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Doctor insights on: How Is Pancytopenia Developed During Aplastic Anemia

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How is pancytopenia developed during aplastic anemia?

How is pancytopenia developed during aplastic anemia?

Production stops: The body continuously recycles & replaces different cells in the blood. Red cells last ~100days, platelets several hours, other cells vary. The healthy system acheives a steady state of producing cells as fast as they break down. If an event such as a toxic exposure (chloramphenacol) or tumor invasion shuts down the "factory", no new material will be made & you get low on everything. ...Read more

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Dr. Lonnie Smith
38 doctors shared insights

Pancytopenia (Definition)

This is a decrease in all the cell lines of your blood. Meaning the white count, hemoglobin and platelets. If someone is anemic, the hemoglobin is low. If someone us thrombocytopenic, the platelet count is low. If someone is pancytopenic, all cell lines are ...Read more


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Is pancytopenia resulting from chemotherapy is same as aplastic anemia?

Is pancytopenia resulting from chemotherapy is same as aplastic anemia?

No: Aplastic anemia means something is wrong with your bone marrow and it cannot make red blood cells, white blood cells or platelets. It can be caused by toxins, infections, or autoimmune problems. Often the cause is never found. Pancytopenia from chemotherapy means a decrease in red blood cells, white blood cells and platelets caused by the toxic effect of chemo. This improves with time. ...Read more

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Is transfusion cause spleen enlarge of a thalassemia patient?

Is transfusion cause spleen enlarge of a thalassemia patient?

Not the cause: Transfusion is the treatment for Thalasemia, the splenomegaly is cause be the spleen attempting to remove the abnormal red blood cells ...Read more

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What is chemo-induced anemia?

What is chemo-induced anemia?

Bone marrow suppress: Chemotherapy can suppress the function of the bone marrow, whichnisnwherenyou make your blood cells. This can result in the development of anemia. We sometimes use stimulating agents such as Procrit (epoetin alfa) to overcome this anemia. However, these agents also have potential side effects and must be used carefully. Chemotherapy induced anemia reverses itself once the chemo is finished. ...Read more

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How common is sickle cell anemia?

How common is sickle cell anemia?

Pretty common.: 1 in every 500 african-americans, and 1 in every 900 hispanic americans. ...Read more

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What is hemoglobin f?Is anemia occur from it?

What is hemoglobin f?Is anemia occur from it?

Fetal, newborn type: There are different types of hemoglobin, and they are determined by the type of dna in one's genes. What most people have are called normal hemoglobin types, and then there are genetic mutations that create other types of "abnormal" hemoglobin (that are not as good as the normal hemoglobin). Hemoglobin f is the normal hemoglobin of fetuses and newborn babies, and f does not cause anemia. ...Read more

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What is being done to cure sickle cell anemia?

No cure: There is no cure for sickle cell anemia but you can have treatment for pain crisis ,anemia off and on as needed. ...Read more

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How rare is it to have sideroblastic anemia?

How rare is it to have sideroblastic anemia?

Ver rare: Sideroblastic anemias are a group of disorders in which hemoglobin is insufficiently synthesized, because of defective use of iron (although plasmatic iron levels may be normal or elevated). They are said to be sideroblastic because of the presence of ringed sideroblasts in the blood cells due to accumulated ferritin in mitochondria. The prevalence of RA is rare at 1 in 1000, 000. ...Read more

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What is the medecine of severe aplastic anemia?

What is the medecine  of severe aplastic anemia?

Immune therapy: Most of the medicines we use for aplastic anemia are immune modulatory in nature. We use steroids, antithyroglobulin (atg), cyclosporine, and sometimes chemotherapy. ...Read more

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What is refractory anemia with excess of blasts?

What is refractory anemia with excess of blasts?

A type of MDS: Refractory anemia with excess blasts is a type of myelodysplastic syndrome (MDS). The bone marrow will have between 5-19% blasts per high powered microscope field. This illness is a "preleukemia" or an evolving leukemia. Progression to leukemia can happen in 12 months, and many patients will require transfusions for low blood counts. Treatments can prevent progression to leukemia. ...Read more

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How is autoimmune hemolytic anemia diagnosed?

How is autoimmune hemolytic anemia diagnosed?

Bloodwork: An examination may reveal an enlarged spleen. Tests include: direct coombs' test hemoglobin in the urine indirect coombs' test red blood cell count and serum hemoglobin reticulocyte count serum bilirubin levels serum haptoglobin. ...Read more

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How are aplastic and hemolytic anemia differentiated?

How are aplastic and hemolytic anemia differentiated?

See below: Aplastic anemia is when the bone marrow stops producing blood cells. Hemolytic anemia is when red blood cells are being destroyed outside of the bone marrow. ...Read more

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How is dapsone induced hemolytic anemia treated?

How is dapsone induced hemolytic anemia treated?

Stopping dapsone: The best way to treat Dapsone related anemia is by discontinuing dapsone. Dapsone causes hemolytic anemia which is dose-dependent and can be stopped only with discontinuing the drug. Usual practice is to use the lowest possible doses of Dapsone and support with vitamin E and folic acid. ...Read more

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Is it possible for mild normocytic normochromic anemia to be caused by blood thinners?

Is it possible for mild normocytic normochromic anemia to be caused by blood thinners?

Not likely at all: That probably is not the reason for your anemia. You need further tests. ...Read more

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What is drug is given for stage 2 medistanial b cell lymphoma, is hair loss unavoidable?

What is drug is given for stage 2 medistanial b cell lymphoma, is hair loss unavoidable?

Depends on subtype: Drug combinations are usually given for b-cell lymphomas in the mediastinum. The particular subtype of lymphoma determines the drug selection. Aggressive lymphomas require chemo drugs that almost always cause hair loss. However, some "low grade" lymphomas appear in the chest and can be treated with drugs that do not require alopecia. However, hair loss is reversible, so make sure rx is curative! ...Read more

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Any one know if aplastic anemia is being cured by immunosuppressive therapy?

Any one know if aplastic anemia is being cured by immunosuppressive therapy?

Depends: Sometimes yes. Prognosis will depend on the age as well as the severity of the disease. The younger the age is the higher the respond of therapy . Bone marrow transplant can cure aplastic anemia in about 60-70%. Discuss further with your oncologist/hematologist. ...Read more

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What is anemia megaloblastica?

Megaloblastic anemia: Megaloblastic anemia (or megaloblastic anaemia) is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis during red blood cell production.[1]The defect in red cell DNA synthesis is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid. ...Read more

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How is anemia treated by a hematologist?

How is anemia treated by a hematologist?

Many causes: There are many causes of anemia. They are categorized by mechanism: blood loss, faulty or decreased red blood cell production, or destruction of red blood cells. Iron deficiency caused by blood loss is the most common. Many doctors treat common anemias by eliminating the cause (source of bleeding), prescribing supplements (iron/B12),but a hematologist is needed for more complex diagnosis/treatment ...Read more

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How is normocytic normochromic anemia a threat to someone 's life?

See below: Any type of anemia can have various complications if left untreated but it depends heavily on the type of anemia and its cause. Normocytic normochromic anemia is frequently associated with an underlying chronic disease and it is very important to diagnose this disease in order to know what the complications may be and how to treat them. ...Read more

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Dr. Steven Ginsberg
1,283 doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more


Dr. Keith Stockerl-Goldstein
80 doctors shared insights

Anemia, Aplastic (Definition)

Complete lack of blood cell reproduction. ...Read more