Doctor insights on:
How Does Gabapentin Work For Nerve Pain
Still unknown: We used to think that amitriptyline acted on the brain at the level of the thalamus or other pain interpretive centers but recent evidence points to a peripheral action site blocking C-type pain fibers- specifically, nicotinic acetylcholine receptors carrying neuropathic pain. More cool (and PRACTICAL) stuff if you want to talk about it: www.healthtap.com/drsaghafi ...Read moreSee 1 more doctor answer
The brain and spinal cord communicates with what is occurring in the internal organs and limbs by nerve fibers where are like electrical wires with insulation (myelin) and the "copper" (axon). Within brain and spinal cord these nerves connect to other nerves via synapses on both axons and dendrites. A nerve can carry information regarding sensations, and ...Read more
It can help: However conventional wisdom is that if you haven't gotten enough relief with one Medrol (methylprednisolone) dose pack, unlikely its better to give more. In fact new research is showing that your risk of fracture increases almost 400% after one oral dosepack of steroids. You are better off getting an epidural steroid injection instead. Risk still exists but way less compared to oral steroids. ...Read moreSee 1 more doctor answer
Varies: Some patients report improvement soon after they take it. Under dosing is not uncommon. Its a generally safe medication with few drug interactions and works better at higher dosage, side effects permitting. ...Read more
Blocks glutamate: The exact mechanism is not fully understood. Neurontin (gabapentin) may work by binding to certain sites on nerve cells in order to block the release of glutamate. Glutamate in turn causes nerve cells to be abnormally excited and therefore accentuate pain. Does that help? ...Read more
Non-medical evidence: Recent studies of chronic pain management suggest that a combination of psychological, pharmacological and physical therapies, tailored to the needs of the individual patient, may be the best approach to mange neuropathic pain. Pharmacological choices are: amitriptyline, duloxetine, Neurontin or Lyrica (pregabalin) as initial treatment for neuropathic pain, but not B12. ...Read more
4-6 weeks: Initially the symptoms last 4-6 weeks and if your body heals like it supposed to then pain relief starts. However disc herniations which are the cause of majority of sciatica symptoms last for 6-9 months and therefore people can have pain during that time as well. If not better after 6 weeks see a spine specialist to evaluate this further. ...Read moreSee 1 more doctor answer
Has anyone taken lyrica (pregabalin) for chronic back pain? How well does it work?
What would you compare it to percocet, vicodin, tramadol
Common Rx.: Pregabalin is sometimes prescribed for chronic pain. Seems to have a better benefit from pain that is of nerve origin. Difficult to predict if you will benefit as the cause of your pain is not clear from the description.. Pregabalin is nothing like the other opioids you mention. ...Read more
How long does it usually take elavil (amitriptyline) to work for chronic pain and depression together?
Horse racing: Some say 'yes' and some say 'no'. So, it's like many, many medications. Ask about potential bad effects and how hard it is to stop if you don't like it. Then, prepared, give it a try if you want and see if you're pro or con. Consider alternatives to pills too. Accupuncture, massage, ortho, yoga, etc. Try things in a sequence that lets you easily move on to the next candidate w/out w/drawal. ...Read more
How long does Neurontin (gabapentin) take to take affect pain wise ? Taking for neuropathic symptoms.
Quickly: Gabapentin (brand name neurontin) will be effective in about an hour after taking the first dose and lasts about 6-7 hours. If you have constant pain, then you will need to take it three or four times a day. The dose that patients need varies a lot, so if the medication does not help after several doses, call your physician to see about adjusting the dose. ...Read moreSee 1 more doctor answer
Been prescribed amitriptyline for nerve related pain. Prickly burning sensations in upper back and legs. How long does this drug take to work approx?
Outcome: Oral or intravenous steroids may have a lag period of about 48 hrs prior to initial benefit, and the effect may build over a few more days, but if you have not noted at least some minor benefit after 5-7 days, unlikely this will improve beyond that point, and you might do better with an epidural steroid injection. ...Read moreSee 1 more doctor answer
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