Top 20 Doctor insights on: How is a baby born with the sickle cell trait when neither parents has it
New mutation: Sickle cell trait is almost always caused by a gene passed down from one parent. The parent may not even know he or she has it. Rarely, a new mutation can also occur-- a child's gene changes on its own, meaning that they didn't get it from a parent. I could not find the exact rate of these new mutations. It's rare, but it can at least theoretically happen. ...Read moreSee 1 more doctor answer
You test both to see: This is a simple test, a hemoglobin electrophoresis. If a kid has trait, at least one or possibly both parents may have it. It would be quite rare for the kid to have a new mutation and neither parent have it. ...Read more
If one parent has the sickle cell trait and the other is normal, is it possible that their child can get the sickle disease?
99+% yes: The answer is yes, but there is always a chance of a new mutation (rare). In which case one of the parents might not have trait. There is also hemoglobin c which can combine with hemoglobin s to give a very similar clinical disease (hemoglobin sc disease). You can also have sickle beta thalassemia which is very similar to sickle cell disease. But only one parent has to have sickle trait. ...Read more
Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc?
One has S/One has C: Parents have 2 genes at a given gene location in their dna. They have a carrier state if one gene is normal and one abnormal. In sickle trait the pair is sn, in c trait the pair is cn. For a child to have sc (sickle c) they get the s from one and the c from the other. If one parent is sc and the other sn (sickle trait), you could have ss, sn or sc. ...Read moreSee 1 more doctor answer
Do both parents have to have the actual sickle cell trait in order for the child to have sickle disease sc or not?
Sort of: Sickle cell disease can include at least 3 different conditions. 2 parents with sickle trait can have a child with sickle cell anemia. 1 parent with sickle trait and 1 with hemoglobin c trait, another abn hgb, have a 1/4 chance of a child with sc disease, while 1 with sickle trait and 1 with thalassemia trait have a 1/4 chance of a child with sickle/thalassemia. All are called sickle cell disease. ...Read moreSee 2 more doctor answers
Highly unlikely...: It is theoretically possible for someone to acquire a new mutation (de novo mutation) that is not inherited from a parent, but this has not been described for the sickle cell mutation. Statistically speaking, if you have sickle cell trait, one your biological parents also has to have it. ...Read moreSee 1 more doctor answer
Three possibilities: They each carry a pair of sickle related genes (one normal one bad), one of which would be passed to any child. They could have all affected sickle cell kids, all with no sickle genes, all trait or some mix of the three. The risk percentage is a confusing concept. Just because you have inly 25% risk of a SS kid doesn't mean it comes out that way, every conception is a separate risk & all can be SS ...Read moreSee 1 more doctor answer
How likely am I to have sickle cell trait if my parents, grandparents, and greatgrandparents are nonafrican?
Genetic condition: While it is true that sickle cell in most common in those with african ancestry, people from other locations can carry the gene. The more important factor is not whether your ancestors are non-african but whether they carry the gene for sickle cell. If they don't, then you cannot get the condition. ...Read more
Not really: If it were not for the newborn screening done in all states we would not pick up these kids in childhood. These kids have pretty normal lives. If/ when their parents are aware they carry trait, we would look for it at some point but there would not be any urgency beyond the desire to know. ...Read more
Is it genetically possible for a parent with sickle cell disease to have a baby without sickle trait?
Only using a donor: The offspring of someone with ss disease wil either have trait, or if the spouse has other issues could have trait plus whatever is contributed by the spouse. If the spouse has trait, ss or trait are the potential outcomes. If the baby has none of the genes of the ss parent (thru ivf etc.) they could escape the gene. ...Read more
Can a father with normal blood and a mother with sickle cell trait have a child with sickle cell anemia?
I don't have the sickle cell trait but the father of my baby does, so what's the worst that could happen to my baby?
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