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Doctor insights on: How Does The Drug Carbidopa Affect Levodopa

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How does the drug carbidopa affect levodopa?

How does the drug carbidopa affect levodopa?

Blocks breakdown: Carbidopa acts to block the enzyme aromatic-l-amino-acid decarboxylase which converts l-dopa to dopamine. Since it cannot get into the brain it works in the rest of the body (periphery). When given in combination with l-dopa in parkinson's disease, it inhibits the conversion of l-dopa to Dopamine in the body so that more is available to be converted in the brain where it is needed. ...Read more

Carbidopa (Definition)

Dopamine is a necessary neurotransmitter in the basal ganglia of our brains, and in parkinson's, there is a deficiency. We supplement l-dopa, to replace, but since the body might break down our oral med, we add Carbidopa which prolongs the benefit ...Read more


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What is the difference between Parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?

What is the difference between Parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?

COMT inhibitor: Entacaptone is a selective catecholamine-o methyl transferase (comt) inhibitor that increases the bioavailabilty of dopamine. Like Carbidopa in sinemet it does not cross the blood brain barrier. Stalevo (carbidopa and levodopa and entacapone) is a combination of l dopa, Carbidopa and entacaptone. Sinemet is a combination of Carbidopa and l-dopa. ...Read more

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My mom, Safia, 60 years old, resident of Pakistan has drug induced parkinsonism, which is bothering a lot & worsening. Sinemet (carbidopa and levodopa) 25/250 every 4.5 hours?

My mom, Safia, 60 years old, resident of Pakistan has drug induced parkinsonism, which is bothering a lot & worsening. Sinemet (carbidopa and levodopa) 25/250 every 4.5 hours?

Tachyphylaxis.: Dosing of Sinemet (carbidopa and levodopa) is a little strange, requiring front loading in the day and a long gap at night without dosing. If taken like most other medications, on a more regular dosing interval, tachyphylaxis develops, which essentially means the efficacy of the medication reduces. ...Read more

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Is it safe to take clonazepam for sleep with sinemet (carbidopa and levodopa) for Parkinsons patient? Are there any drug interactions?

Is it safe to take clonazepam for sleep with sinemet (carbidopa and levodopa) for Parkinsons patient? Are there any drug interactions?

Probably safe...: ...but not especially the best choice! Although medications in that class (benzodiazepines) allay anxiety and can relax muscle spasm, they also interfere with normal sleep architecture and increase the risk of falling. I would certainly advise that you discuss this with your neurologist or a psychiatrist trained in sleep disorders or with additional training in geropsychiatry. ...Read more

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What happens if I take carbidopa and levodopa?

What happens if I take carbidopa and levodopa?

See below: Carbidopa-levodopa is a generic medication for Parkinson's disease and helps dopamine brain connections. Why would you want to take this if you do NOT have Parkinson's?? ...Read more

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Please describe the medication: sinemet (carbidopa and levodopa)?

Please describe the medication: sinemet (carbidopa and levodopa)?

Carbidopa/levodopa: Sinemet (carbidopa and levodopa) is a combination drug that contains Carbidopa and levodopa. It is most commonly prescribed for parkinson's disease but may also be prescribed for other conditions including restless legs syndrome. ...Read more

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What does sinemet (carbidopa and levodopa) consist of and what is cr?

See below: Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. ...Read more

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What is the typical dosage of sinemet (carbidopa and levodopa) cr?

What is the typical dosage of sinemet (carbidopa and levodopa) cr?

Sinemet-CR: This has to be determined by careful titration thru your doctor. Initial dose is usually 50-200. Consult your Neurologist. ...Read more

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I took 9 sinemet (carbidopa and levodopa) tablet a day, is that to much?

Sinemet (carbidopa and levodopa): Not sure what milligram each, but if that's what your doctor prescribed & your symptoms are under control & you are tolerating the medication well, then you should be ok. ...Read more

Levodopa (Definition)

A drug which when it gets into the brain is converted to Dopamine that ...Read more