Doctor insights on:
How Does The Drug Carbidopa Affect Levodopa
Blocks breakdown: Carbidopa acts to block the enzyme aromatic-l-amino-acid decarboxylase which converts l-dopa to dopamine. Since it cannot get into the brain it works in the rest of the body (periphery). When given in combination with l-dopa in parkinson's disease, it inhibits the conversion of l-dopa to Dopamine in the body so that more is available to be converted in the brain where it is needed. ...Read more
Increased IOP: While levodopa/carbidopa primarily is a dopaminergic agent, there may be cross-over onto cholinergic receptors. These receptors are generally responsible for pupil dilation which can cause narrowing of the angle which can increase eye pressure. A laser iridotomy may help in some cases but not all. The medication could be tried if needed, with careful supervision by an ophthalmologist. ...Read moreSee 1 more doctor answer
Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach. ...Read more
How does levodopa/carbidopa cause a rise in intraocular pressure? I understand that it can cause an acute rise in that pressure but how?
Maybe: Vitamin b 6 has been associated with decreasing the effectiveness of levodopa-carbidopa. I would recommend having your vitamin levels checked (there is a break down for all b) and see if you need it. Then your physician can better guide you. You can take B12 since there has not been a documented interaction and it is important for brain health. ...Read more
Discuss with your MD: Pregnancy cat. C. No teratogenic effects were observed in a study in mice receiving up to 20x the maximum recommended human dose but there are no adequate studies in pregnant women. In individual cases Levodopa crossed the human placental barrier, enters the fetus, and is metabolized. In a study of one nursing mother with pd, excretion of Levodopa in human breast milk was reported. Discuss with md. ...Read moreSee 1 more doctor answer
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