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Doctor insights on: How Does Dcis Become Harmfully Invasive

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How does dcis become harmfully invasive?

How does dcis become harmfully invasive?

Unknown: If we knew the answer to this question, women with dcis would not all need surgery! about 50% of dcis (ductal carcinoma in situ), if left untreated, will go on to become invasive cancer. Certain genes in the dcis cells get "turned on", making them invasive, but we don't know what makes this switch happen. ...Read more

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Dr. Milton Alvis Jr
55 doctors shared insights

Intraductal Carcinoma (Definition)

Intraductal carcinoma is a noninvasive condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other ...Read more


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Why does dcis become invasive?

Why does dcis become invasive?

Unknown: If we knew the answer to this question, women with dcis would not all need surgery! about 50% of dcis (ductal carcinoma in situ), if left untreated, will go on to become invasive cancer. Certain genes in the dcis cells get "turned on", making them invasive, but we don't know what makes this switch happen. ...Read more

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Why is it that some women have to have mastectomy for dcis if it's a non invasive cancer?

You are right: Ordinarily, mastectomy is not necessary for precisely the reasons you have mentioned. So the standard treatment is excision of the dcis followed by radiotherapy to the affected breast. The only exception may be, if there are multiple dcis lesions in one breast....So unless you have this type of dcis, you do not need a mastectomy. ...Read more

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MRI biopsy was done and showed DCIS. Histopathology showed invasive ductal with 2.5 mm microinvasion (grade 2). ER-PR negative, HER +ve (+3). My ques?

MRI biopsy was done and showed DCIS. Histopathology showed invasive ductal  with 2.5 mm microinvasion (grade 2). ER-PR negative, HER +ve (+3). My ques?

I'm not sure: of the question. It is not unusual for an image-guided needle biopsy DCIS to be 'upgraded' to an invasive cancer at surgery. The needle biopsy randomly samples small areas of the lesion, whereas following surgery the pathologist has the whole mass to work with. It is relatively common to have elements of DCIS and invasive components existing in different parts of the same tumor. ...Read more

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Does dcis usually turn into invasive breast cancer?

Does dcis usually turn into invasive breast cancer?

If left alone: Current thought is that if left untreated, dcis will develop into invasive breast cancer. ...Read more

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I had 1mm of invasive dcis and had lumpectomy, mastectomy and 13 nodes removed, tamoxifen. High estrodial, then bi.Ooph & arimidex (anastrozole) is it excessive?

I had 1mm of invasive dcis  and had lumpectomy, mastectomy and 13 nodes removed, tamoxifen. High estrodial, then bi.Ooph & arimidex (anastrozole) is it excessive?

NO : Lots of information missing , the results of the tests. If I have to guess had initial lumpectomy , later mastectomy was done most likely due to recurrence , ovaries removed to control skeletal metastasis, if it is true it is usual correct pathway to control aggressive tumor in 53 yr old , not true provide additional info, speak to oncologist , good luck if all neg , seek ii nd opinion. ...Read more

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Dx w/ invasive ductal carcinoma er + & pr +. Grade 2. Waiting on DCIS. Meeting w/ two oncologists & surgeon. What do I ask??

Dx w/ invasive ductal carcinoma er + & pr +. Grade 2.  Waiting on DCIS.  Meeting w/ two oncologists & surgeon. What do I ask??

Depends tumor size: If tumor small and was non palpable but only defined on mammogram, if lesion with intraductal components smaller than 1 cm, and sentinel node bx neg. I would wait to hear about margins. Margins that are adequate about 1cm around lesion suggests lesion in high 90% cure without RT. If larger lesion then possibly RT and tamoxifen. ...Read more

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What does extensive low grade DCIS, No invasive malignancy is presented means in histopathology report for left breast lump with Benign fibrocycstic?

What does extensive low grade DCIS, No invasive malignancy is presented means in histopathology report for left breast lump with Benign fibrocycstic?

It means precancer: DCIS is a common problem in women. It is the beginning of cell changes which appear cancerous yet they are still not fully converted into cancer. Invasion by cancer cells is required in order to label them as cancerous. There is some risk that DCIS can convert into Invasive Breast Cancer. So it is a good idea to remove this abnormality/lump compeltely ...Read more

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Breast cancer after miscarriage? 2.5mth healthy pregnancy-miscarriage.2 wks later. 2.5.cm lump-biopsy-invasive dcis.confused info from all dr's

Breast cancer after miscarriage? 2.5mth healthy pregnancy-miscarriage.2 wks later. 2.5.cm lump-biopsy-invasive dcis.confused info from all dr's

I am assuming: the question is whether the cancer had caused, or indirectly affected the viability of, the embryo/fetus. I do not think any Doctor or scientist can tell you for sure. There is a direct correlation between cancer and blood clotting ability, i.e. cancer increases the risk that venous blood clots will occur. And there is also a direct correlation between increased clotting and miscarriages. ...Read more

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How fast does dcis spread?

Quite slowly: It is difficult to define. But it does not spread all that fast. You have a few months before you need to worry about that. ...Read more