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Doctor insights on: How Does Clopidogrel Inhibit Platelet Function

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Does clopidogrel reduces the platelet count?

Does clopidogrel reduces the platelet count?

Not typically: It is not the mechanism of action. Ttp is among rare but potentially serious adverse reactions which is associated with drop in platelet count. ...Read more

Dr. Mathew Chengot
343 doctors shared insights

Plavix (Definition)

Plavix is a platelet inhibitor is a kind of anti-coagulation drug ...Read more


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What is differences between Antiphospholipid Syndrome and Sticky Platelet Syndrome? Just found out that I have both of them. On Plavix (clopidogrel) 75mg.

What is differences between Antiphospholipid Syndrome and Sticky Platelet Syndrome? Just found out that I have both of them. On Plavix (clopidogrel) 75mg.

Autoimmune/genetic: Sticky platelet syndrome is an inherited condition affected platelet aggregation. Anti phospholipid syndrome is an autoimmune disorder that can involve multiple different points in the coagulation process, not just platelets. Both tend to be treated with aspirin and sometimes some additional anticoagulant. ...Read more

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How often are glycoprotein inhibitors used prior to surgery for patients needing to be off plavix (clopidogrel) prior to surgery? Is it a good option? I had 2 de stents oct 2012. Need to remove tumor in abdomen.

How often are glycoprotein inhibitors used prior to surgery for patients needing to be off plavix (clopidogrel) prior to surgery? Is it a good option? I had 2 de stents oct 2012. Need to remove tumor in abdomen.

GPIIb/IIIa use: Gpiib/iiia inhibitors are indicated for unstable angina, heart attack and stent placement and not for all different kind of surgery. Having abdomen tumor make you high risk of bleeding. Need physician supervision to monitor platelets, pt, inr, act, aptt if it is used. You already have de stents. May want to discuss about Lovenox (enoxaparin) with short half life. Your doctor has to observe you closely. Good luck. ...Read more

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Can a platelet function disorder be a sign of vascular Ehlers Danlos?

Can a platelet function disorder be a sign of vascular Ehlers Danlos?

Usually not: In children with EDS, excessive bruising is often the presenting complaint to the pediatrician. Hematological studies including evaluation of clotting factors, platelet aggregation and bleeding time are usually normal in patients with EDS, Capillary fragility is usually cause of bruising in EDS.Generalized vascular fragility largely dominates the clinical picture. ...Read more

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Why is it that aspirin can prevent blood clots in arteries but not in veins? If it inhibits platelet function, why does it not do that everywhere?

Why is it that aspirin can prevent blood clots in arteries but not in veins? If it inhibits platelet function, why does it not do that everywhere?

It does: It does inhibit platelet function. It does inhibit clot formation in veins. Its just that venous clots aren't quite as serious an issue. We worry about clots in the arteries to your heart that can lead to heart attack or an artery to your extremity leading to cold leg or arm. People do get clots in their veins, they are called DVTs but they usually aren't fatal. ...Read more

Dr. Alan Ali Dr. Ali
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I have a bleeding disorder (platelet function defect), and I want a tattoo, is it safe?

Dr. Alan Ali Dr. Ali
2 doctors agreed:
I have a bleeding disorder (platelet function defect), and I want a tattoo, is it safe?

Tattoo: Safe under experienced tattooer, as long as no infection occurs (clean instrument, gentle hands). ...Read more

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Platelet function test: collagen epinephrine normal, but ADP prolonged by 25 sec. Possible causes? Have normal CBC, PT, aPTT, CRP, d-dimer, comp met.

Platelet function test: collagen epinephrine normal, but ADP prolonged by 25 sec. Possible causes? Have normal CBC, PT, aPTT, CRP, d-dimer, comp met.

Aspirin exposure: This pattern of results could be from ingesting aspirin in some way. Aspirin (acetylsalicylic acid) is found in many things these days, including migraine meds, suppositories, fever/cough/cold relievers, & other OTC medications. Also, salicylate (salicylic acid), a prescription med for joint pain possible. Lastly, Plavix (clopidogrel) & other newer prescription meds aren't excluded. Happy hunting 4 u & ur doc! ...Read more

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Please help! what is the difference between anti-platelets (plavix) and anti-thrombins?

Clotting: Clotting involves both cells that stick together and proteins that form a mesh. Anti-platelets work on the cells. Anti-thrombins work on the proteins. ...Read more

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Can Lexapro (escitalopram) be taken with plavix, 81mg asprin and 5 mg lisiniprol? I read it may incr. Ssri levels and anti platelet effects. What does that mean?

Can Lexapro (escitalopram) be taken with plavix, 81mg asprin and 5 mg lisiniprol? I read it may incr. Ssri levels and anti platelet effects. What does that mean?

Use with caution: As with all meds, use is determined by balancing benefits against potential adverse rxns. You're right on both counts: there is incr. Ssri levels and more anti-platelet effect. Beware of abn. Bleeding/bruising. Hyperreflexia and tremor can occur. Rarely, more serious effects like anxiety, agitation, tachycardia and altered thinking (serotonin sydrome). ...Read more

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Pernicious Anemia :B12 injections every 2 mths would taking 15 mg Lansoprazole every day for two years with Plavix to protect the stomach from side effects from Anti-platelet .Could this deplete B12 and magnesium and cause neurological symptoms?

No: And if you want another way to get extra B12, you can get B12 pills OTC. Take 1000 unit pill once a day. Will yield same result as injections. Do you really need Lansoprazole???? Are you sure? Why taking Plavix for 2 years? Usually Plavix is used for 6 to 12 months after a stent or CABG. You should be taking an uncoated baby aspirin once a day. ...Read more

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Why we usually give aspirin daily in stroke and ihd although it irreversible inhibitor of platelet agreggation and platelet life 10 days?

Why we usually give aspirin daily in stroke and ihd although it irreversible inhibitor of platelet agreggation and platelet life 10 days?

New platelets: Your bone marrow generates new platelets every day, and these will be untreated and fully active. Daily asa makes sure the platelets are adequately treated. ...Read more

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Low platelet count & Splenomegaly .ADP Aggr is mild impaired, Platelet Morph Aggr is OCC Enlarged suggestive of P2Y12-Inhibitor Effect What it means?

Low platelet count & Splenomegaly .ADP  Aggr is mild impaired, Platelet Morph Aggr is OCC Enlarged suggestive of P2Y12-Inhibitor Effect
What it means?

Please decipher: would you kindly focus on one aspect and avoid abbreviations so we can be able to help you better or direct you to the right speciality, thanks ...Read more

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Why can't plavix (clopidogrel) be injected?

Liver activation: Plavix (clopidogrel) is a pro-drug which is inactive. upon oral administration, Plavix (clopidogrel) is activated in the liver to become the active drug, injection of Plavix (clopidogrel) will bypass the liver activation of phase of the drug. clinical studies of Plavix (clopidogrel) were done with oral administration, there are however other medications used in the hospital setting that are injectable, however used in the setting of heart attacks ...Read more

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My mom ran out of plavix (clopidogrel) and hasn't taken it for 4 days. Her neurologist told her to take 4 at one time to make up for it is this safe?

My mom ran out of plavix (clopidogrel) and hasn't taken it for 4 days. Her neurologist told her to take 4 at one time to make up for it   is this safe?

Unknown: The effects of Plavix (clopidogrel) on blood clotting are present for up to a week. The usual recommendation is to resume the usual Plavix (clopidogrel) dose if dosing has been interrupted for any reason such as surgery or unavailability of the medication. Additional doses are most likely not more beneficial. ...Read more

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