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Doctor insights on: How Is Pancytopenia Developed During Aplastic Anemia

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How is pancytopenia developed during aplastic anemia?

How is pancytopenia developed during aplastic anemia?

Production stops: The body continuously recycles & replaces different cells in the blood. Red cells last ~100days, platelets several hours, other cells vary. The healthy system acheives a steady state of producing cells as fast as they break down. If an event such as a toxic exposure (chloramphenacol) or tumor invasion shuts down the "factory", no new material will be made & you get low on everything. ...Read more

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Dr. Ronald Krauser
38 doctors shared insights

Pancytopenia (Definition)

This is a decrease in all the cell lines of your blood. Meaning the white count, hemoglobin and platelets. If someone is anemic, the hemoglobin is low. If someone us thrombocytopenic, the platelet count is low. If someone is pancytopenic, all cell lines are ...Read more


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Is pancytopenia resulting from chemotherapy is same as aplastic anemia?

Is pancytopenia resulting from chemotherapy is same as aplastic anemia?

No: Aplastic anemia means something is wrong with your bone marrow and it cannot make red blood cells, white blood cells or platelets. It can be caused by toxins, infections, or autoimmune problems. Often the cause is never found. Pancytopenia from chemotherapy means a decrease in red blood cells, white blood cells and platelets caused by the toxic effect of chemo. This improves with time. ...Read more

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What medications treat aplastic anemia?

What medications treat aplastic anemia?

Many: Immune suppression with drugs like steroids, cyclosporine, and anti-thymocyte globulin (horse). Bone marrow transplantation is another important type of treatment for aplastic anemia in young people. ...Read more

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What are the signs you get with aplastic anemia?

What are the signs you get with aplastic anemia?

BM failure: Aplastic anemia is caused by bone marrow failure to produce all blood cells ( affecting white cell, red blood cells as well as platelet). It can be presented with pallor, fatigue/tired, lack of energy, shortness of breath on exertion, episodes of infections, bleeding episodes, increased abdominal girth due to enlargement of spleen, etc. ...Read more

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Do they give chemotherapy for aplastic anemia?

For BMT...: Chemotherapy is given to ablate the bone marrow when you treat aplastic anemia with a bone marrow transplant. Otherwise, immunosuppressive medications are the standard of care for treatment. ...Read more

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What're the signs and symptoms of aplastic anemia?

Aplastic anemia: Usually present with significant fatigue, anemia, shortness of breath on activity, dizziness, multiple episodes of infections which could be life threatening, easy bruising, bleeding from low platelet. Discuss more in detail with your doctor. ...Read more

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Is it safe for a person with aplastic anemia to exercise?

Please ask your doct: Exercise is crucial for everyone. The amount of exercise and the type of exercise will be dependent on your blood count and your general physical condition. Your doctor may recommend just walking or gentle bike riding. The treatments for aplastic anemia may govern the types of exercise, as well. ...Read more

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What happen if my aplastic anemia getting worst? because i keep fainting several times and sometimes i can't even stand for too long.

This is serious: You will need to discuss management of your disease with your physcian. Especially if you have been told you have "aplastic anemia" at age 23 and are not fully educated about your disease and under the care of a specialist hematologist, you need to do some investigating on your own. Best wishes. ...Read more

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Can aplastic anemia be cured?

Can aplastic anemia be cured?

Possible: Aplastic anemia can be treated with immunosuppressive medications with resolution in a significant percentage of patients. Younger patients can be successfully treated with donor bone marrow transplants. ...Read more

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Can neglis aplastic anemia be cured?

What is neglis?: Regarding aplastic anemia, yes there are good treatments for it. Standard of care for a young person with severe aplastic anemia and a matched sibling donor is an hematopoietic stem cell transplant. For those without a suitable donor, immune suppression is standard of care. If you can clarify the word "neglis" for us, we are happy to provide additional info. Cheers. ...Read more

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What are the tests for aplastic anemia?

What are the tests for aplastic anemia?

Many: The most basic is the cbc, which will give you hemoglobin, hematocrit, white cell count, and platelet counts. An additional important test is a reticulocyte count which gives you the production index of red cells. Your doctor can advise you further, based on your symptoms and history. Hope this helps. ...Read more

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What sort of problem is aplastic anemia?

What sort of problem is aplastic anemia?

Aplastic anemia: Aplastic anemia is a serious problem of the blood sytem and bone marrow. The problem is that the bone marrow, where new blood cells are normally made, stops producing new cells, so you end up with low red blood cell counts, low white blood cell counts, and low platelet counts. The causes may be nutritional, cancer-related, toxin-related (eg, certain drugs), or genetic. See a hematologist. ...Read more

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What are the symptoms of aplastic anemia?

Aplastic anemia: Aplastic anemia can make all of the blood cells low. Low red cells causes anemia. The symptoms of anemia can be fatigue, dizziness, pallor, chest pain, and shortness of breath. Low white cells make the patient susceptible to fever and a variety of infections. Low platelets make one likely to have bruising, bleeding, or petechiae (small purple freckles on the skin). ...Read more

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What can you tell me about aplastic anemia?

Aplastic Anemia =: Body isn't making enough blood cells. See: http://www.mayoclinic.org/diseases-conditions/aplastic-anemia/basics/definition/con-20019296 ...Read more

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What can you do when you have aplastic anemia?

Quite a lot: Confirmed aplastic anemia is a serious condition. For severe cases treatment includes immunesuppressive drugs such as steroids, cylosporine and in younger patients (< 55 yrs old) includes donor bone marrow transplantation. In many patients long term improvements in blood counts can be obtained. ...Read more

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What is the medecine of severe aplastic anemia?

What is the medecine  of severe aplastic anemia?

Immune therapy: Most of the medicines we use for aplastic anemia are immune modulatory in nature. We use steroids, antithyroglobulin (atg), cyclosporine, and sometimes chemotherapy. ...Read more

Dr. Steven Ginsberg
1,276 doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more


Dr. Keith Stockerl-Goldstein
79 doctors shared insights

Anemia, Aplastic (Definition)

Complete lack of blood cell reproduction. ...Read more