: How Long For Zoloft To Leave Your System

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Does Zoloft have bad side affects long term? Like kidney ,heart, liver disease?

Does Zoloft have bad side affects long term? Like kidney ,heart, liver disease?

Few side effects: Zoloft (sertraline) is an antidpressant SSRI that rarely can lead to inflammation of the liver or other allergic reactions. Main side effect occurs with sudden withdrawal (reduce dosage gradually) or the so-called "serotonin syndrome" if taken with other drugs that increase the likelihood of this side effect. ...Read more

Dr. Heidi Fowler
1,076 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Is Zoloft (sertraline) bad for my liver?

Is Zoloft (sertraline) bad for my liver?

Probably Not: Although metabolized by the liver, zoloft (sertraline) is one of the milder antidepressants on the liver. If you are very concerned you can ask your doc to check your liver enzymes. ...Read more

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Im 16 male and have overdosed 3 times on zoloft (sertraline). Im getting scared that my life may be in danger due to liver damage. Pleas help?

Im 16 male and have overdosed 3 times on zoloft (sertraline). Im getting scared that my life may be in danger due to liver damage. Pleas help?

Major Depression: I understand your distress. It seems that stresses have made you very depressed and hopeless. You were born with the Blessing and Wonder of Life Force and Breath of Life due to which you are alive today. Liver damage is not a common side effect of Zoloft (sertraline). See GI Specialist for liver status. See Psychiatrist for Diagnosis; discuss Inpatient Psychiatric Treatment You are a precious Human Being! ...Read more

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Im taking Zoloft (sertraline) 75, can it cause liver enzymes higher?

Im taking Zoloft (sertraline) 75, can it cause liver enzymes higher?

Transaminases: can go up a bit. If your bilirubin is up or your albumen drops you need to discuss this with your doctor. ...Read more

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Hi, My boyfriend has a fatty liver and his doctor has prescribed him sertraline (zoloft) for anxiety how big of a risk will this affect his liver?

Hi, My boyfriend has a fatty liver and his doctor has prescribed him sertraline (zoloft) for anxiety how big of a risk will this affect his liver?

Minimal probable: Depending on the severity of your BF's liver disease, the medication Sertraline should be ok, but his Liver function tests should be monitored periodically as a precaution. Best wishes. ...Read more

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I'm taking Zoloft (sertraline) 200, lamictal 200 and olanzapine 10 for the last 2 years, it was lower before that, can it cause liver damage, or other dangerous things?

I'm taking Zoloft (sertraline) 200, lamictal 200 and olanzapine 10 for the last 2 years, it was lower before that, can it cause liver damage, or other dangerous things?

No: If you are taking your meds as prescribed, ; your liver is functioning normally, it should be O.K. If you are started on Depakote or depakene, (valproic acid) you may need to have the Lamictal reduced or started on those meds at a very low dose, as it can cause Lamictal levels to be increased by 50% in your system. ...Read more

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I have 3 prescriptions. Zoloft, Nexium (esomeprazole) and clonazepam. Are any of these hard on or dangerous to your liver?

I have 3 prescriptions.  Zoloft, Nexium (esomeprazole) and clonazepam.  Are any of these hard on or dangerous to your liver?

All three of these: medications are broken down by your liver. If your liver is normal it should not be dangerous. ...Read more

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Is it ok to take seroquel xr, Zoloft (sertraline) and liver tone plus tablet at night so you would not get that hangover filling in the morning.

Is it ok to take seroquel xr, Zoloft (sertraline) and liver tone plus tablet at night so you would not get that hangover filling in the morning.

Hangover?: If having a hangover feeling after taking your prescribed medications at night, your dose may need adjusting -- especially the seroquel (quetiapine). I suggest discussing what you're experiencing with your doctor, since s/he may be able to help you solve the problem without additional supplements. Livatone plus has milk thistle in it -- and studies of interactions w/medications are equivocal. ...Read more

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Looking for a safe combo, antipsychotic with 100 mg Zoloft (sertraline) daily - slightly sensitive liver cannot take lithium or Depakote (dizziness, low bp)?

Looking for a safe combo, antipsychotic with 100 mg Zoloft (sertraline) daily - slightly sensitive liver cannot take lithium or Depakote (dizziness, low bp)?

Abilify (aripiprazole) both: Augments the antidepressant effect of zoloft and treats the psychosis. I would start there. Dose will need to be slightly lowered because zoloft can raise Abilify (aripiprazole) levels. I also find that it has very good results in ptsd. My Next Choice would be seroquel. Discuss dosing with your psychiatrist and make sure you are definitely not bipolar. ...Read more

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Accidentally give my liver too much? Had 1/4 glass of wine. Then 3 hrs later, not thinking, took a Benadryl (diphenhydramine) for allerg and 25 mg of prs Zoloft for anx

Accidentally give my liver too much? Had 1/4 glass of wine. Then 3 hrs later, not thinking, took a Benadryl (diphenhydramine) for allerg and 25 mg of prs Zoloft for anx

Liver likely ok: Although alcohol, Benadryl (diphenhydramine), and Zoloft (sertraline) are all broken down by the liver, the quantities you mention shouldn't be a problem for an otherwise healthy liver. But I'm a little concerned if you take Zoloft "prn" (as needed) for anxiety. It doesn't work well that way, although it can relieve anxiety if taken daily. Talk to your prescribing doctor about this. ...Read more

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How long does it take for Zoloft (sertraline) to leave your system after you stop taking it?

How long does it take for Zoloft (sertraline) to leave your system after you stop taking it?

5 days: 1/2 life is 1 day, 5 half life's to clear. Assuming you are a normal metabolier 5 days would pretty much do it. ...Read more

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How long can Zoloft (sertraline) take to get out of your system?

Male or woman: Depends. Its half life is long. Average is considered about 24 hours just to get half of it out of your body. It may be 1.5 times longer in women. And, remember, the next 24 hours just gets half of the remaining half out of you. ...Read more

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Does Zoloft (sertraline) leave permanent 'marks' on your brain? Even if you stopped taking it will your brain be any different once its out of your system?

NO: Zoloft (sertraline) , antidepressants in general, leave no telltale "marks" on common imaging studies (ct, mri) there maybe brief changes in certain receptors, but this would require very sophisticated imaging that would only be used in a research trial. Over time receptors are "recycled", it is doubtful that the new receptors would show evidence of medication use. ...Read more

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I took 20mg of prednisone and my anxiety went through the roof. I'm on zoloft (sertraline) for anxiety. How long until it is out of my system. Before pred, no prob?

I took 20mg of prednisone and my anxiety went through the roof. I'm on zoloft (sertraline) for anxiety. How long until it is out of my system. Before pred, no prob?

A day or two: The prednisone is cleared over the course of a couple of days (half-life about 3 hours). The undo anxiety should abate as the level decreases. It is often difficult to predict which patients will suffer this side effect, but most do to at least some extent. Pre-existing anxiety is certainly a risk factor. ...Read more

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Dr. Alan Ali
1,031 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more