Doctor insights on:
How Is A Baby Born With The Sickle Cell Trait When Neither Parents Has It
New mutation: Sickle cell trait is almost always caused by a gene passed down from one parent. The parent may not even know he or she has it. Rarely, a new mutation can also occur-- a child's gene changes on its own, meaning that they didn't get it from a parent. I could not find the exact rate of these new mutations. It's rare, but it can at least theoretically happen. ...Read more
You test both to see: This is a simple test, a hemoglobin electrophoresis. If a kid has trait, at least one or possibly both parents may have it. It would be quite rare for the kid to have a new mutation and neither parent have it. ...Read more
If one parent has the sickle cell trait and the other is normal, is it possible that their child can get the sickle disease?
99+% yes: The answer is yes, but there is always a chance of a new mutation (rare). In which case one of the parents might not have trait. There is also hemoglobin c which can combine with hemoglobin s to give a very similar clinical disease (hemoglobin sc disease). You can also have sickle beta thalassemia which is very similar to sickle cell disease. But only one parent has to have sickle trait. ...Read more
Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc?
One has S/One has C: Parents have 2 genes at a given gene location in their dna. They have a carrier state if one gene is normal and one abnormal. In sickle trait the pair is sn, in c trait the pair is cn. For a child to have sc (sickle c) they get the s from one and the c from the other. If one parent is sc and the other sn (sickle trait), you could have ss, sn or sc. ...Read more
Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc or not?
Sort of: Sickle cell disease can include at least 3 different conditions. 2 parents with sickle trait can have a child with sickle cell anemia. 1 parent with sickle trait and 1 with hemoglobin c trait, another abn hgb, have a 1/4 chance of a child with sc disease, while 1 with sickle trait and 1 with thalassemia trait have a 1/4 chance of a child with sickle/thalassemia. All are called sickle cell disease. ...Read more
Highly unlikely...: It is theoretically possible for someone to acquire a new mutation (de novo mutation) that is not inherited from a parent, but this has not been described for the sickle cell mutation. Statistically speaking, if you have sickle cell trait, one your biological parents also has to have it. ...Read more
Three possibilities: They each carry a pair of sickle related genes (one normal one bad), one of which would be passed to any child. They could have all affected sickle cell kids, all with no sickle genes, all trait or some mix of the three. The risk percentage is a confusing concept. Just because you have inly 25% risk of a SS kid doesn't mean it comes out that way, every conception is a separate risk & all can be SS ...Read more
How likely am I to have sickle cell trait if my parents, grandparents, and greatgrandparents are nonafrican?
Genetic condition: While it is true that sickle cell in most common in those with african ancestry, people from other locations can carry the gene. The more important factor is not whether your ancestors are non-african but whether they carry the gene for sickle cell. If they don't, then you cannot get the condition. ...Read more
Not really: If it were not for the newborn screening done in all states we would not pick up these kids in childhood. These kids have pretty normal lives. If/ when their parents are aware they carry trait, we would look for it at some point but there would not be any urgency beyond the desire to know. ...Read more
Is it genetically possible for a parent with sickle cell disease to have a baby without sickle trait?
Only using a donor: The offspring of someone with ss disease wil either have trait, or if the spouse has other issues could have trait plus whatever is contributed by the spouse. If the spouse has trait, ss or trait are the potential outcomes. If the baby has none of the genes of the ss parent (thru ivf etc.) they could escape the gene. ...Read more
Yes: Or one with trait and one with ss. ...Read more
Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?
I don't have the sickle cell trait but the father of my baby does, so what's the worst that could happen to my baby?
Yes: The trait for sickle cell hemoglobin can come from either parent. ...Read more
Supposing someone's mother is greek/macedonian and their father is african-american/dominican, what's the chance of the child getting the sickle cell trait?
Testing for parents: Only way to know is for parents to be tested first. Any ethnicity can carry the gene for sickle cell. To get sickle cell trait, just one of the parents needs to also have it. In this case, the child has 50% chance of inheriting it. If one of the parents has sickle cell disease, 100% chance that child will get trait. If both parents trait, then 25% no trait, 25% sickle cell disease, 50% trait. ...Read more
Unsure: If you're asking whether sickle trait makes it harder for you to have a baby, the answer is no. If you're asking whether having this makes it harder for you to adopt a baby, no again. Have an effect on the baby? Possibly. If the other parent has 2 normal beta genes (no s, c, thalassemia) then the baby has a 50% chance of having trait. Partner has a hemoglobin problem too? Talk to your doctor! ...Read more
Not necessarily: If you and your partner both have sickle cell trait, there is a 25% chance your child will be normal (not have sickle cell trait or anemia), a 50% chance they will have sickle cell trait (just like you and your partner), and a 25% chance they will have sickle cell disease. Prenatal diagnosis is available early in pregnancy that will tell you what your child has. ...Read more
If me and boyfriend both have sickle cell trait, how will we prevent our children from having full sickle cell anemia?
Nothing: Unfortunately, there would be 25% chance for your child to have sickle cell disease and 50% chance for sickle cell trait. With our technology now, nothing can alter the risk. Sorry to say, the only thing for somebody with sickle cell trait to completely prevent any possibility of having a biological child with sickle cell disease is by having a child with somebody with normal hb. ...Read more
My son has the sickle cell trait and neither his father or me have the trait. This is confirmed. How is this possible please?
New mutation: I am going to assume that a real lab study has confirmed this by hemoglobin electrophoresis and this is not a sample switch, tech error, or other cause of a bad result. Since Junior is going to ask questions, I would urge for the family's sake to do the genetic studies to confirm paternity. You are brave to ask. Best wishes. ...Read more
Yes.: Pain crisis and even worse complications can occur in people with sickle cell trait. It is more likely to occur when dehydrated and when experiencing altitude changes. I have seen this be a problem when someone with sickle cell trait comes from sea level to the mountains for vacation. Important to stay well hydrated. ...Read more
Sickle trait: Sickle trait means one copy of hemoglobin carries the mutation for sickle cell disease and the other copy is unaffected. Most people with sickle trait are unaffected by this. For athletes with sickle trait, it is essential to keep well hydrated. See http://www. Cdc. Gov/ncbddd/sicklecell/traits. Html for good recommendations. ...Read more
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