Doctor insights on:
How Long Does Loratadine Stay In Your System
One day: Claritin (loratadine) 10 mg pill is dosed once daily. That's because it's effect will last about 24 hours, after that it's antihistamine effect wanes. However, Claritin is metabolized by the liver into another active compound called desloratadine, so the antihistamine effect can last a while. This is why most allergists have patients stop their Claritin a number of days before skin testing them. ...Read more
3-5 days: The average half-life of Claritin (loratadine) is 8 hours meaning that half the dose is gone/metabolized after 8 hours and after 8 more hours another half is gone. Doing the math, the Claritin (loratadine) is effectively out of a person's system in 3-5 days, except in geriatric patients it could possibly take up to 10 days. ...Read more
My 6mo old was prescribed loratadine/ambroxol. She seems very drowsy, why? And how long will it stay I her system?
Mgt: If your baby is more drowsy/lethargic, not feeding well, please see your ED. This may not be related to the medications, but rather to an illness. The ambroxol should be discontinued until further evaluation is completed. For excessive mucus production, nasal saline drops and gentle suction is the only treatment advised in this age group, unless there is a tracheostomy or some other problem. ...Read more
If I take zertec for a long period 10mo then switch to Claritin (loratadine) can my sinuses become dependent on zyrtec and over produce mucus w/o zyrtec in system?
Unlikely: While the "good" effect of zyrtec (cetirizine) will be gone in several days, there is no known problem of "rebound" or worsening symptoms when stopping oral antihistamines. More likely, is the continued exposure to the allergens. Here is where an allergist will be able to assist. ...Read more
Quickest way: Quickest way is to wait 24 hours and let it clear out on its own. ...Read more
I had 30 mg of Zyrtec on Monday, 40 mg of Claritin (loratadine) on Tuesday, and 30 mg of Claritin (loratadine) on Wednesday. When will it all be out of my system?
Med clearance: 50 - 60 percent clearance in 24-30 hours, then total clearance in 5-7 days ...Read more
How much allegra is safe on a daily basis? My system needs a break from claritin (loratadine) and zyrtec apparently, but 1 allegra is not working fully.
If I stop taking Claritin (loratadine) will the side effects go away overnight and by that I mean in a 24 hour period? Or will it take a couple of days for all the medicine to be out of my system?
Up to 1 hour: Claritin (loratadine) can work relatively quickly in most people. That is, it usually works within 30 minutes. However, in some people it may take up to 60 minutes to have its full effect. If it is not working within that time, or if the duration of effect becomes less and less, seeing an allergy specialist for allergy testing would be recommended as other treatments may be more effective. ...Read more
Pretty Quickly: Most antihistamines will start to work within the first 30-40 minutes. ...Read more
What are the differences between loratadine and desloratidine in how well it works or how long it lasts?
Take one, get both: When you take loratidine, your liver breaks it down to desloratine which is actually responsible for the anti-histamine effects you need. Desloratidine has a much longer effect (28 hours) than loratidine (8 hours) which is why loratidine lasts such a long time. ...Read more
Prob ok: Antihistamines have been around for decades, and certainly many more potent than loratadine. They say worldwide the most common drug taken is diphenhydramine, mostly for the sedative properties (as a sleep aid). Antihistamines can affect certain types of glaucoma, and accentuate urine retention in those with prostate issues and dry mucous membranes, but usually not so much with loratadine per say. ...Read more
3 days to reach peak: Claritin (loratadine) (loratidine) takes 3 days to reach a steady state, so it could take that long for it to work on hives. Other non-drowsy antihistamines are a better choice: Allegra (fexofenadine) reaches peak effect within 2 hours and Zyrtec (cetirizine) reaches peak effect in 1-2 hours. If you see no benefit at all within 5 hours of taking these, they probably will not work for you. ...Read more
How many weeks does it take for claritin (loratadine) 10mg to work? How long should I give it a try before deciding to switch to a different antihistamine?
Try for a few days: Antihistamines begin to work in less than an hour but a person may not feel significant relief for a few days. Claritin tends to be one of the weaker non-drowsy antihistamines. Others available without a prescription are Zyrtec, Allegra and Xyzal. If antihistamines are still not working then an evaluation by an allergist can be helpful to determine the cause of symptoms ...Read more
Headache is getting worse. I have been on claritin, (loratadine) flonaz, and zyrtec but nothing seems to help long-term. Any suggestions?
Evaluation: I would recommend that you confirm with your provider if allergies are the reason for your headache. You have used allergy medications to treat your headache and apparently have not had benefit. I think it may be likely that your headache is not allergy related at this point. ...Read more
After taking 2 days of Claritin (loratadine) d 24 hour then stopping how long can I expect the side effect to last. It stimulated my anxiety.
About 24 hours: Decongestants like the 'D' in this version of Claritin (loratadine) can have side effects like restlessness, increased heart rate and blood pressure. It's an extended release formula which helps it last 24 hrs. After that 24hrs, the last bit of the D to be released should be pretty much out of your system within another 24hrs. If having prolonged or worrisome symptoms, seek medical care. ...Read more
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