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How Is Down Syndrome Transmitted From Parent To Offspring
In most cases: The basic risk of a female having a ds offspring increases from a low in the early 20's (1/2000) to 1/100 @40 & 1/12 @ 49.Chromosome origination studies suggest the anomaly ares in egg rather than the sperm, likely because a blighted sperm doesn't swim as effectively.Age is therefore less an issue for the male. In rare translocation ds, gender is not as much an issue. ...Read more
Down syndrome is a genetic condition in which there is an extra chromosome present. Symptoms may range from mild to severe. Children with Down syndrome share a common physical appearance including a flattened nose, small ears, a small mouth, upward slanting eyes, and a single crease in the ...Read more
What is the risk of a trisomy 21 parent passing on the condition to his/her offspring? Should adults with Down syndrome be dissuaded from reproducing
Is there a type of mosaic Down syndrome that doesn't require the mutation to come from either parent to have a downs child?
Yes: A mosaic down syndrome child can come from a normal egg and normal sperm, produced by normal parents. The fertilized egg would start out normal with 46 chromosomes. It can divide into 2 normal cells, which themselves divide again. If on one of the early divisions, one cell ends up with an extra #21 chromosome and survives to continue dividing, the child will be mosaic with some trisomy 21 cells. ...Read moreSee 1 more doctor answer
If my grandma have Down syndrome and me and my parents don't, is it possible that my child have down syndrome?
Unlikely: The traditional 21 ds female is capable of having healthy babies and at least half would not have ds. Those healthy babies would not have more than 1% risk having a ds kid nor would their kids. Less than 2% of ds patients are balanced carriers of an extra piece or a 21, and the chance that they would have any normal kids (your parent) approaches zero. ...Read moreSee 1 more doctor answer
Confusing question: Certainly women with down syndrome are fertile, achieving puberty at the same time as most of their age group.They can have infants that are both normal and have down syndrome. The question is an articulate one, more so than some of the physician answers. You appear to be stating ds skipped a generation in your family.Unless yours is a mosaic form, i doubt you are ds, ?Who is writing this? ...Read moreSee 1 more doctor answer
How long does a Down syndrome person usually live? Is that a problem since parents are usually old?
6 decades +: Years ago the expected lifespan for ds kids was short, due to a combination of heart defects, increased vulnerability to infection & lack of aggressive management. Today the projected lifespan exceeds 6 decades.Ds is a prime example of the need for survivor assistance planning. Various ds support groups, the "arc", social workers all help families integrate public & private support. ...Read more
Wouldn't happen: Although DS girls enter puberty and become fertile the male rarely if ever achieves this status. DS females have offspring after conception by normal males, usually from abuse or incest.These are roughly half normal and half DS.Males with DS rarely if ever achieve a fertile status and because of this outcome would be unknown if ever conceived. ...Read more
Can extremely high sugar level in a male lead to (down syndrome) in his offspring. We are so scared of making babies.
No: Males get a bit of a pass on the ds issue.You make millions of sperm that are constantly renewed and only the healthiest sperm swim well enough to conceive.Any weak ones wouldn't do the deed. Women present only one egg at a time and those show the accumulated effect of toxins an the like. You may benefit from talking with a genetic counselor to explore any risk issues. ...Read moreSee 1 more doctor answer
If someone in your family has down syndrome, is there a larger risk that your baby will have down syndrome?
Slight risk: Most down syndrome is sporadic. A few patients with down syndrome have the extra 21 chromosome translocated on to another chromosome. In some of these cases the parents can carry the translocated chromosome in a balanced form and they and other family members could be at increased risk to have children with the syndrome. ...Read moreSee 2 more doctor answers
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