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Doctor insights on: How Does Thyroxine Affect Metabolism

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Dr. David Sneid
1,422 Doctors shared insights

Thyroxine (Definition)

Thyroxine is a thyroid agent. ...Read more


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Once you begin taking Synthroid are you obligated to it forever? Recently, I skipped my levothyroxin 100mcg for 5 days. Before being prescibed and since I have had a slow metabolism. It seems that the 5 day break gave my metabolism a jump-start. Could thi

Once you begin taking Synthroid are you obligated to it forever? Recently, I skipped my levothyroxin 100mcg for 5 days. Before being prescibed and since I have had a slow metabolism. It seems that the 5 day break gave my metabolism a jump-start. Could thi

Thyroid forever: If you have acquired hypothyroidism you can never naturally regain your ability to manufacture naturally the thyroid hormone. This may be the most common medical diagnosis in american medicine. And, it means that you will need to take a daily thyroid replacement for as long as you live. ...Read more

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I take 50 mg of levothyroxine but my weight creeping up and up even with diet and excercise. Do I need to take more dose to higher my metabolism?

I take 50 mg of levothyroxine but my weight creeping up and up even with diet and excercise. Do I need to take more dose to higher my metabolism?

No: Your dose of thyroid medication should be adjusted based on your lab tests. Your weight may or may not be related to your thyroid level. To loose weight you will need to burn off more calories than you take in. Take a close look at your activity level and total calorie intake. A good start is to keep intake below 1500 calories ...Read more

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Does 25mcg of levothyroxine raise one's metabolism? I'm taking it to treat my hypo (which it does). But I'm hoping it'll speed up weight loss? ?

Does 25mcg of levothyroxine raise one's metabolism? I'm taking it to treat my hypo (which it does). But I'm hoping it'll speed up weight loss? ?

Not exactly: 25 mcg of levothyroxine is a rather small dose. To expect that to raise your metabolism is not realistic. But then the dose you need depends on how hypothyroid you are. You just do not take the medication to raise metabolism if you are not hypothyroid. ...Read more

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T have a headache. Could Synthroid (thyroxine) be the cause?

T have a headache. Could Synthroid (thyroxine) be the cause?

Very unlikely: Synthroid is giving you levothyroxine, a naturally occurring compound that the thyroid normally makes. It is remotely possible (< 1% chance) that the headache could be due to a reaction to the dye in the pills. If so, then switching to 50 mcg pills (may need more than 1 per day) would eliminate the headaches. ...Read more

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If Synthroid (thyroxine) isn't working, would armour work better because it isn't synthetic?

If Synthroid (thyroxine) isn't working, would armour work better because it isn't synthetic?

No: Synthroid (thyroxine) takes several weeks to take effect. You need to be patient and follow your doctors instructions. The dose will probably need to be adjusted over the next several months. Armour is an outdated form of treatment for hypothyroidism and is not as effective. ...Read more

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If I have been using Synthroid (thyroxine) for years and it isn't working, should I ask about armour or something not synthetic?

If I have been using Synthroid (thyroxine) for years and it isn't working, should I ask about armour or something not synthetic?

There is: No such thing as Synthroid (thyroxine) "not working". If you take the proper dose to keep your levels normal, it's working. If you have other problems, they are not due to your hypothyroidism. Synthroid (thyroxine) is an exact duplicate of what your own thyroid makes. Armour thyroid is ground up pig glands that are not standardized, not testable by routine lab and dangerous. ...Read more

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I am taking Synthroid (thyroxine) 25 mg. I have been loosing weight. I don't think this dosage is high enough. And why am I loosing weight.

I am taking Synthroid (thyroxine) 25 mg. I have been loosing weight. I don't think this dosage is high enough. And why am I loosing weight.

That is a very small: Dose of Synthroid (thyroxine). Best to check your T4 and TSH levels
at your doctor's lab. With this information your dose may be adjusted to correct the weight loss. Bear in mind that other factors may be involved in weight loss. Best of health. ...Read more

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What will happen if I don't take my thyroxine medication?

What will happen if I don't take my thyroxine medication?

Hypothyroid: Hi. If you're hypothyroid and don't take your l-thyroxine, you'll be untreated hypothyroid...but somehow, I betcha knew that! ...Read more

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Is there an alternative to Synthroid (thyroxine) that doesn't have to be taken daily?

Is there an alternative to Synthroid (thyroxine) that doesn't have to be taken daily?

Possible: Levothyroxine (t4) has a long 1/2 life (up to 10 days in new hypothyroidism) so it is possible to dose a higher dose less often (e.g. 100mcg every other day). The problem we run into is compliance issues: many patients tend to forget to take their pills unless it is given once daily. ...Read more

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I'm on 100mc Synthroid (thyroxine) my th levels are normal but it seems I still can't make it through the day?

I'm on 100mc Synthroid (thyroxine) my th levels are normal but it seems I still can't make it through the day?

Define normal: There is a lot of controversy about what exactly constitutes "normal" thyroid labs. If the TSH is between 0.5 and 2.5, I agree that it is time to look for for other causes. If above or below this, adjusting the thyroid dose to tweak the TSH into this range may improve your symptoms. ...Read more

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My dr priscribed me 37.5mcg thyroxine dose. I don't want cut 75mcgpill so can I take 75mcg pill every second day for same result?

My dr priscribed me 37.5mcg thyroxine dose. I don't want cut 75mcgpill so can I take 75mcg pill every second day for same result?

Yes: Thyroid hormone has a very long "half-life". It will make no difference taking 75 mcg very other day vs 1/2 pill every day. However, a dose of 37.5 mcg daily is a very small dose for someone in your age group. If 75 mcg was too high a dose, you could be on 50 mcg as the next step down. ...Read more

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Fnp wants to raise my Synthroid (thyroxine) from 50 mcg to 75. I don't understand the mechanics behind this medicine. Can you explain?

Fnp wants to raise my Synthroid (thyroxine) from 50 mcg to 75. I don't understand the mechanics behind this medicine. Can you explain?

TSH: Hi. Your FNP probably tested your TSH and found it to be high on your current dose of 50 mcg/day. TSH is the pituitary hormone that reflects thyroid status (assuming normal pituitary function); if TSH is hi, your pituitary is trying to push your thyroid to make more thyroid hormone, but your thyroid is damaged and can't. Therefore, you give more Synthroid (thyroxine) until the TSH is down in the normal range ...Read more

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My dr priscribed me 37.5mcg thyroxine but I can't cut 75mcg pill equal so can I take 75mcg pill every other day for same result it is right?

My dr priscribed me 37.5mcg thyroxine but I can't cut 75mcg pill equal so can I take 75mcg pill every other day for same result it is right?

37.5: 75 every day should be OK.
When you get your next meds from your pharmacy make sure there is a line down the middle of the pill that makes it easy to break (not cut) in two. ...Read more

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I haven't taken my Synthroid (thyroxine) in about a month. Since that month I have gained 25lbs. Is it because I'm off my synthroid (thyroxine)?

I haven't taken my Synthroid (thyroxine) in about a month. Since that month I have gained 25lbs. Is it because I'm off my synthroid (thyroxine)?

Probably two reasons: If you have been prescribed synthroid or levothyroxine replacement therapy, then your body likely needs thyroid hormone therapy to maintain normal thyroid levels. When you stop synthroid, and the thyroid levels become very low, you can then gain weight from two major factors: fluid retention, and slowed metabolism. Please check with your doctor to discuss what dose of synthroid you should restart. ...Read more

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I started synthroid (thyroxine) 25 mcg 2.5 wks ago for hypo. The last few days, I've felt very full (almost sick) when I don't eat much. Is this related? Why?

Unrelated: You've started on the smallest dose of Synthroid (thyroxine) and is certainly not causing early satiety. If this feeling doesn't pass in the next few days, go c ur doc. ...Read more

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Any reason why can thyroxine be taken orally, but insulin can't?

Any reason why can thyroxine be taken orally, but insulin can't?

Insulin is digested: Thyroxine is a small molecule similar to an aminoacid and it gets absorbed intact from the gut. When circulating it then behaves like naturally produced thyroxine. Insulin is a protein digested/broken down into dipeptides and aminoacids. Obviously once broken down and absorbed into the bloodstream it no longer exists as the intact molecule which is needed for its hormonal function. ...Read more

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Is cytomel safe to take? I don't feel Synthroid (thyroxine) is enough because I still feel bad

Is cytomel safe to take? I don't feel Synthroid (thyroxine) is enough because I still feel bad

Go to your doctor: Cytomel (liothyronine) is mainly for supplementation of your t3, which is way more potent than your T4 and is the end product of your t4. Be careful in taking medicines that your doctor has not prescribed as if you cause hyperthyroidism, your heart status can also suffer. It is best to have your level checked and medicine adjusted. ...Read more

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If I miss my Synthroid (thyroxine) 125 mg over the weekend because I forgot to pick up my meds on friday and don't pick them up until monday will it do any harm?

No: I don't think it will if it's only for few days onetime only. But if you do this frequently then it will. When you go back home take an extra half tablet for 2 days. ...Read more

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I have hashimotos and can't seem to lose weight. I am on synthroid (thyroxine). I tried diet. Exercise. Everything! Nothing works. I lose 5 pounds that's it. Help?!

I have hashimotos and can't seem to lose weight. I am on synthroid (thyroxine). I tried diet. Exercise. Everything! Nothing works. I lose 5 pounds that's it. Help?!

If you are: Biochemically euthyroid (meaning your blood work shows normal thyroid levels), you should calculate your basal energy expenditure (bee) and subtract 500kcal from that number to have a goal number of calories to eat per day. If that does not work, you could also discuss with your doctor the possibility of converting to t4/t3 combination replacement. ...Read more

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I hv never had high bp- I am on no meds other than my. 25 mg of synthroid, (thyroxine) it has been 167-99to 157-99-a few times it was 117-79--I don't understand?

I hv never had high bp- I am on no meds other than my. 25 mg of synthroid, (thyroxine) it has been 167-99to 157-99-a few times it was 117-79--I don't understand?

You need to see: Your doctor for an evaluation and possible treatment for hypertension. Also, hopefully you're on 25 micrograms of Synthroid, (thyroxine) not 250 micrograms (.25mg), which would be a very high dose. ...Read more

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I have been on Synthroid (thyroxine) for 20 years I am up to 112 I took the nucleous medison 20 years ago I can't lose weight I weight 197lbs iwalk 5days a week?

Rule out hashimoto's: Good chance you have hashimoto's thyroiditis, autoimmune disorder, closely related to gluten sensitivity. 1st get a blood test for thyroperoxidase antibodies, then off gluten, on vit. D 10000 u./day. Seek help from holistic md, preferably functional medicine specialist. ...Read more

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What stops thyroxine from working?

What stops thyroxine from working?

When you stop taking: Thyroxin stops working only when you stop taking it. ...Read more

Dr. Joseph Mathews
618 Doctors shared insights

Synthroid (Definition)

Synthroid is a thyroid agent. ...Read more


Dr. Charles Gordon
219 Doctors shared insights

Levoxyl (Definition)

Levoxyl is a thyroid agent. ...Read more