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Doctor insights on: How Is Pancytopenia Developed During Aplastic Anemia

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How is pancytopenia developed during aplastic anemia?

How is pancytopenia developed during aplastic anemia?

Production stops: The body continuously recycles & replaces different cells in the blood. Red cells last ~100days, platelets several hours, other cells vary. The healthy system acheives a steady state of producing cells as fast as they break down. If an event such as a toxic exposure (chloramphenacol) or tumor invasion shuts down the "factory", no new material will be made & you get low on everything. ...Read more

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Dr. James Chapman
38 doctors shared insights

Pancytopenia (Definition)

This is a decrease in all the cell lines of your blood. Meaning the white count, hemoglobin and platelets. If someone is anemic, the hemoglobin is low. If someone us thrombocytopenic, the platelet count is low. If someone is pancytopenic, all cell lines are ...Read more


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Is pancytopenia resulting from chemotherapy is same as aplastic anemia?

Is pancytopenia resulting from chemotherapy is same as aplastic anemia?

No: Aplastic anemia means something is wrong with your bone marrow and it cannot make red blood cells, white blood cells or platelets. It can be caused by toxins, infections, or autoimmune problems. Often the cause is never found. Pancytopenia from chemotherapy means a decrease in red blood cells, white blood cells and platelets caused by the toxic effect of chemo. This improves with time. ...Read more

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What medications treat aplastic anemia?

What medications treat aplastic anemia?

Many: Immune suppression with drugs like steroids, cyclosporine, and anti-thymocyte globulin (horse). Bone marrow transplantation is another important type of treatment for aplastic anemia in young people. ...Read more

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What are the signs you get with aplastic anemia?

BM failure: Aplastic anemia is caused by bone marrow failure to produce all blood cells ( affecting white cell, red blood cells as well as platelet). It can be presented with pallor, fatigue/tired, lack of energy, shortness of breath on exertion, episodes of infections, bleeding episodes, increased abdominal girth due to enlargement of spleen, etc. ...Read more

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Do they give chemotherapy for aplastic anemia?

For BMT...: Chemotherapy is given to ablate the bone marrow when you treat aplastic anemia with a bone marrow transplant. Otherwise, immunosuppressive medications are the standard of care for treatment. ...Read more

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What're the signs and symptoms of aplastic anemia?

Aplastic anemia: Usually present with significant fatigue, anemia, shortness of breath on activity, dizziness, multiple episodes of infections which could be life threatening, easy bruising, bleeding from low platelet. Discuss more in detail with your doctor. ...Read more

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Is it safe for a person with aplastic anemia to exercise?

Please ask your doct: Exercise is crucial for everyone. The amount of exercise and the type of exercise will be dependent on your blood count and your general physical condition. Your doctor may recommend just walking or gentle bike riding. The treatments for aplastic anemia may govern the types of exercise, as well. ...Read more

Dr. Steven Ginsberg
1,239 doctors shared insights

Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more


Dr. Keith Stockerl-Goldstein
72 doctors shared insights

Anemia, Aplastic (Definition)

Aplastic anemia is a failure of the bone marrow to produce blood cells for the body, including white blood cells. ...Read more