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Doctor insights on: How Long Does Dopamine Withdrawal Last

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Dr. Martin Johnson
905 Doctors shared insights

Dopamine (Definition)

Dopamine is an inotrope which is a kind of heart ...Read more


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Can zyprexa and antipsychotics withdrawal lead to an excess of dopamine? Will these dopamine levels go back down eventually?

Almost always: Yes, your dopamine will definitely be affected by the addition or withdrawal of such medications. However, from what we know dopamine levels will go back down to normal shortly. ...Read more

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Will the number of dopamine receptors from antipsychotic usage and its withdrawal lower over time? I think all this extra dopamine is giving insomnia

Will the number of dopamine receptors from antipsychotic usage and its withdrawal lower over time? I think all this extra dopamine is giving insomnia

Down regulation: In theory, the use of any receptor-driven chemical stimulus over time will result in reduction, or down-regulation of those receptors, especially if the dose is increased. ...Read more

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Do antipsychotics up regulate or down regulate dopamine receptors? I heard withdrawal can cause super sensitivity psychosis. Do the receptors lower?

Do antipsychotics up regulate or down regulate dopamine receptors? I heard withdrawal can cause super sensitivity psychosis. Do the receptors lower?

Antipsychotic meds: There are different "generations" of antipsychotic medications. Many antipsychotic medications have antagonistic effects at a specific receptors, such as the D1, D2, D3 receptors. Even 5HT1a specific receptors related to Serotonin can be effected. It is important to know that different antipsychotic medications can have different effects on difference receptors. More specific info is needed. ...Read more

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Are there any Drs. Here that have significant experience with Dopamine Agonist Withdrawl Syndrome? I like my P doc, but I'm his first cause of DAWS

Neurologists: Neurologists often have experience with this disorder. It is often helpful to use a small amount of levodopa/carbidopa to protect against the withdrawal for 1-2 weeks, like 100/25 mg three times a day. Hope that helps! ...Read more

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, how long will it take for my dopamine levels to become stable on l dopa?

, how long will it take for my dopamine levels to become stable on l dopa?

L-dopa levels: L-dopa comes in short and long acting forms, which last from two to about eight hours. After starting l-dopa therapy, if the doses are taken very regularly, the brain levels will stabilize after four to six weeks, because of the many interacting brain regions that are affected.. ...Read more

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How long does it take for dopamine to return?

How long does it take for dopamine to return?

Always present: Dopamine is a neurotransmitter found in the brain. It is never not present. Its level of activity and volume may be changed by medicines and disease processes. ...Read more

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How long does Levodopa take to work with Dopamine-responsive dystonia? What's the usual dose for this?

How long does Levodopa take to work with Dopamine-responsive dystonia? What's the usual dose for this?

Depends: There is a titration period where your body equilibrates with the new medicine which depends on the dose titration and goal dosage. If you're at those goals then you should be able to tell whether it's helping as Levodopa only lasts around 12 hours in your body ...Read more

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How long do dopamine levels stay abnormal after opiate use?

How long do dopamine levels stay abnormal after opiate use?

1-6 months: Some people recover fairly quickly (as soon as 2 weeks). Some take longer, up to 6 months. It depends on the medication taken, the dose and how long it was taken. ...Read more

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How long do dopamine levels return to normal after stopping opiate use?

How long do dopamine levels return to normal after stopping opiate use?

If we only knew,: That is one of the most important questions in addiction medicine--how long until I feel good again? I think that if we knew the answer to this question for everyone, drug addiction would be much easier to treat-- simply because you would know exactly how long you will feel withdraw. It's the not-knowing that makes it so hard b/c you don't know when the end is. Makes it much harder! ...Read more

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What are the effects of prolonged anxiety and anger on acetylcholine, serotonin, dopamine levels?

What are the effects of prolonged anxiety and anger on acetylcholine, serotonin, dopamine levels?

Negative emotions: Strongly impact our biochemistry in general. They can eventually burn out our adrenal glands. For a lab analysis of neurotransmitters via urine your doc can use neuroscience lab, who specialize in this, along with supplemental formulas to balance things naurally. Peace and good health. ...Read more

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I can no longer orgasm. How do I get it back? I believe I lost it to frequent masturbation. Will reducing prolactin or increasing dopamine level work

I can no longer orgasm. How do I get it back? I believe I lost it to frequent masturbation. Will reducing prolactin or increasing dopamine level work

Many factors: Many factors can lead to sexual dysfunction. While hormonal balance or med side effects can, state of mind can be another; sometimes, anxiety about it can make it worse. Abstaining from sexual activity should bring back libido more effectively than changing hormone/neurotransmitter balance. Anxiety management also. If med side effects, then med changes may be needed. ...Read more

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What does it mean if my dopamine went down upon standing? Last time it went up 12 to 18 this time 12 and down to 10? Any meaning behind this? It was accatacholomine blood test at, mayo clinic.

What does it mean if my dopamine went down upon standing? Last time it went up 12 to 18 this time 12 and down to 10? Any meaning behind this? It was accatacholomine blood test at, mayo clinic.

Doesn't make sense: I don't think you dopine level would drop with change of position. There should be another explanation. Should discuss more with the doctor. I don't have your history ...Read more

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Is Selegeline bad for liver, Is there any problem for long term therapy? Will it work on my Dopamine-repondsive distonia. Can I combine it with Baclofen

Is Selegeline bad for liver, Is there any problem for long term therapy? Will it work on my Dopamine-repondsive distonia. Can I combine it with Baclofen

Selegilene: Interesting question. The simple answer to your first question is that selegiline is relatively safe for the liver, unless there is pre-existing liver disease. The main risk of selegiline is heart disease for patients with a history of heart attacks or those who use other medicines that affect the heart.

Considering the other medicines you use, selegiline should be safe. ...Read more

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Is it possible or probable that the drug Adderall, (dextroamphetamine and racemic amphetamine) if used long-term, could cause eventual dopamine depletion?

Is it possible or probable that the drug Adderall, (dextroamphetamine and racemic amphetamine) if used long-term, could cause eventual dopamine depletion?

No evidence: Amphetamines have been used therapeuticly for over 90 years. There is no evidence of depletion of dopamine brain stores from the therapeutic use. ...Read more

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If you take ADHD stimulants for eds or sleep disorders will they deplete dopamine (or other vital transmitters?) what are the long term consequences?

If you take ADHD stimulants for eds or sleep disorders will they deplete dopamine (or other vital transmitters?) what are the long term consequences?

Probably not: Used under medical supervision, stimulants can be used for long periods without known adverse fx. However, stimulants not first choice for sleep disorders, inclu some with short duration and the risk would be eds at the wrong time, eg driving. You need a careful expplanation of the sleep disorder and the rationale for stimulants instead of other alertness promoting agents. ...Read more

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Some docs on here said l-tyro can help w dopamine depletion from stims. Is this with stims or on off days from them? Daily? Would this b 2stimulating?

Follow the: Recommended dose on the label. Feel for yourself the effect. If it's too stimulating then decrease the dose. Tyrosine indeed increase the level of neurotransmitters like Dopamine and norepinephrine. ...Read more

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Does dopa mucuna and l dopa cause people to loss weight because they are getting dopamine back that was blocked by antipsychotics?

Does dopa mucuna and l dopa cause people to loss weight because they are getting dopamine back that was blocked by antipsychotics?

WAY oversimplifying: Weight gain with antipsychotics is poorly understood but probably has nothing to do with dopamine. May be 1 or more other receptor types, including histaminic H1, serotonin 2A & 2C, muscarinic M (3), & adrenergic receptors. (Quiz later.) Receptor neurochemistry is INCREDIBLY complex & subtle & messing around out of ignorance with stuff like mucuna after stopping antipsychotics could be risky. ...Read more

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What OTC pills raise dopamine?

What OTC pills raise dopamine?

Careful: You have to be careful with OTC meds in general, increasing dopamine may be associated with increased risk of psychosis. OTC and "natural " drugs that do so are not heavily researched, so one needs to be careful ...Read more

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What medicines increase dopamine level?

What medicines increase dopamine level?

Parkinson's example: L-DOPA is the classic drug to enhance dopamine function, but dopamine agonists such a ropinorole, or pramipexole can mimic effect. And we have a number of agents to prolong the dopamine effects, such as entacapone or Azilect (rasagiline). ...Read more

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How can I replace dopamine in my system?

Please clarify: Your post is not clear. Please repost your question with an explanation of how and why you consider your "system" to be lacking in dopamine and to need replacement of it. ...Read more