Doctor insights on:
How Does Ribavirin Work
Sovaldi + ribavirin: Sovaldi (sofosbuvir) is a uridine nucleotide analog prodrug that is converted in liver to an active metabolite that inhibits the hcv ns5b rna-dependent RNA polymerase, which is essential for viral replication. The combination is fda-approved, forms an aasld/idsa recommended treatment arm for multiple genotypes, as well as for hcv/hiv coinfected patients, ; those with liver cancer pre-transplant. ...Read more
Hep c: Do you have to be on treatment now? By the end of this year ribaviran will most likely no longer be used to treat hep vc. Treatments will be more effective and shorter in duration. Ribaviran is not directly active against hep c like sofosbuvir and the other amazing drugs coming this year. ...Read more
I have beta-thalassemia and HCV. I was on interferon with ribavirin in 2008. It didn't work. Now I want to try Sovaldi. What are my chances it works?
Worth the try: It's looking really good. I hope you are able to get it. The politics of availability are bizarre -- I feel the drug company needs to see a fair profit that will allow more work, and that the people whose taxes paid for the basic research aren't denied a great medicine. Keep reading the blogs and find out the best way for you to get access to the real stuff at reasonable cost. ...Read moreSee 1 more doctor answer
Depends upon doses: All medicines have a threshold to cause signs of intoxication. If you know how much you did take ( number of pills or milligrams.) call the Poison Control Center 18002823171 in the USA to see if you should worry or go to the emergency room? If this happened recently in matter of few hours try to vomit them. ...Read more