Doctor insights on:
How Long Does Dopamine Withdrawal Last
Could abilify (aripiprazole) trigger voices or trigger voices upon its withdrawal because it also raises dopamine levels? I think I experienced this when taking it
Will the number of dopamine receptors from antipsychotic usage and its withdrawal lower over time? I think all this extra dopamine is giving insomnia
Down regulation: In theory, the use of any receptor-driven chemical stimulus over time will result in reduction, or down-regulation of those receptors, especially if the dose is increased. ...Read more
Do antipsychotics up regulate or down regulate dopamine receptors? I heard withdrawal can cause super sensitivity psychosis. Do the receptors lower?
Antipsychotic meds: There are different "generations" of antipsychotic medications. Many antipsychotic medications have antagonistic effects at a specific receptors, such as the D1, D2, D3 receptors. Even 5HT1a specific receptors related to Serotonin can be effected. It is important to know that different antipsychotic medications can have different effects on difference receptors. More specific info is needed. ...Read more
My friend take risperidone after methamphetamine withdrawal by psych, any other antipsychotic not cause appetite inc? Not dopamine antagonist. Regards
I'm very sensitive to all meds, on cabergoline for elevated prolactin, in range now, im afraid I will have withdrawl from dopamine increase.?
As above: Best thing to discuss with u prescriber. ...Read more
Are there any Drs. Here that have significant experience with Dopamine Agonist Withdrawl Syndrome? I like my P doc, but I'm his first cause of DAWS
L-dopa levels: L-dopa comes in short and long acting forms, which last from two to about eight hours. After starting l-dopa therapy, if the doses are taken very regularly, the brain levels will stabilize after four to six weeks, because of the many interacting brain regions that are affected.. ...Read more
How long does Levodopa take to work with Dopamine-responsive dystonia? What's the usual dose for this?
Depends: There is a titration period where your body equilibrates with the new medicine which depends on the dose titration and goal dosage. If you're at those goals then you should be able to tell whether it's helping as Levodopa only lasts around 12 hours in your body ...Read more
Can being on antipsychotics long term lower dopamine in the D2 receptors but raise dopamine in unblocked dopamine receptors due to extra receptors?
Yes: Yes, they can, depending on the type of antipsychotic. ...Read more
1-6 months: Some people recover fairly quickly (as soon as 2 weeks). Some take longer, up to 6 months. It depends on the medication taken, the dose and how long it was taken. ...Read more
If we only knew,: That is one of the most important questions in addiction medicine--how long until I feel good again? I think that if we knew the answer to this question for everyone, drug addiction would be much easier to treat-- simply because you would know exactly how long you will feel withdraw. It's the not-knowing that makes it so hard b/c you don't know when the end is. Makes it much harder! ...Read more
After taking drugs like ecstasy 2 pills per month. How long does it take for your serotonin and dopamine to come back to normal?
Impossible to say: MDMA has shown some evidence of permanent damage to the dopamine system. It can take months to a year for temporary drug damage to heal in the brain. Also, multible drugs besides MDMA are currently being sold as ecstasy because of the high demand for MDMA, So impossible to more accurately answer your question. ...Read more
What are the effects of prolonged anxiety and anger on acetylcholine, serotonin, dopamine levels?
Negative emotions: Strongly impact our biochemistry in general. They can eventually burn out our adrenal glands. For a lab analysis of neurotransmitters via urine your doc can use neuroscience lab, who specialize in this, along with supplemental formulas to balance things naurally. Peace and good health. ...Read more
Can too much dopamine after exercise lead to psychosis? Can too much dopamine leave one up all night long.
Not likely to either: However what is too much in both questions? ...Read more
Does geodon (ziprasidone) and risperdal continue to blockade dopamine after the meds ate long for out of your system?
I can no longer orgasm. How do I get it back? I believe I lost it to frequent masturbation. Will reducing prolactin or increasing dopamine level work
Many factors: Many factors can lead to sexual dysfunction. While hormonal balance or med side effects can, state of mind can be another; sometimes, anxiety about it can make it worse. Abstaining from sexual activity should bring back libido more effectively than changing hormone/neurotransmitter balance. Anxiety management also. If med side effects, then med changes may be needed. ...Read more
What does it mean if my dopamine went down upon standing? Last time it went up 12 to 18 this time 12 and down to 10? Any meaning behind this? It was accatacholomine blood test at, mayo clinic.
Doesn't make sense: I don't think you dopine level would drop with change of position. There should be another explanation. Should discuss more with the doctor. I don't have your history ...Read more
Is Selegeline bad for liver, Is there any problem for long term therapy? Will it work on my Dopamine-repondsive distonia. Can I combine it with Baclofen
Interesting question. The simple answer to your first question is that selegiline is relatively safe for the liver, unless there is pre-existing liver disease. The main risk of selegiline is heart disease for patients with a history of heart attacks or those who use other medicines that affect the heart.
Considering the other medicines you use, selegiline should be safe. ...Read more
Is it possible or probable that the drug Adderall, (dextroamphetamine and racemic amphetamine) if used long-term, could cause eventual dopamine depletion?
I have read reports that long term Adderall (dextroamphetamine and racemic amphetamine) abuse can cause permanent dopamine damage. Would taking 30mg Adderall (dextroamphetamine and racemic amphetamine) a few times a month do same thing?
No: Regular therapeutic dose use is not the same abuse. ...Read more
If you take ADHD stimulants for eds or sleep disorders will they deplete dopamine (or other vital transmitters?) what are the long term consequences?
Probably not: Used under medical supervision, stimulants can be used for long periods without known adverse fx. However, stimulants not first choice for sleep disorders, inclu some with short duration and the risk would be eds at the wrong time, eg driving. You need a careful expplanation of the sleep disorder and the rationale for stimulants instead of other alertness promoting agents. ...Read more
5HTP/L-dopa: Only if prescribed. Should be ok.Get a more detailed answer ›
Does dopa mucuna and l dopa cause people to loss weight because they are getting dopamine back that was blocked by antipsychotics?
WAY oversimplifying: Weight gain with antipsychotics is poorly understood but probably has nothing to do with dopamine. May be 1 or more other receptor types, including histaminic H1, serotonin 2A & 2C, muscarinic M (3), & adrenergic receptors. (Quiz later.) Receptor neurochemistry is INCREDIBLY complex & subtle & messing around out of ignorance with stuff like mucuna after stopping antipsychotics could be risky. ...Read more
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