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Doctor insights on: How Does Letrozole Work

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How does letrozole work?

How does letrozole work?

Eliminating estrogen: Letrozole like anastrazole and Exemestane is an aromatase inhibitor. In postmenopausal pts, the ovaries no longer produce estrogen but the body creates low levels of estrogen via the enzyme aromatase. The ais block this enzyme thus eliminating any estrogen. In premenopausal pts, this actually causes a feedback that stimulates the ovaries to make more estrogen thus it can't be used to treat er+. ...Read more

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Dr. Hirenkumar Italia
74 doctors shared insights

Letrozole (Definition)

Letrozole is a commonly used medicine for the prevention/treatment of certain types of breast cancer. It is a safe medicine. It prevents the conversion of male to female hormones. It is also commonly used now for fertility treatment. It can help ovulation and can help a woman make an extra egg sometimes. It is often used instead of Clomid (clomiphene) for fertility treatment ...Read more


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Can you tell me if letrozole and trigger works well?

If appropriate: If used in young women to treat ovulatory infertility, and if timed correctly, this can be successful treatment. For older women (say >38 y.o.), for anything besides ovulatory infertility, and if not timed well it is unlikely to be successful. Good wishes. ...Read more

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21 day progesterone level 6.2. Will femara (letrozole) raise that level? If so how fast?I have one child who is 5. Just wondering if femara (letrozole) works and how fast

21 day progesterone level 6.2. Will femara (letrozole) raise that level? If so how fast?I have one child who is 5. Just wondering if femara (letrozole) works and how fast

Works and fast: B"sd the largest study: "The ovulation rate was superior with letrozole (61.7%) than with Clomid (clomiphene) (48.3%)" that means that on average you will ovulate more than 1/2 of the cylces you take it on. "Letrozole is a medication that is metabolized rapidly in the body. It is not thought to have significant levels in the blood or tissues for a prolonged period of time" That is each cycle stands alone. ...Read more

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2 rounds of letrozole in one cycle. Is that normal? If the 1st round didn't work why a 2nd? Would the next step be injections? I have pcos

Unclear: It is unclear exactly what is going on here in this question. My assumption is that you are taking Letrozole in order to assist with ovulation. I would clarify the plan with the prescribing physician who knows you best. If you did not ovulate then there is no “cycle” so Letrozole could be restarted. ...Read more

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My doctor prescribed letrozole(7.5mg per day) from CD 2-7 for my infertility. how it works for conceive?

Stimulates ovulation: Letrozole blocks the production of estrogen. The brain responds by secreting FSH that stimulates the ovary to have an egg follicle grow to produce more estrogen. Hopefully, the egg follicle will mature and ovulate to improve your chance to get pregnant. ...Read more

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What is letrozole for?

Breast cancer: It is 'for' management of breast cancers in women, although it's often prescribed for ovulatory infertility. ...Read more

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Can letrozole cure gyno?

I don't know: I don't know what 'gyno' is, so I cant answer the question. Letrozole is a type of drug called an antiestrogen and is used to treat breast cancer. ...Read more

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Where can I get letrozole?

From a doctor: Letrozole is a prescription medicine, so in most countries a doctor has to write a prescription before you can obtain it from a chemist shop. ...Read more

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What is letrozole good for treating?

What is letrozole good for treating?

ER+ Breast CA: Letrozole belongs to a class of drugs called aromatase inhibitors. These drugs are very effective agents for treating hormone-sensitive (estrogen receptor +) breast cancers in post-menopausal women. ...Read more

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