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Doctor insights on: How Long Does Wellbutrin Stay In Your System

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I've been off of my wellbutrin (bupropion) for 2 weeks now. Got refill, is it still in my system and how long until I feel better again? (450 mgs)

I've been off of my wellbutrin (bupropion) for 2 weeks now. Got refill, is it still in my system and how long until I feel better again? (450 mgs)

2-3 days to 8wks: Although most symptoms subside within a few days, some may continue for 8 weeks or more and require medical attention. Early intervention greatly improves treatment and control of symptoms due to withdrawal. With proper medical advice, discontinuing wellbutrin (bupropion) is safe. Most people experience mild symptoms that last for a few days while the body readjusts.
Expert insight. ...Read more

Dr. Alan Ali
789 Doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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I took wellbutrin (bupropion) for 7yrs. Been off for 4mnths. Can I take it on days that I feel overly anxious? Will it work, or does it have to be in system longer?

I took wellbutrin (bupropion) for 7yrs. Been off for 4mnths. Can I take it on days that I feel overly anxious? Will it work, or does it have to be in system longer?

Get an evaluation: Sounds like you might need another assessment of your symptoms so you can get an accurate diagnosis and treatment. It is not recommended in most cases to take wellbutrin (bupropion) on an as needed basis. ...Read more

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I took wellbutrin for 2days 1xa day 150mg its making worse how long till out of system and can try something else want to try inderal.

I took wellbutrin for 2days 1xa day 150mg its making worse how long till out of system and can try something else want to try inderal.

3-5 days: If you were only taking wellbutrin for 2 days just to be safe I'd wait 3-5 days before starting inderal under your PCP direction naturally, but usually 2 days of a med like wellbutrin would have minimal adverse effects if any stopping it abruptly as you have done.
having said that any med changes should be closely monitored by you primary care provider. ...Read more

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Does wellbutrin (bupropion) have an effect on a woman's reproductive system?

Not directly: Unlike many other antidepressants which can decrease libido and/or sexual performance wellbutrin (bupropion) is more likely to increase interest in sexual activity and in males is less likely to cause impotence. ...Read more

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I'm taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take a vyvanse with these medications in my system?

I'm taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take a vyvanse with these medications in my system?

Caution: You already have significant drug interactions with the 3 meds listed. Adding Vyvanse plus Wellbutrin (bupropion) increases risk for seizures. Vyvanse plus Lexapro increases side effects of Vyvanse and risk for serotonin syndrome. Review these meds with prescribing doctor. You need close medical supervision to take these medications. I hope this helps. ...Read more

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How long should it take to stop taking wellbutrin (bupropion)?

Are you asking: How long you need to take for a specific condition or are you asking how to taper off it. What is the condition being treated? Please clarify and re-ask. Thank you. ...Read more

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Anyone have problems with long term wellbutrin (bupropion) use?

Generally no: Wellbutrin (bupropion) as a long term medication to treat and prevent major depression is generally safe and does not cause any known harm. ...Read more

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How long it takes to feel better when taking wellbutrin (bupropion) xl?

2 weeks: Most psychiatric medication takes about two weeks to start showing any change in individuals. ...Read more

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How long does it take for wellbutrin (bupropion) to have maximum effect?

How long does it take for wellbutrin (bupropion) to have maximum effect?

Depends: It should be fully in your system in 72 hours. However, it may take several weeks to have an impact on your depression. If you have questions, contact your physician. ...Read more

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Please tell me how long it takes for to adjust to wellbutrin (bupropion)?

Variable: Though I have seen some people start feeling better within a few days, 2-3 weeks is a more reasonable expectation. It can take 4-6 weeks to see the full benefit. ...Read more

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How long does it take to lose your appetite when taking Wellbutrin (bupropion)?

How long does it take to lose your appetite when taking Wellbutrin (bupropion)?

It depends: While Wellbutrin (bupropion) is considered a weight neutral antidepressant, losing one's appetite is not necessarily expected. However, you will be less likely to gain weight from it. If your depression has led to a weight gain due to emotional eating, you may find that the urge to eat like that will decrease as the medicine reduces your depression. ...Read more

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I just started on 100mg of wellbutrin (bupropion) for 5 days then up to 300mg. How long before I feel the effects?

Depends...: Most antidepressants take about 2 weeks or so before you notice the therapeutic effects. However you can experience side effects after the 1st dose. ...Read more

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How long does it take to feel the effects of Wellbutrin (bupropion)? I've been on it for 5 weeks and still feeling down.

4-6 Weeks: Bupropion is an antidepressant that works primarily by increasing dopamine.

If you have had absolutely no improvement in your depression, you may be on too low of a dose, or this may just be a medication that doesn't work for you.

Also make sure you have the right diagnosis.

Do NOT discontinue this without consulting your psychiatrist, but I would bring this up with him/her. ...Read more

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If I'm taking wellbutrin (bupropion) 100 mg a day how long will it take me to feel better and like myself? I've taken it before but it was XR kind.

If I'm taking wellbutrin (bupropion) 100 mg a day how long will it take me to feel better and like myself? I've taken it before but it was XR kind.

Wellbutrin (bupropion): Wellbutrin (bupropion) takes 4-6 weeks for effectiveness, but you may get some response before that. Your doctor may also need to gradually adjust your dosage. It may help you feel better -- learning to like yourself is an additional process best helped through psychotherapy. The medication can clear depressive feelings so that working through personal issues does not feel so overwhelming. ...Read more

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Are there long-term effects of wellbutrin (bupropion)?

Are there long-term effects of wellbutrin (bupropion)?

Officially, none: No warnings about long-term use of wellbutrin (bupropion) have been issued. But, you have to realize that its makeup is similar to amphetamine, and is dopamine-enhancing. It can cause jitteriness, twitching, and seizures even in short-term. It can be difficult to wean from, because of irritability and anger -- not unlike nicotine withdrawal for which it is used (as zyban). Ongoing need should be reviewed. ...Read more

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How long after stopping wellbutrin (bupropion) can I drink?

How long after stopping wellbutrin (bupropion) can I drink?

Wellbutrin, (bupropion) Alcohol: Commend yourself if you did not use Alcohol while taking Wellbutrin (bupropion) for Depression.
Did you discuss with your Psychiatrist for gradual withdrawal of Wellbutrin (bupropion), possibly 6 weeks to avoid withdrawal symptoms.
It gets out of system in about 7 days.
See a Psychiatrist if you have history of Alcohol cravings, hangovers, blackouts, anxiety, depression, paranoia and memory problems; Attend AA meetings ...Read more

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I'm changing my medication from Effexor (venlafaxine) 300mgs to wellbutrin 150mgs. How long before I notice a change in my mood?

I'm changing my medication from Effexor (venlafaxine) 300mgs to wellbutrin 150mgs. How long before I notice a change in my mood?

Many Variables: When switching from one antidepressant to another it is difficult to predict how quickly the new medication will take effect. Generally one expects an antidepressant to begin to work after two weeks with the maximum benefit at six weeks. One should taper slowly off Effexor (venlafaxine) due to discontinuation symptoms. These would include anxiety and flu-like aches and pains. Work closely with your md. ...Read more

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Took wellbutrin 2 days and stopped cause I noticed sugar was 126 in am day 2 if this is the cause of elevation... How long to normalize? Not diabetic

See below: It's not advised to stop medication without the knowledge of prescribing provider. Please contact the doctor who prescribed the medication to figure out further steps. Good Luck! ...Read more

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How long on average is the adjustment period is for wellbutrin (bupropion)?

1to 2 weeks: For relief from depression it generally takes weeks for significant relief from symptoms. For concentration problems, the time is much shorter. ...Read more

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How long does it take a prescription medication like wellbutrin (bupropion) to start working?

How long does it take a prescription medication like wellbutrin (bupropion) to start working?

Can be very fast: Within a few days to weeks, but full effect will take many weeks to manifest. Keep in mind also dose adjustment is usually necessary to get to the right dose. Not being at the right dose can mean no effect at all. Don't give up too soon. ...Read more

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I have been on citalopram 40 mg daily for two years. I am now prescribed Wellbutrin (bupropion) 150mg daily as an add on. How long will it take to see improvement?

Ask your provider: Always discuss this sort of thing w/ your provider. When a medication is prescribed - have a list of standard and additional particular questions. This is one to always ask - "How long should I expect to wait to see results? " Others are about what to look for positively and side effects to report. Withdrawal issues, things to avoid, things to do, etc. This makes you a wise consumer! Best wishes! ...Read more

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How long can a person be treated for depression with wellbutrin (bupropion)?

Wellbutrin (bupropion): For first episode of depression, usually 6 months to a year. If recurrent, it takes longer. ...Read more

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My doctor just upped my dosage of wellbutrin (bupropion) from 450mgs per day to 600mgs per day. How long until I notice a change in my mood?

My doctor just upped my dosage of wellbutrin (bupropion) from 450mgs per day to 600mgs per day. How long until I notice a change in my mood?

Depends: It depends how long you've been taking it altogether. When first starting a medication it can take 4-6 weeks for the therapeutic benefits to occur. Changes in dosage once you've already been on it usually don't take quite as long, but can. ...Read more

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I started feeling severely anxious/more depressed after 3 weeks of taking Wellbutrin (bupropion). I stopped taking it 2 days ago. How long until this goes away?

Mood instability: You might wish to talk to your prescriber. While most side effects pass within three-seven days, your reaction may be a little different. In certain situations, these types of meds can trigger mood instability with worsening depression or an anxious/agitated feeling. Also Wellbutrin (bupropion) because of its triple action, can cause sudden worsening of suicidal feelings and some anxiety. ...Read more

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What do you suggest if my doctor just upped my dosage of wellbutrin (bupropion) from 450mgs per day to 600mgs per day. How long will it take before I notice a change in my mood?

Not sure: That's a high dose for that medication. Tough to say when you might notice improvement but if you are having side effects then maybe switch to a different medication. I think its unlikely that going from 450 to 600 will make a huge difference. I think I would have augmented instead of increasing. Do you have insomnia? ...Read more

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I stopped taking my medications over a month ago and have had no relapse, withdrawals, or any symptoms. How long until I can switch medications? I was previously on abilify, (aripiprazole) wellbutrin, and straterra.

I stopped taking my medications over a month ago and have had no relapse, withdrawals, or any symptoms. How long until I can switch medications? I was previously on abilify, (aripiprazole) wellbutrin, and straterra.

It depends: If you stopped taking your medications a month ago, I hope this was a mutual decision between you and your physician. I don't know what conditions you were being treated for, since these medicines could be used in different ways. Conditions do not have to relapse immediately for you to be in danger of that possibility. Your doctor is the best person to answer your question. ...Read more

Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more