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Doctor insights on: How Does Dcis Become Harmfully Invasive

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How does dcis become harmfully invasive?

How does dcis become harmfully invasive?

Unknown: If we knew the answer to this question, women with dcis would not all need surgery! about 50% of dcis (ductal carcinoma in situ), if left untreated, will go on to become invasive cancer. Certain genes in the dcis cells get "turned on", making them invasive, but we don't know what makes this switch happen. ...Read more

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Dr. Adam Lewis
56 doctors shared insights

Intraductal Carcinoma (Definition)

Intraductal carcinoma is a noninvasive condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other ...Read more


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Why does dcis become invasive?

Why does dcis become invasive?

Unknown: If we knew the answer to this question, women with dcis would not all need surgery! about 50% of dcis (ductal carcinoma in situ), if left untreated, will go on to become invasive cancer. Certain genes in the dcis cells get "turned on", making them invasive, but we don't know what makes this switch happen. ...Read more

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How much faster does non seminoma tc grow than seminoma tc? How much will they untreated grow in a year?

How much faster does non seminoma tc grow than seminoma tc? How much will they untreated grow in a year?

Testicular cancer: Non seminoma tc grows faster than seminoma in most circumstances, there is no way to tell with certainty how fast any of these tumors will grow in a year if left untreated. The real question here is why wait, if you have one, no matter what kind, get treatment asap. ...Read more

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Young male with stage 2 lung cancer and does not want treament how long to live?

Young male with stage 2 lung cancer and does not want treament how long to live?

Stage II mostly : Involves hilar nodes, and a lesion 2 cm or less. If that fits, you've llikely had surgery. Lung cancer kills by local recurrence but more distant metastases: brain, liver, bones. These do not all happen at once. Fewer than 50% survive 5 years with treatment, and as symptoms develop, you may change your mind. ...Read more

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How long does oral hpv take to become cancerous generally ?

How long does oral hpv take to become cancerous generally ?

Many years, rare: The vast majority of HPV infections, even those with "high risk" (cancer causing) HPV types, ever become cancerous. Of the 100+ types of HPV, only one, HPV16, causes oral cancer. Of these, probably less than one in a thousand oral HPV infections lead to cancer. When it happens, it can be anywhere from 1 to 30 years later. ...Read more

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How long does it generally take for uterine cancer to progress to stage 4?

How long does it generally take for uterine cancer to progress to stage 4?

Tumor stage: Declares extent by t, n and m characteristics at the start. Many confuse "stage" as a calendar and a step-wise progression that can be predictably timed...Thus your question. The uterus is divided between cervix and corpus or body. The body usually refers to the endometrial lining, and the stage by invasion into the muscle. Stage IV almost always means distant disease. Some start there. ...Read more

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How long does it take for stage1 colon cancer to develop into stage 4?

How long does it take for stage1 colon cancer to develop into stage 4?

Tough question: The evolution from polyp to cancer usually takes more than ten years. From state i to stage four probably takes several years, also, but can vary depending on how rapidly the cancer grows and spreads. ...Read more

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How fast does invasive ductal carcinoma develop metastasis?

How fast does invasive ductal carcinoma develop metastasis?

Can be quick, but: Could be years or never. You do not mention: size; stage, nodes + or -, age, receptor status (er, pr, her-2-neu). Breast cancer treatment can effect chance of relapse. I find the questions about speed odd...The true answer is we do not know in an individual what will happen, and rely on group statistics to frame what we tell patients. I emphasize, that individual may not behave like a group. ...Read more

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Transgender. How would removal of testicles significantly before SRS afffect vagioplasty outcome? If difference in depth, how significant?

Transgender. How would removal of testicles significantly before SRS afffect vagioplasty outcome? If difference in depth, how significant?

Orchiectomy first...: Some transgender women have orchiectomy (removal of the testicles) because they cannot tolerate the effects of testosterone blockers like spironolactone. Testicles usually shrink anyway under the influence of estrogen; after their removal the scrotum "flattens." Talk to your surgeon, and be sure to be conscientious with your vaginal dilation after surgery. LGromkoMD ...Read more

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How long does it take for squamous esophageal cancers to develop to tumor size 5 cm?

How long does it take for squamous esophageal cancers to develop to tumor size 5 cm?

Not easy: To answer. Esophagus cancer can develop over years or months. Prior strictures, chronic irritations and alcohol and tobacco are associated in squamous cancer, and reflux closer linked to reflux and barrett's, but the time course and precursors are not predicable. ...Read more

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If IRE ( nano knife )is done for colon cancer mets, can person get long term remission ?

If IRE ( nano knife )is done for colon cancer mets, can person get long term remission ?

Palliation possible: IRE ( irreversibleelectroportation ) a minimally invasive procedure , soft tissue tumor cells are killed by electrical thermal energy , sparing close by vital structures like blood vessels Fair remission is possible by reducing tumor load on host , preventing pressure on vital organs etc ...Read more

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How long can a person with hodgkin's keep living normally untreated before they become really sick? Can they be well 3 years later without treatment?

Wow: Good question. Patients with certain kinds of non-hodkin's can do well for over a decade with no therapy but i'm not sure the same is true for hd. Why would someone not want to be treated for a very curable illness? ...Read more

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How long do people usually live with untreated breast cancer?

How long do people usually live with untreated breast cancer?

Variable: This is highly dependent on the cancer type and stage of presentation. Some aggressive forms of cancer may take over vital organs within months; other breast cancers may rarely spread to other organs and may be indolent for years and years. What remains true is that there is no benefit of "watchful waiting" when it comes to breast cancer: all else being equal, early diagnosis can save lives. ...Read more

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How long can a persn live with invasive bladder cancer without treatment (t1g3)?

How long can a persn live with invasive bladder cancer without treatment (t1g3)?

Bladder ca: Nobody can predict. Grade 3 has a higher chance of recurrence and progressive. Treatment is highly recommended but nodoby can accurately tell you a time line in this areas. It could be months to years before someone could die depending on the cancer. ...Read more

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How often does dysplastic Nevus turn into melanoma? What percent will actually become malignant? Thanks

How often does dysplastic Nevus turn into melanoma?  What percent will actually become malignant?  Thanks

Depends on grade: Excisional biopsy of dysplastic nevi with moderate-to-severe and/or severe dysplasia can be of benefit because of the association and potential conversion to malignant melanoma. It is suggested that excision of biopsy-diagnosed DN with mild or moderate dysplasia has less of a benefit with minimal evidence of conversion to invasive melanoma. ...Read more

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With metastatic brain cancer, how do you predict one's remaining life expectancy?

With metastatic brain cancer, how do you predict one's remaining life expectancy?

See below: Both irradiation and an operation to take out single metastasis will prologn the life for mohts to a year not only that the life will be better. ...Read more

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How long does a person live with endometrial cancer with metastasis to the lymph node? Can it still be cured? Chances ?On chemotheraphy and radiation

How long does a person live with endometrial cancer with metastasis to the lymph node? Can it still be cured? Chances ?On chemotheraphy and radiation

Not hopeless: Common endometrial adenocarcinoma that's made it to a lymph node is stage iiic1 or higher, but the odds of five year survival are given at 15% or better. Don't give up. ...Read more

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How long does it take for a bladder to heal is biopsy if performed where there has been external beam radiation damage? ( treated for prostate cancer)

How long does it take for a bladder to heal is biopsy if performed where there has been external beam radiation damage? ( treated for prostate cancer)

It Depends: The rate and extent of healing depend on the amount of radiation received, the time since radiation, the size of the wound, other medical problems a person may have and other factors. Generally, i would expect that a bladder biopsy after prostate cancer radiation would heal in a a week or two, but there is a small possibility of getting a long-lasting wound. ...Read more

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How long will you.Survive with triple negative breast cancer if untreated?

How long will you.Survive with triple negative breast cancer if untreated?

Don't find out: It is impossible to answer this question without knowing more, particularly what stage the cancer is at. But don't find out. Even triple negative cancer, if caught at an early stage, can be curable. Surgery, radiation and chemotherapy sound terrible and scary but are more tolerable than people think and we have become much better at managing side effects. Talk with women who have been through it. ...Read more

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