Top 20 Doctor insights on: How is a baby born with the sickle cell trait when neither parents has it

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How is a baby born with the sickle cell trait when neither parents has it?

How is a baby born with the sickle cell trait when neither parents has it?

New mutation: Sickle cell trait is almost always caused by a gene passed down from one parent. The parent may not even know he or she has it. Rarely, a new mutation can also occur-- a child's gene changes on its own, meaning that they didn't get it from a parent. I could not find the exact rate of these new mutations. It's rare, but it can at least theoretically happen. ...Read more

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Dr. James Lin
75 Doctors shared insights

Sickle Cell Carrier (Definition)

Sickle cell carrier has gen for disease so if get married with some body with the same gene they will have children ...Read more


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Could both parents have to have the sickle cell trait for the child to have sickle cell anemia?

Could both parents have to have the sickle cell trait for the child to have sickle cell anemia?

Yes: Sickle cell anemia requires the gene from both parents to cause ss anemia. If only one parent gave the gene, the kid would be a trait carrier. ...Read more

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Do both parents have to have the sickle cell trait for the child to have sickle cell anemia?

Do both parents have to have the sickle cell trait for the child to have sickle cell anemia?

No: 2 abnormal (sickle cell) gene have to be inherited to have sickle cell disease. This can happen if both patents have sickle cell trait, one parent has sickle cell disease or both have sickle cell disease. ...Read more

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If a child has sickle cell anemia, wouldn't both the parents need to have sickle cell trait?

If a child has sickle cell anemia, wouldn't both the parents need to have sickle cell trait?

No: There are varying forms of sickling diseases, however it is a recessive trait and so the parents may appear fine but carry the trait and yet have a child with the disease. ...Read more

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How do you known which parent give the child the sickle cell trait?

How do you known which parent give the child the sickle cell trait?

You test both to see: This is a simple test, a hemoglobin electrophoresis. If a kid has trait, at least one or possibly both parents may have it. It would be quite rare for the kid to have a new mutation and neither parent have it. ...Read more

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If one parent has the sickle cell trait and the other is normal, is it possible that their child can get the sickle disease?

No: Both parents need to pass the genes, so if only one of you have the sickle trait (only 1 gene for sickle) then the baby will not have sickle cell disease. He can get the trait and be able to pass it on to his/her children. ...Read more

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Can a child have sickle cell trait if neither parent has it but the paternal grandfather does?

No: Both parents may need a repeat hemoglobin electrophoresis as it is likely that one of the biological parents have at least a sickle cell trait which is usually asymptomatic ...Read more

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Should parents have any problems raising a child with sickle cell trait?

Should parents have any problems raising a child with sickle cell trait?

Very unlikely: Most children with sickle trait are asymptomatic except their hemoglobin levels, so called iron count, stay a bit lower than normal. ...Read more

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Do both parents have to have sickle cell trait in order for their child to have sickle disease?

99+% yes: The answer is yes, but there is always a chance of a new mutation (rare). In which case one of the parents might not have trait. There is also hemoglobin c which can combine with hemoglobin s to give a very similar clinical disease (hemoglobin sc disease). You can also have sickle beta thalassemia which is very similar to sickle cell disease. But only one parent has to have sickle trait. ...Read more

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Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc?

Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc?

One has S/One has C: Parents have 2 genes at a given gene location in their dna. They have a carrier state if one gene is normal and one abnormal. In sickle trait the pair is sn, in c trait the pair is cn. For a child to have sc (sickle c) they get the s from one and the c from the other. If one parent is sc and the other sn (sickle trait), you could have ss, sn or sc. ...Read more

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Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc or not?

Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc or not?

Sort of: Sickle cell disease can include at least 3 different conditions. 2 parents with sickle trait can have a child with sickle cell anemia. 1 parent with sickle trait and 1 with hemoglobin c trait, another abn hgb, have a 1/4 chance of a child with sc disease, while 1 with sickle trait and 1 with thalassemia trait have a 1/4 chance of a child with sickle/thalassemia. All are called sickle cell disease. ...Read more

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Is it possible that neither of my parents can have the sickle cell trait but I do?

Highly unlikely...: It is theoretically possible for someone to acquire a new mutation (de novo mutation) that is not inherited from a parent, but this has not been described for the sickle cell mutation. Statistically speaking, if you have sickle cell trait, one your biological parents also has to have it. ...Read more

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Can you get the sickle cell trait from just one parent?

Can you get the sickle cell trait from just one parent?

YES: By definition, a trait comes from only one parent, in that one has inherited a single copy of the defective hemoglobin gene hemoglobin s. If one inheirits the gene from both parents, then one has sickle cell disease, not sickle trait. ...Read more

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If two parents have sickle cell trait, what will their children have?

If two parents have sickle cell trait, what will their children have?

Three possibilities: They each carry a pair of sickle related genes (one normal one bad), one of which would be passed to any child. They could have all affected sickle cell kids, all with no sickle genes, all trait or some mix of the three. The risk percentage is a confusing concept. Just because you have inly 25% risk of a SS kid doesn't mean it comes out that way, every conception is a separate risk & all can be SS ...Read more

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How likely am I to have sickle cell trait if my parents, grandparents, and greatgrandparents are nonafrican?

Genetic condition: While it is true that sickle cell in most common in those with african ancestry, people from other locations can carry the gene. The more important factor is not whether your ancestors are non-african but whether they carry the gene for sickle cell. If they don't, then you cannot get the condition. ...Read more

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Are there any symptoms of sickle cell trait in babies?

Are there any symptoms of sickle cell trait in babies?

Not really: If it were not for the newborn screening done in all states we would not pick up these kids in childhood. These kids have pretty normal lives. If/ when their parents are aware they carry trait, we would look for it at some point but there would not be any urgency beyond the desire to know. ...Read more

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Is it genetically possible for a parent with sickle cell disease to have a baby without sickle trait?

Is it genetically possible for a parent with sickle cell disease to have a baby without sickle trait?

Only using a donor: The offspring of someone with ss disease wil either have trait, or if the spouse has other issues could have trait plus whatever is contributed by the spouse. If the spouse has trait, ss or trait are the potential outcomes. If the baby has none of the genes of the ss parent (thru ivf etc.) they could escape the gene. ...Read more

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Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?

Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?

NO: To simplify- providing that the father has a completely normal blood - (no other type of congenital/hereditary bood disorder-like thalasemia minor, hemoglobin c disease etc) - the baby will have 50% risk to have sickle cell trait-but the baby will not have sickle cell anemia. ...Read more

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I don't have the sickle cell trait but the father of my baby does, so what's the worst that could happen to my baby?

I don't have the sickle cell trait but the father of my baby does, so what's the worst that could happen to my baby?

Trait ++: If we assume that neither you of babies dad has any other gene problems, baby has 50% chance of getting trait. Baby also has the 4% chance every baby has for having some unexpected issue at delivery, including prematurity, illness, need for ICU care, birth injury, etc. ...Read more

Dr. James Ball
355 Doctors shared insights

Sickle Cell Disease (Definition)

A group of disorders that cause red blood cells to become ...Read more