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Doctor insights on: How Long Does Wellbutrin Stay In Your System

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I've been off of my wellbutrin (bupropion) for 2 weeks now. Got refill, is it still in my system and how long until I feel better again? (450 mgs)

I've been off of my wellbutrin (bupropion) for 2 weeks now. Got refill, is it still in my system and how long until I feel better again? (450 mgs)

2-3 days to 8wks: Although most symptoms subside within a few days, some may continue for 8 weeks or more and require medical attention. Early intervention greatly improves treatment and control of symptoms due to withdrawal. With proper medical advice, discontinuing wellbutrin (bupropion) is safe. Most people experience mild symptoms that last for a few days while the body readjusts. Expert insight.

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Dr. Alan Ali
783 Doctors shared insights

Bupropion (Definition)

Also called wellbutrin (bupropion) or zyban or aplenzin, is an atypical antidepressant & smoking cessation aid, which has mild psychostimulant action. It is a norepinephrine/dopamine reuptake inhibitor. It can lower seizure threshold at high doses, ...Read more


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I took wellbutrin (bupropion) for 7yrs. Been off for 4mnths. Can I take it on days that I feel overly anxious? Will it work, or does it have to be in system longer?

I took wellbutrin (bupropion) for 7yrs. Been off for 4mnths. Can I take it on days that I feel overly anxious? Will it work, or does it have to be in system longer?

Get an evaluation: Sounds like you might need another assessment of your symptoms so you can get an accurate diagnosis and treatment. It is not recommended in most cases to take wellbutrin (bupropion) on an as needed basis.

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I took wellbutrin for 2days 1xa day 150mg its making worse how long till out of system and can try something else want to try inderal.

I took wellbutrin for 2days 1xa day 150mg its making worse how long till out of system and can try something else want to try inderal.

3-5 days: If you were only taking wellbutrin for 2 days just to be safe I'd wait 3-5 days before starting inderal under your PCP direction naturally, but usually 2 days of a med like wellbutrin would have minimal adverse effects if any stopping it abruptly as you have done. Having said that any med changes should be closely monitored by you primary care provider.

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Does wellbutrin (bupropion) have an effect on a woman's reproductive system?

Not directly: Unlike many other antidepressants which can decrease libido and/or sexual performance wellbutrin (bupropion) is more likely to increase interest in sexual activity and in males is less likely to cause impotence.

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I'm taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take a vyvanse with these medications in my system?

I'm taking lexapro Wellbutrin (bupropion) and alprazolam. Is it safe to take a vyvanse with these medications in my system?

Caution: You already have significant drug interactions with the 3 meds listed. Adding Vyvanse plus Wellbutrin (bupropion) increases risk for seizures. Vyvanse plus Lexapro increases side effects of Vyvanse and risk for serotonin syndrome. Review these meds with prescribing doctor. You need close medical supervision to take these medications. I hope this helps.

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How long should it take to stop taking wellbutrin (bupropion)?

Are you asking: How long you need to take for a specific condition or are you asking how to taper off it. What is the condition being treated? Please clarify and re-ask. Thank you.

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Anyone have problems with long term wellbutrin (bupropion) use?

Generally no: Wellbutrin (bupropion) as a long term medication to treat and prevent major depression is generally safe and does not cause any known harm.

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How long it takes to feel better when taking wellbutrin (bupropion) xl?

2 weeks: Most psychiatric medication takes about two weeks to start showing any change in individuals.

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How long does it take for wellbutrin (bupropion) to have maximum effect?

How long does it take for wellbutrin (bupropion) to have maximum effect?

Depends: It should be fully in your system in 72 hours. However, it may take several weeks to have an impact on your depression. If you have questions, contact your physician.

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Please tell me how long it takes for to adjust to wellbutrin (bupropion)?

Variable: Though I have seen some people start feeling better within a few days, 2-3 weeks is a more reasonable expectation. It can take 4-6 weeks to see the full benefit.

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How long does it take to lose your appetite when taking Wellbutrin (bupropion)?

How long does it take to lose your appetite when taking Wellbutrin (bupropion)?

It depends: While Wellbutrin (bupropion) is considered a weight neutral antidepressant, losing one's appetite is not necessarily expected. However, you will be less likely to gain weight from it. If your depression has led to a weight gain due to emotional eating, you may find that the urge to eat like that will decrease as the medicine reduces your depression.

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I just started on 100mg of wellbutrin (bupropion) for 5 days then up to 300mg. How long before I feel the effects?

Depends...: Most antidepressants take about 2 weeks or so before you notice the therapeutic effects. However you can experience side effects after the 1st dose.

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How long does it take to feel the effects of Wellbutrin (bupropion)? I've been on it for 5 weeks and still feeling down.

4-6 Weeks: Bupropion is an antidepressant that works primarily by increasing dopamine. If you have had absolutely no improvement in your depression, you may be on too low of a dose, or this may just be a medication that doesn't work for you. Also make sure you have the right diagnosis. Do NOT discontinue this without consulting your psychiatrist, but I would bring this up with him/her.

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If I'm taking wellbutrin (bupropion) 100 mg a day how long will it take me to feel better and like myself? I've taken it before but it was XR kind.

If I'm taking wellbutrin (bupropion) 100 mg a day how long will it take me to feel better and like myself? I've taken it before but it was XR kind.

Wellbutrin (bupropion): Wellbutrin (bupropion) takes 4-6 weeks for effectiveness, but you may get some response before that. Your doctor may also need to gradually adjust your dosage. It may help you feel better -- learning to like yourself is an additional process best helped through psychotherapy. The medication can clear depressive feelings so that working through personal issues does not feel so overwhelming.

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Are there long-term effects of wellbutrin (bupropion)?

Are there long-term effects of wellbutrin (bupropion)?

Officially, none: No warnings about long-term use of wellbutrin (bupropion) have been issued. But, you have to realize that its makeup is similar to amphetamine, and is dopamine-enhancing. It can cause jitteriness, twitching, and seizures even in short-term. It can be difficult to wean from, because of irritability and anger -- not unlike nicotine withdrawal for which it is used (as zyban). Ongoing need should be reviewed.

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How long after stopping wellbutrin (bupropion) can I drink?

How long after stopping wellbutrin (bupropion) can I drink?

Wellbutrin, (bupropion) Alcohol: Commend yourself if you did not use Alcohol while taking Wellbutrin (bupropion) for Depression. Did you discuss with your Psychiatrist for gradual withdrawal of Wellbutrin (bupropion), possibly 6 weeks to avoid withdrawal symptoms. It gets out of system in about 7 days. See a Psychiatrist if you have history of Alcohol cravings, hangovers, blackouts, anxiety, depression, paranoia and memory problems; Attend AA meetings

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I'm changing my medication from Effexor (venlafaxine) 300mgs to wellbutrin 150mgs. How long before I notice a change in my mood?

I'm changing my medication from Effexor (venlafaxine) 300mgs to wellbutrin 150mgs. How long before I notice a change in my mood?

Many Variables: When switching from one antidepressant to another it is difficult to predict how quickly the new medication will take effect. Generally one expects an antidepressant to begin to work after two weeks with the maximum benefit at six weeks. One should taper slowly off Effexor (venlafaxine) due to discontinuation symptoms. These would include anxiety and flu-like aches and pains. Work closely with your md.

Wellbutrin (Definition)

Bupropion is an addiction reducing agent and an antidepressant which are both a ...Read more