Doctor insights on:
How Does Isosorbide Dinitrate Or Mononitrate Help Prevent Angina Attacks
Supply and demand: Angina is caused by heart muscle not getting enough blood to meet its needs, think supply vs demand. By relaxing smooth muscle in the walls of coronary arteries, nitrates increase blood flow. They also dilate the body's veins, so less blood returns to the heart, and the heart walls are less stretched outwards. This reduces tension on the heart wall muscle, and hence demand for oxygen/blood. ...Read moreSee 1 more doctor answer
Angina is chest pain that is caused by poor blood flow to the heart muscle. Angina is not an actual disease, but rather a symptom of an existing heart problem. Most commonly, this underlying problem is due to an obstruction of the coronary blood vessels that surround the heart. There are different types of angina including stable angina, unstable ...Read more
A-HEFT Trial: A large trial looked at the combination of hydralazien and Isordil (isosorbide dinitrate) with african american patients and showed a benefit of improving heart failure status, on top of standard medical therapy. It is thought to be believed due to lack of Nitric Oxide delivery to endothelium in african americans, that is improved by this therapy. Blood pressure tends to be higher in the first place, which improves. ...Read more
Dilates vessels: It dilates blood vessels and lowers blood pressure. Burning under the tongue and headache are normal for new users. Esophageal smooth muscle is also affected so relief of pain is not specific for heart disease. Effects occur 2-3 minutes after a sublingual dose and last 20-30 minutes. Gi pain often requires 2 or 3 nitros for full relief. ...Read more
Roxonal: Roxonal is morphine. Morphine in sufficient dose is effective for most pain. We do not blithely prescribe morphine for angina unless all other forms of therapy are exhausted and inadequately effective. Nitro spray works effectively and rapidly for most anginal episodes. We generally use multiple drugs when treating patients with coronary artery disease and when appropriate stents or surgery. ...Read more
For chest pain/possible coronary artery vasospasms/Prinzmetal angina... How long does it take for Diltiazem to ease the pain?
Depends: Diltiazem functions to relax the walls of the heart blood vessels. If you take the extended release tablet, it takes about 10 to 14 hours for the drug levels to peak in the blood. Of course, it would take less time for the regular tablets. It is iportnant to take the dose at the same time daily and not miss dose so that the blood levels can get to therapeutic levels and thus control your pain. ...Read more
Prescribed metoprolol ER (beta blocker)? Only 12.5 mg daily. Is this safe? Can this cause bradycardia or cardiac arrest/heart attack or anything?
Whats better for Prinzmetals Angina, Verapamil or Diltiazem? How much better? Whats correlation w migraine? Does treating one resolve other?
Do beta blockers such as toprol (metoprolol) help to prevent atrial and ventricular fibrillation?
Yes to an extent: More beneficial to prevent af than vf! ...Read more
80 mg propranolol ER vs propranolol. Which is best for long term BP control, anxiaty, and angina.
Can you tell me how fast does nitroglycerin act when used to treat a myocardial infarction, i.E. When given in tablet form?
What can I do to prevent nightmares from taking lopressor (metoprolol tartrate) beta blocker for my heart?
Coping wi/ nightmare: Ask doctor about alternative med. Nightmares arise from meds & other reasons. Develop management skills: learn relaxation, breathing, & visual imagery; practice daily & nightly. This will help heart, bp, mind, general well-being, reduce stress & incidence of nightmares. Use calming skills when nightmares occur & train your brain by rewriting nightmare to outcome you desire. Sweet dreams. ...Read more
Isordil (isosorbide dinitrate): How do you know you are tolerant to the drug? ...Read more
How quickly does nitroglycerin act when used to treat a myocardial infarction, i.E. When given in tablet form?
Almost immediately : Nitroglycerin given under the tongue is very rapidly absorbed into the blood stream. It can begin to work within 30 - 60 seconds to relieve chest pain and increase blood flow to the heart. Taking Nitroglycerin during a suspected heart attack should not delay calling 911 however. ...Read moreSee 1 more doctor answer
Can beta blockers such as propranolol or toprol (metoprolol) help prevent ventricular fibrillation in susceptible individuals?
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