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Doctor insights on: How Long Does A Hereditary Angioedema Attack Typically Last

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How long does a hereditary angioedema attack typically last?

How long does a hereditary angioedema attack typically last?

Can vary: Attack duration varies from person to person but typically lasts 3-5 days. ...Read more

Dr. Douglas Johnston
130 doctors shared insights

Angioedema (Definition)

A condition in which swelling occurs under the skin. Angioedema is due to fluid leaking from blood vessels usually due to an ...Read more


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At what age do attacks of hereditary angioedema start?

Most before puberty: 40% of individuals with hereditary angioedema (hae) have attacks before age 5 and 75% have attacks before age 15. Swelling is not itchy and there are no hives in hae. Frequency of attacks increases after puberty. Diagnosis usually made in 2nd or 3rd decade of life by history with confirmatory blood tests. See your md for diagnosis and if indicated preventive treatment. ...Read more

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When would you consider hereditary angioedema attacks serious?

When would you consider hereditary angioedema attacks serious?

Close the airway: Hereditary angioedema is characterized by episodes of tissue swelling in the face, throat, limbs, and abdomen. In most cases, the swelling develops over hours but sometimes it may take only minutes. The most serious attacks swell the throat closed which can quickly cause respiratory arrest & death if not treated. Frequent & unpredictable attacks are also serious and require preventative treatment. ...Read more

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What's hereditary angioedema?

Genetic disorder: HAE is genetic disorder resulting in unpredictable swelling of any part of the body. It is not caused by histamine, but a chemical caused bradykinin. When released in uncontrolled manner the part of the body where this occurs swells. Swelling occurs within 6-36 hours and if untreated resolves in 2-5 days. There is now a replacement enzyme for Type I and II. 4 on demand meds are FDA approved. ...Read more

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What cause hereditary angioedema?

HAE: Hereditary angioedema (hae) is caused by a uncontrolled activation of a complex cascade of proteins called complement. Hae is a result of a deficiency or lack of functional c1 esterase inhibitor protein. Some patients are born with this problem while other may acquire a lack of c1 esterase inhibitor from an underlying disease such as cancer. There are new treatments available. ...Read more

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Can anyone have hereditary angioedema?

Can anyone have hereditary angioedema?

Yes: Hereditary angioedema types 1 and 2 have a very strong genetic component and typically runs in families. However, spontaneous mutations can occur and hae i and ii can occur on anyone. ...Read more

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What causes hereditary angioedema to occur?

What causes hereditary angioedema to occur?

Abnl or absent prote: Hae is the result of missing or a poorly functioning protein called c1 esterase inhibitor. When this protein is missing or abnormal then a patient may too prone to swelling problems which can be life threatening. ...Read more

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Anyone here treat hereditary angioedema(hae)?

Anyone here treat hereditary angioedema(hae)?

allergists can help: There been exciting and new pharmaceutical options developed for the treatment of acute attacks of hereditary angioedema. Typically, board certified allergists are well-versed in the diagnosis and management of hereditary angioedema. ...Read more

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Does anyone have experience with hereditary angioedema?

Does anyone have experience with hereditary angioedema?

Hereditary angio ede: Hereditary angioedema (ha) is a disease that is typically noted to run in families. It is causes by low levels or poor function in a controller protein called c-1 esterase inhibitor. If swelling (angioedema) occurs with hives, then the angio edema is unlikely to be due to this rare problem. Typical angioedema develops quickly, often maximally within one hour. Ha may swell slowly over many hrs. ...Read more

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Is hereditary angioedema different from regular angioedema?

Is hereditary angioedema different from regular angioedema?

Allergy or not: Angioedema such as swelling of the tongue or lips can occur as the result of an allergy to food or medication. It is usually associated with hives (urticaria). The presence of hives essentially rules out the allergic cause making hereditary or acquired c-1 inhibitor deficiency likely. However, the lack of hives does not rule out allergy. See an allergist for further evaluation either way! ...Read more

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Hereditary angioedema — can anybody tell me anything about?

Abnl or absent prote: Hae is the result of missing or a poorly functioning protein called c1 esterase inhibitor. When this protein is missing or abnormal then a patient may too prone to swelling problems which can be life threatening. ...Read more

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When does prophylaxis for hereditary angioedema become necessary?

It depends: Great question. It really depends on two factors: 1. The severity of the reactions, and 2. The frequency of the reactions. When the reactions become too severe and/or too frequent, prophylactic treatment is recommended. Now, what does too severe/frequent mean? It depends on the person. Ultimately, when the reactions impact a patient's daily life, it's time to consider prophylaxis. ...Read more

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Is hereditary angioedema type III a genetic mutation?

Is hereditary angioedema type III a genetic mutation?

The big unknown: This is a big unknown question, some people have a mutation that can cause type iii and others have an unkown kind that response to treatments of hae. ...Read more

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I was tested for suspected Hereditary Angioedema. The results came back showing my C1-INH function 58% and antigen 59% (range 70-130). What does mean?

Probably: The findings are compatible with HAE especially in the presence of a low C4 level and compatible features of HAE. Many effective treatments are available and I think the next step is for you to consult an allergist for options in treating this potentially life-threatening condition. ...Read more

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C-1 inh is <40% of the expected norm but C4 level normal, wats this mean? Does this mean hav hereditary angioedema? Hx of swelling tongue, nose, lips, vomit

C-1 inh is <40% of the expected norm but C4 level normal, wats this mean? Does this mean hav hereditary angioedema? Hx of swelling tongue, nose, lips, vomit

Can't rule out: A normal C4 would be unusual for hae. You don't mention whether c1 inh level was functional activity or level of protein. Functional (activity) complement tests are extremely dependent on the way the specimen is handled. Both tests should probably be repeated. To sort things out, you should see a board-certified allergist immunologist. ...Read more

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How long can a chronic urticaria last? Apparentely it is related with hashimoto thyroiditis. Any idea? It's been 1year of hives and angioedemas.

How long can a chronic urticaria last? Apparentely it is related with hashimoto thyroiditis. Any idea? It's been 1year of hives and angioedemas.

Can be a long time: The association with hashimoto's thyroiditis is generally just thought to be that people who make antibodies to one thing inappropriately (thyroid) are more likely to make antibodies to other things inappropriately (mast cell receptors which can be a cause for urticaria). Most chronic urticarias last 2 weeks to 2 months, but 10-20% can last more than 2 years. ...Read more

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What other possible DX would there be if I've been told I don't fit hereditary or allergic angioedema profiles?

Need more info: With clinical presentation, one would be unlikely to have both hereditary and allergic angioedema in the same differential. The hallmark of one is lack of pruritis, and the other is pruritis. ...Read more