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Doctor insights on: How Does Organophosphate Poisoning Cause Muscular Paralysis

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How does organophosphate poisoning cause muscular paralysis?

How does organophosphate poisoning cause muscular paralysis?

Inhibits AChE: Organophosphates inhibit acetocholinesterase, which is responsible for recycling actetocholine. This leads to muscle overstimulation and rigid paralysis (amongst other things). ...Read more

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Palsy (Definition)

...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more


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Hi doctors, can you tell me what is organophosphate poisoning?

Hi doctors, can you tell me what is organophosphate poisoning?

It can be fatal: Organophosphates are found in insecticides, herbicides, and nerve agents. They block an enzyme that breaks down acetylcholine (ACh). As a result, ACh accumulation can cause anxiety, headache, convulsions, respiratory failure, tremor, general weakness, and potentially coma. Patients with symptoms and an exposure history should go to the closest ER. Ref: www.ncbi.nlm.nih.gov/pmc/articles/PMC2493390 ...Read more

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Can you get organophosphate poisoning from morning glory seeds?

Can you get organophosphate poisoning from morning glory seeds?

No: Not unless they were sprayed with an organophosphate, which are mostly in insecticides. The dangerous chemicals in morning glory seeds are atropine-like chemicals (alkaloids) which can cause visual disturbances, tachycardia, panic-like states and sometimes hallucinations and convulsions. In high doses, they can be lethal. ...Read more

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What happens when you get organophosphate poisoning?

Parasympathetic : Parasympathetic over drive: excess salivation, lung secretions and shortness of breath, incontinence of urine and stool, and coma in severe cases. ...Read more

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How can organophosphate poisoning be treated?

Decontaminate: Atropine injection as soon as possible. Followed by supportive care. Person might need ventilator support for breathing until effects of OP provisioning wears off. ...Read more

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What are the symptoms of organophosphate poisoning?

List of symptoms...: Muscle weakness, fatigue, muscle cramps, muscle twitching, and paralysis can be seen. Higher blood pressure, lower blood sugar, anxiety, headache, convulsions, and slowed breathing can happen. Visual changes, chest tightness, wheezing from bronchoconstriction, more bronchial secretions, increased salivation, lacrimation, sweating, vomiting, diarrhea, and urination can occur. ...Read more

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What signs would you expect to observe if organophosphate poisoning?

Water everywhere: Ops prevent the breakdown of acetylcholine. Excess of this leads to excess stimulation of the cholinergic nervous system. This is manifest by salivation, lacrimation (tears), sweating, urination, diarrhea, nausea and vomiting. The most concerning symptoms are the "killer b's" - bronchorrhea (fluid in lungs), bronchospasm (spasm of air passages) and bradycardia (slow heart rate) which can kill. ...Read more

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How to describe poisoning by organophosphates and pesticides?

How to describe poisoning by organophosphates and pesticides?

Typical scenario: This class of chemicals affects acetylcholine and can result in diffuse weakness, and difficulty breathing if excess exposure does occur, besides additional systemic and GI symptoms. This could well develop rapidly into a medical emergency. ...Read more

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Is there a condition that can cause occasional facial paralysis?

Yes: There are a few causes of recurrent facial paralysis. Melkersson-rosenthal syndrome, certain viral infections, etc can cause this. ...Read more

Dr. Wm. Marcus Spurlock
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Poisoning (Definition)

Toxic ingestion (also called "poisoning") is a condition in which a person has eaten or drank a substance that causes ill symptoms or damage to his body. Taking an overdose of a medicine, taking any dose of a poison, drinking too much vodka, or accidentally drinking antifreeze . . . are all ...Read more


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Paralysis (Definition)

A paralyzed limb cannot be voluntarily moved, and the term reflects leg involvement, paraplegia, full body, quadriplegia, and less than full, tetraplegia. Causes can be many, including stroke, trauma, ...Read more