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How Is Progeria Genetically Transferred From Parent To Offspring
Most new mutations: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists.Most don't survive their teens.The oldest on record died at 27. ...Read more
Progeria is a rare hereditary condition affecting the blood vessels, skin and musculoskeletal system that creates the impression of accelerated aging. Some aging processes are truly accelerated such as atherosclerosis of the coronary and carotid arteries, resulting early death. Most of the other illnesses of aging such as cancer, cataracts, and dementia do not occur but deposition of a substance associated with aging, liposuction, in vital organs leads to impairment of the liver, heart, adrenal glands, brain and skeletal system. Another protein, progeria, leads to defective DNA expression and repair. This protein also enhances the development of atherosclerosis. Children with Progeria have brittle bones, pathological fractures, feeding problems, dental abnormalities, hearing loss, growth failure, hairless, and clotting problems. Characteristic ...Read more
Will vitiligo be transmitted from parent to child, either genetically or as some sort of contagion?
Is it genetically possible for a parent with sickle cell disease to have a baby without sickle trait?
Only using a donor: The offspring of someone with ss disease wil either have trait, or if the spouse has other issues could have trait plus whatever is contributed by the spouse. If the spouse has trait, ss or trait are the potential outcomes. If the baby has none of the genes of the ss parent (thru ivf etc.) they could escape the gene. ...Read more
Yes eye color is genetically chosen but I'm the only one out of both parents that have this bright gold ring around the iris is it a disease?
Does autosomal recessive polycystic kidney disease of one parent could be genetically transmissible to one of the children and what is the percentage?
None yet: There are at least three people who showed slower aging than normal. One, Brooke, was evaluated and her DNA examined. The genes responsible for Progeria were unaffected in her and the cause of her poor growth was never found, Another, now over 40 years old and depicted here, is physically like a ten year old but has no language and so far has had no etiology found for his growth ...Read moreSee 2 more doctor answers
Become informed: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care.They can also help you find support groups & other parents in the same situation. ...Read moreSee 1 more doctor answer
I found one @ 27y: The progeria syndrome is marked by early onset of ageing & noted in the written literature as far back as 1886. The life expectancy quoted in a study of 13 patients ranged from 7-27y with average of14.2 y.For a recent review of information go to: www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc2940940/?Tool=pmcentrez. ...Read more
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