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Doctor insights on: How Long Does Wellbutrin Stay In Your System

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I've been off of my wellbutrin (bupropion) for 2 weeks now. Got refill, is it still in my system and how long until i feel better again?(450 mgs)

I've been off of my wellbutrin (bupropion) for 2 weeks  now. Got refill, is it still in my system and how long until i feel better again?(450 mgs)

2-3 days to 8wks: Although most symptoms subside within a few days, some may continue for 8 weeks or more and require medical attention. Early intervention greatly improves treatment and control of symptoms due to withdrawal. With proper medical advice, discontinuing wellbutrin (bupropion) is safe. Most people experience mild symptoms that last for a few days while the body readjusts. Expert insight. ...Read more

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Dr. Alan Ali
758 doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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I took wellbutrin (bupropion) for 7yrs.Been off for 4mnths.Can i take it on days that i feel overly anxious? Will it work, or does it have to be in system longer?

I took wellbutrin (bupropion) for 7yrs.Been off for 4mnths.Can i take it on days that i feel overly anxious? Will it work, or does it have to be in system longer?

Get an evaluation: Sounds like you might need another assessment of your symptoms so you can get an accurate diagnosis and treatment. It is not recommended in most cases to take wellbutrin (bupropion) on an as needed basis. ...Read more

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I took wellbutrin for 2days 1xa day 150mg its making worse how long till out of system and can try something else want to try inderal .

3-5 days: If you were only taking wellbutrin for 2 days just to be safe I'd wait 3-5 days before starting inderal under your PCP direction naturally, but usually 2 days of a med like wellbutrin would have minimal adverse effects if any stopping it abruptly as you have done. having said that any med changes should be closely monitored by you primary care provider. ...Read more

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Does wellbutrin (bupropion) have an effect on a woman's reproductive system?

Not directly: Unlike many other antidepressants which can decrease libido and/or sexual performance wellbutrin (bupropion) is more likely to increase interest in sexual activity and in males is less likely to cause impotence. ...Read more

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I'm taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take a vyvanse with these medications in my system?

I'm taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take a vyvanse with these medications in my system?

Caution: You already have significant drug interactions with the 3 meds listed. Adding Vyvanse plus Wellbutrin (bupropion) increases risk for seizures. Vyvanse plus Lexapro increases side effects of Vyvanse and risk for serotonin syndrome. Review these meds with prescribing doctor. You need close medical supervision to take these medications. I hope this helps. ...Read more

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How long should it take to stop taking wellbutrin (bupropion)?

Are you asking: How long you need to take for a specific condition or are you asking how to taper off it. What is the condition being treated? Please clarify and re-ask. Thank you. ...Read more

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Anyone have problems with long term wellbutrin (bupropion) use?

Generally no: Wellbutrin (bupropion) as a long term medication to treat and prevent major depression is generally safe and does not cause any known harm. ...Read more

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How long it takes to feel better when taking wellbutrin (bupropion) xl?

2 weeks: most psychiatric medication takes about two weeks to start showing any change in individuals. ...Read more

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Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more