Top
20
Doctor insights on: How Long Do Wilson Disease Patients Live

Share
1

1
Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Why do wilson disease patient have a low ceruloplasmin level? Is it due to wilson disease itself or low production by liver?

Minor mystery: We do know that the liver tends to underproduce ceruloplasmin in Wilson's, but this is only the case in about 2/3 of patients and it is famously unreliable as a way of screening. The exact mechanisms still haven't been sorted out. ...Read more

Dr. Robert Hutchman
84 doctors shared insights

Wilson's Disease (Definition)

Wilson's disease is a genetic disorder which causes copper to accumulates in body tissues & may cause psychiatric or neurological ...Read more


3

3
Can a carrier (heterozygote) of the wilson disease gene donate part of his/her liver tissue for a living related donor transplant to a patient?

Can a carrier (heterozygote) of the wilson disease gene donate part of his/her liver tissue for a living related donor transplant to a patient?

Yes: Wilsons disease is a disease of copper storage. It is genetically linked. Generally speaking people who are heterozygous (are only carriers) can donate their part of thier livers. People who are heterozygous are carriers and don't have wilson's disease themselves. ...Read more

See 1 more doctor answer
4

4
How can I treat wilson disease?

How can I treat wilson disease?

Don't self-treat: Usually an oral medicine to manage copper is all that's required. Be very wary of "alternative and complementary" remedies in this very serious illness, and discuss anything you may be using with your gastroenterologist. I'm going to assume you have real Wilson's and not the "pop" Wilson syndrome, which is not a real illness. Best wishes. ...Read more

See 1 more doctor answer
5

5
How did wilson disease get its name?

How did wilson disease get its name?

Sam Wilson MD: 1878–1937, first described it and named it hepatolenticular degeneration. Perhaps the most treacherous diagnosis in general medicine, and unfortunately is still missed, which is bad because it's quite easy to manage and horrible if missed. There is also a bogus "wilson's disease" -- lay people are invited to self-diagnose as having subtle thyroid disease; no scientific basis. ...Read more

See 1 more doctor answer
6

6
What is wilson disease? What is the problem in the body?

What is wilson disease?  What is the problem in the body?

Mutated ATP7B: The cells can't transport copper out of their cytoplasm as they should. This cases the complications of liver cell death and cirrhosis, brain damage, and so forth. ...Read more

See 1 more doctor answer
7

7
Do people with wilson disease have a lot of pain?

Do people with wilson disease have a lot of pain?

No: Movement disorder--deterioration of cognition--hepatitis---joint pain is not very significant--but they get a variety of symptom--ask your doctor. ...Read more

See 1 more doctor answer
8

8
Describe the treatments enzyme substitution in wilson disease?

Describe the treatments enzyme substitution in wilson disease?

Wilson disease: Excess opper accumulation with serious end organ damage. Treatment after diagnosis is chelation therapy to diseaseexcess copper. Then avoidance of reaccumulation. See mayo clini wilsons disease well written and presented for non medical personnel. ...Read more

See 1 more doctor answer
9

9
Hi. What is wilson disease diseas?

Hi. What is wilson disease diseas?

Copper: Wilson's disease is a disorder of copper metabolism causing too much copper in the blood and tissues. ...Read more

See 1 more doctor answer
10

10
What are the tests for wilson disease?

What are the tests for wilson disease?

It depends: Serum ceruloplasmin is often used and it is a poor choice as it misses about 30% of cases. Urine copper is my choice. If there's a family history or the diagnosis seems obvious, or urine copper is high, test the ATP7B gene. ...Read more

See 1 more doctor answer
11

11
At which age wilson disease excluded ???

No age criteria: this is a disease mainly diagnosed based on symptoms and lab results. There is no cutoff in terms of age ...Read more

12

12
What are some of the other symptoms of wilson disease?

What are some of the other symptoms of wilson disease?

Wilson Disease: The main organs affected by copper accumulation are the liver and brain, so your symptoms are refer able to these organs. You may experience cognitive impairment, bradykinesia, parkinsonian-like motor symptoms, other motor and sensory problems, fatigue, esophageal varices, liver and kidney disease, and, of course, the copper colored rings in your eyes. Cardiac involvement can also intervene. ...Read more

See 2 more doctor answers
13

13
Can you provide an overview of how wilson disease affects the liver? 

Could be bad: Wilson's disease leads to copper accumulation in the body - brain/liver/eyes and elsewhere - what it does to the liver? Well - imagine if you stuff your car engine with mud -things get, well, 'mucked up' - well that's the livers story - the liver does lots of stuff in the body - breaks down bad stuff, makes good stuff - and, is in the center of the circulation highway -so, muck up the liver and.. ...Read more

See 1 more doctor answer
15

15
I have low ceruloplasmin on blood test, so what are the chances I have wilson disease?

I have low ceruloplasmin on blood test, so what are the chances I have wilson disease?

Need more workup: Low ceruloplasmin by itself is not diagnostic of wilson disease. Decreased ceruloplasmin and blood copper concentrations and increased urine copper levels may indicate wilson disease. Definitive diagnosis may require a liver biopsy. ...Read more

See 1 more doctor answer
16

16
My dr. Says I have high copper in my blood (serum copper). Could I have wilson disease? 

My dr. Says I have high copper in my blood (serum copper). Could I have wilson disease? 

Need tests: Most cases of wilson disease show symptoms between childhood and early adulthood, some may present in their 30's and 40's. Diagnosis is made by blood, urine tests and an eye examination for kayser-fleischer rings (copper deposit around the cornea). Liver biopsy and genetic tests are also options. Not all patients experience the same set of symptoms or timeline, so thorough testing is important. ...Read more

See 2 more doctor answers
17

17
When liver enzymes started to elevated in wilson disease ??

Varies: Wilson's in infamous as an elusive diagnosis, which is unfortunate because it is so deadly if missed but easy to treat if found early. Usually the liver enzymes are up for a few years before the person gets super-sick. This the time during which we hope to make the diagnosis. ...Read more

19

19
Can prenatal vitamins or other vitamins cause wilson disease?

No: Prenatal vitamins taken during pregnancy offer more help than potential side-effects unless a woman already has a severe metabolic problem. Wilson disease is a metabolic problem causing an over accumulation of copper. Vitamins do not cause it. However, vitamins can contain an excess of certain minerals and may not be necessary in the non-pregnant state. ...Read more

See 1 more doctor answer
20

20
Should I see a specialist for wilson disease, or can my regular doctor take care of it?

It's your choice: Managing Wilson's is usually very easy and if your personal physician feels comfortable with it and knows what to watch for, and you're good with it, stay with him/her. ...Read more

See 2 more doctor answers