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Doctor insights on: How Does Tegretol Affect The Brain

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Dr. Mohamad Mikati
435 doctors shared insights

Carbamazepine (Definition)

This drug was once the breakthrough product to treat trigeminal neuralgia, and later various forms of epilepsy, and even psychiatric uses ...Read more


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I had a brain surgery last july and I used zyprexa (olanzapine) and tegretol daily until this january. I gained a lot of weight. Will I lose weight as im off meds?

I had a brain surgery last july and I used zyprexa (olanzapine) and tegretol daily until this january. I gained a lot of weight. Will I lose weight as im off meds?

You could: You could lose weight when off these medicines, especially if you increase your exercise and attend to a healthy food plan. Talk with your doctors about this; they'll likely have more personalized recommendations for you than we're able to provide without knowing you. Good luck to you. ...Read more

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In de novo epilepsy (age 67) MRI shows signs of slightly poor brain circulation. Is medication for circulation advised? The patient is now on TEGRETOL

In de novo epilepsy (age 67) MRI shows signs of slightly poor brain circulation. Is medication for circulation advised? The patient is now on TEGRETOL

Brain circulaton-sz: Why poor circulation? Ischemia (from clogged vessels)? Hypoplastic vessels (born with small vessels? Carotids? Did MRI show stroke? Do they have a fib? Was the seizure due to stroke/ TIA (rare)? Has the doctor discussed aspirin 81 mg or plavix (clopidogrel) or plental or fish oil (blood thinners so may cause bleeding)? F/u and discuss w/neurology http://www.ncbi.nlm.nih.gov/pubmed/11286042 ...Read more

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Geriatric epilepsy unknown etiology patient on TEGRETOL. Short memory loss and signs of poor brain circulation(MRI), drugs advised? Cavinton?

Geriatric epilepsy unknown etiology patient on TEGRETOL. Short memory loss and signs of poor brain circulation(MRI), drugs advised? Cavinton?

Cerebral blood flow: Carbamazepine is a good agent for seizures, but can be associated with cognitive side effects. If the issue is with blood flow in brain, additional details need to be provided. As for Vinpocetine (Cavinton) there is anecdotal evidence of improvement of blood flow, but there is less experience with that drug in regulated markets (eg US FDA) to comment on usage. ...Read more

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68 yr-old man, new-onset loss of left toes dorsiflexion, 51 years after Harvey Cushing's Osteoplastic Craniotomy for temporal lobe epilepsy.....?

68 yr-old man, new-onset loss of left toes dorsiflexion, 51 years after Harvey Cushing's Osteoplastic Craniotomy for temporal lobe epilepsy.....?

See ur NeuroSurgeon: New-onset loss of L foot dorsiflexion after craniotomy may be a complication of surgery, perhaps related to positioning. EMG/NCV (muscle & nerve testing) can localize site of nerve injury. Physical therapist can offer exercises to improve function as well as recommend ankle-foot orthotic to minimize risk of falling/tripping due to foot drop. Bottom line, chat w/your NeuroSurgeon then see FamilyDoc ...Read more

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How long would it take for a steady state concentration from 100mg of lamictal to 50 mg--keeping in mind i also take 600 mg of tegretol.

How long would it take for a steady state concentration from 100mg of lamictal to 50 mg--keeping in mind i also take 600 mg of tegretol.

Probably 2-3 days: Since the half-life of Lamictal is ordinarily about 33 hours (presuming normal kidney function) and the elimination half-life is decreased significantly by the presence of tegretol that speeds lamictal's metabolism, I think it should only take 2 to 3 days to reach steady state on 50 mg daily after having previously been on 100 mg daily. ...Read more

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Would 1 mg of ativan be about equal to 1 mg of klonopin (clonazepam). Keeping in mind the klonopin (clonazepam) is lowered by 600mg of tegretol by about 30%?

Longer duration: Klonopin (clonazepam) has a much longer effect than Ativan although I feel the tranquilizing effects are comparable. However different people react in differing ways to these 2 tranquilizers. ...Read more

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Does nocturnal temporal lobe epilepsy disappear? I have no seizures for 7 years. The seizures were 40 seconds long. I've always taken carbamazepine.

Does nocturnal temporal lobe epilepsy disappear? I have no seizures for 7 years.
The seizures were 40 seconds long. I've always taken carbamazepine.

Can: Most large studies of withdrawing seizure medicines were done at the 2 yr seizure-free mark. Evaluation by a neurologist can help evaluate the risk of tapering off. Eeg and MRI along with the history and exam help determine chances of success. If it's the genetic nocturnal tle, then recurrence would be likely off aeds. ...Read more

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Sometimes I forget my medications amlodopine (for hypertension) & carbamazepine (for temporal lobe epilepsy). Can I go without them like this?

Sometimes I forget my medications amlodopine (for hypertension) & carbamazepine (for temporal lobe epilepsy). Can I go without them like this?

Medications: Medicines are tested for effectiveness usually with one primary dosage methodology. If you want the outcome associated with the proof of effectiveness; you need to take the medication as it is approved and prescribed. If you don't take them as prescribed, your chances of the desired outcome are impaired. ...Read more

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Hv left temporal lobe epilepsy, on 150 mg lamictal x 2 times, tegretol 200 mg x 2 times. What are consequences of tegretol taken for over 30 yrs?

Hv left temporal lobe epilepsy, on 150 mg lamictal x 2 times, tegretol 200 mg x 2 times. What are consequences of tegretol taken for over 30 yrs?

Probably minor: Although tegretol rarely caused bone marrow suppression and liver abnormalities, the most likely long-term effects include low sodium, mild liver function abnormalities, elevation of cholesterol levels, and osteoporosis. ...Read more

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Hv left temporal lobe epilepsy, on 150 mg lamictal x 2 times, tegretol 200 mg x 2 times. What are consequences of tegretol taken for over 30 yrs?

Hv left temporal lobe epilepsy, on 150 mg lamictal x 2 times, tegretol 200 mg x 2 times. What are consequences of tegretol taken for over 30 yrs?

Some consequences: Long-term tegretol can affect sodium and liver functions, but can also raise cholesterol and contribute to osteoporosis. Unlikely, at this point, you will have bone marrow or liver damage. Might talk with your neurologist, as newer meds may be more convenient and safer. ...Read more

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Why can't I take pregnancy pills while taking tegretol?

Why can't I take pregnancy pills while taking tegretol?

You can: You can still take them, they just may not be as effective. The problem is that tegretol (carbamazepine) causes the hormones in birth control pills to be broken down by the body faster than normal, so you have lower levels of hormones in your blood to prevent pregnancy. If you do take bcps, you would probably need ones with higher amounts of hormones in them. Check with your ob/gyn. ...Read more

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Male 21years,7yearssigns of epilepsy displayed,12 years takes medication, Tegretol 200mg, 3 once a day.he didn't have improvement.change medicine?

Male 21years,7yearssigns of epilepsy displayed,12 years takes medication, Tegretol 200mg, 3 once a day.he didn't have improvement.change medicine?

Seizure management: It is advisable that the patient be switched over to other medications which are ssecond-generation drugs such as Keppra (levetiracetam) or Lamictal which are normally more effective and have less side effects. Switching her medication has to be done under medical supervision, please follow through with your neurologist while doing this. Anti-seizure medications have to be individualized. ...Read more

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Is tegretol a safe medication?

An old drug: Tegretol has been on the market for many years. It was one of the first antiseizure medications and is still prescribed pretty frequently. It is not without a slight risk for problems, however. Your doctor checks blood counts looking for signs of anemia or bone marrow problems, liver function tests to make sure the liver isn't affected, and a tegretol level to see how much is in your system. ...Read more

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What would be the peak time of tegretol?

What would be the peak time of tegretol?

Information below: The absorption of carbamazepine in man is relatively slow. When taken in a single oral dose, the carbamazepine tablets and chewable tablets yield peak plasma concentrations of unchanged carbamazepine within 4 to 24 hours. With respect to the quantity of carbamazepine absorbed, there is no clinically relevant difference between the various dosage forms. However, carbamazepine suspension is absorbed somewhat faster than the tablet; peak plasma levels are reached within 2 hours. Following b.i.d. dosage regimens, higher peak levels and lower trough levels are obtained with the suspension than with the tablets. Steady-state plasma levels are comparable for carbamazepine suspension given t.i.d. and carbamazepine tablets given b.i.d., when administered at the same total daily dose. ...Read more

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What is the definition or description of: carbamazepine?

Tegretol: This drug was once the breakthrough product to treat trigeminal neuralgia, and later various forms of epilepsy, and even psychiatric uses such as bipolar disorder. ...Read more

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Do all ssri's raise tegretol levels?

Yes: So the short answer is yes, but different SSRIs inhibit different parts of the bodies drug breakdown mechanism. Thus, some will increase the levels more than others. Also, everyone is a bit different. It is like that lexapro (escitalopram) has the least interactions in this way. ...Read more

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What are the side effects of carbamazepine?

Many: We see drowsiness, dizziness, nausea, even occas vomiting, blurry vision, general fatigue, and rarely, liver toxicity, bone marrow suppression with anemia, poor blood clotting, and even elevation of cholesterol. ...Read more

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I'm curious as to what are the side effects of tegretol?

Plenty: Include drowsiness, dizziness, upset stomach, nausea, toxicity to liver and/or bone marrow, with rare severe anemias, low sodium levels, elevated cholesterol, and of course, allergic reactions. This is a very old drug and used very rarely by most clinical neurologists. Far safer and effective drugs are currently available. ...Read more

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Why is tegretol sometimes used for headaches but not always?

Depends on diagnosis: Tegretol or Carbamazepine is a good option for face pains called neuralgias. Neuralgias can be very intense, sharp pains that can occur with something as little as water hitting the face. On the other hand, for primary headache disorders such as migraine, Carbamazepine would likely provide very little if any benefit. ...Read more

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What's tegretol and why would I get it for face pain?

What's tegretol and why would I get it for face pain?

Trigeminal Neuralgia: Tegretol an antiepileptic drug frequently used in the management of trigeminal neuralgia and other facial neuropathic pain. The Tegretol exerts its effect by preventing an influx of sodium ions into the cell. ...Read more

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What actually is the interaction of tegretol and lamictal?

Reduction Lamictal: The major interaction of these two drugs is lower Lamictal levels in serum. Other effects of combining these drugs include drowsiness, imbalance, and mental blunting. In general, any way you can be slow down mentally or physically can occur. ...Read more

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Can tegretol cause depression?

Can tegretol cause depression?

No: Not depression, but in some people can cause life threatening rush od the skin, called Stevens Johnson syndrom ...Read more

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Does tegretol lower the sperm count?

Does tegretol lower the sperm count?

Possibly: There have been rare reports of decreased or abnormal spermatogenesis with tegretol. ...Read more