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Doctor insights on: How Long Do Wilson Disease Patients Live

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Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Minor mystery: We do know that the liver tends to underproduce ceruloplasmin in Wilson's, but this is only the case in about 2/3 of patients and it is famously unreliable as a way of screening. The exact mechanisms still haven't been sorted out. ...Read more

Dr. Robert Hutchman
76 doctors shared insights

Wilson's Disease (Definition)

Wilson disease is a genetic condition in which a person's body cannot handle the normal amount of copper obtained through foods. Over time, the copper accumulates in the body and damages the ...Read more


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Can a carrier (heterozygote) of the wilson disease gene donate part of his/her liver tissue for a living related donor transplant to a patient?

Can a carrier (heterozygote) of the wilson disease gene donate part of his/her liver tissue for a living related donor transplant to a patient?

Yes: Wilsons disease is a disease of copper storage. It is genetically linked. Generally speaking people who are heterozygous (are only carriers) can donate their part of thier livers. People who are heterozygous are carriers and don't have wilson's disease themselves. ...Read more

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How can I treat wilson disease?

How can I treat wilson disease?

Don't self-treat: Usually an oral medicine to manage copper is all that's required. Be very wary of "alternative and complementary" remedies in this very serious illness, and discuss anything you may be using with your gastroenterologist. I'm going to assume you have real Wilson's and not the "pop" Wilson syndrome, which is not a real illness. Best wishes. ...Read more

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How did wilson disease get its name?

How did wilson disease get its name?

Sam Wilson MD: 1878–1937, first described it and named it hepatolenticular degeneration. Perhaps the most treacherous diagnosis in general medicine, and unfortunately is still missed, which is bad because it's quite easy to manage and horrible if missed. There is also a bogus "wilson's disease" -- lay people are invited to self-diagnose as having subtle thyroid disease; no scientific basis. ...Read more

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What is wilson disease? What is the problem in the body?

What is wilson disease?  What is the problem in the body?

Mutated ATP7B: The cells can't transport copper out of their cytoplasm as they should. This cases the complications of liver cell death and cirrhosis, brain damage, and so forth. ...Read more

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Do people with wilson disease have a lot of pain?

Do people with wilson disease have a lot of pain?

No: Movement disorder--deterioration of cognition--hepatitis---joint pain is not very significant--but they get a variety of symptom--ask your doctor. ...Read more

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Can you provide an overview of how wilson disease affects the liver? 

Can you provide an overview of how wilson disease affects the liver? 

See below: Excessive deposition of copper in various tissue including liver, brain and eyes results in tissue damage. See this site for more info. http://www.mayoclinic.com/health/wilsons-disease/ds00411. ...Read more

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Describe the treatments enzyme substitution in wilson disease?

Describe the treatments enzyme substitution in wilson disease?

Wilson disease: Excess opper accumulation with serious end organ damage. Treatment after diagnosis is chelation therapy to diseaseexcess copper. Then avoidance of reaccumulation. See mayo clini wilsons disease well written and presented for non medical personnel. ...Read more

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Hi. What is wilson disease diseas?

Hi. What is wilson disease diseas?

Copper: Wilson's disease is a disorder of copper metabolism causing too much copper in the blood and tissues. ...Read more

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