Doctor insights on:
How Does Clopidogrel Inhibit Platelet Function
What is differences between Antiphospholipid Syndrome and Sticky Platelet Syndrome? Just found out that I have both of them. On Plavix (clopidogrel) 75mg.
Autoimmune/genetic: Sticky platelet syndrome is an inherited condition affected platelet aggregation. Anti phospholipid syndrome is an autoimmune disorder that can involve multiple different points in the coagulation process, not just platelets. Both tend to be treated with aspirin and sometimes some additional anticoagulant. ...Read more
Whether New oral anticoagulant drugs (pradaxa 150 2x/day) may be combined with anti-platelet drugs (Plavix (clopidogrel) 75 mg/day)?? i'm in Af also CAD??
Yes: be carful about bleeding because there is no antidote for these new agents. ...Read more
Do Antiphospholipid Syndrome and Sticky Platelet Syndrome inherited? How can I get both at once? Is it curable? I'm taking Plavix (clopidogrel) and Xarelto for DVT.
A question for cardiologists...Did we give gp2b/3a inhibitors (abciximab...) with aspirin and clopidogrel during pci or only aspirin and clopidogrel?
How often are glycoprotein inhibitors used prior to surgery for patients needing to be off plavix (clopidogrel) prior to surgery? Is it a good option? I had 2 de stents oct 2012. Need to remove tumor in abdomen.
GPIIb/IIIa use: Gpiib/iiia inhibitors are indicated for unstable angina, heart attack and stent placement and not for all different kind of surgery. Having abdomen tumor make you high risk of bleeding. Need physician supervision to monitor platelets, pt, inr, act, aptt if it is used. You already have de stents. May want to discuss about Lovenox (enoxaparin) with short half life. Your doctor has to observe you closely. Good luck. ...Read moreSee 1 more doctor answer
Usually not: In children with EDS, excessive bruising is often the presenting complaint to the pediatrician. Hematological studies including evaluation of clotting factors, platelet aggregation and bleeding time are usually normal in patients with EDS, Capillary fragility is usually cause of bruising in EDS.Generalized vascular fragility largely dominates the clinical picture. ...Read more
Why is it that aspirin can prevent blood clots in arteries but not in veins? If it inhibits platelet function, why does it not do that everywhere?
It does: It does inhibit platelet function. It does inhibit clot formation in veins. Its just that venous clots aren't quite as serious an issue. We worry about clots in the arteries to your heart that can lead to heart attack or an artery to your extremity leading to cold leg or arm. People do get clots in their veins, they are called DVTs but they usually aren't fatal. ...Read more
Tattoo: Safe under experienced tattooer, as long as no infection occurs (clean instrument, gentle hands). ...Read more
Prolonged collagen/epinephrine occlusion time but normal collagen/ADP and no aspirin or other NSAID. Is this a platelet function disorder? Which?
Platelet function test: collagen epinephrine normal, but ADP prolonged by 25 sec. Possible causes? Have normal CBC, PT, aPTT, CRP, d-dimer, comp met.
Aspirin exposure: This pattern of results could be from ingesting aspirin in some way. Aspirin (acetylsalicylic acid) is found in many things these days, including migraine meds, suppositories, fever/cough/cold relievers, & other OTC medications. Also, salicylate (salicylic acid), a prescription med for joint pain possible. Lastly, Plavix (clopidogrel) & other newer prescription meds aren't excluded. Happy hunting 4 u & ur doc! ...Read moreSee 1 more doctor answer
Can Lexapro (escitalopram) be taken with plavix, 81mg asprin and 5 mg lisiniprol? I read it may incr. Ssri levels and anti platelet effects. What does that mean?
Use with caution: As with all meds, use is determined by balancing benefits against potential adverse rxns. You're right on both counts: there is incr. Ssri levels and more anti-platelet effect. Beware of abn. Bleeding/bruising. Hyperreflexia and tremor can occur. Rarely, more serious effects like anxiety, agitation, tachycardia and altered thinking (serotonin sydrome). ...Read moreSee 1 more doctor answer
In general, is risk for acute stent occlusion of celiac artery high 6months after placement if decreasing anti-platelet therapy from Plavix to aspirin?
Plavix: When dealing with stents placed in a coronary artery switching from plavix to aspirin after 6-12 months has been standard and without problems for occlusion for the most part. Since most physicians don't have experience with celiac artery stents, a vascular surgeon with lots of experience in that regard is best qualified to answer your question. ...Read more
Pernicious Anemia :B12 injections every 2 mths would taking 15 mg Lansoprazole every day for two years with Plavix to protect the stomach from side effects from Anti-platelet .Could this deplete B12 and magnesium and cause neurological symptoms?
No: And if you want another way to get extra B12, you can get B12 pills OTC. Take 1000 unit pill once a day. Will yield same result as injections. Do you really need Lansoprazole???? Are you sure? Why taking Plavix for 2 years? Usually Plavix is used for 6 to 12 months after a stent or CABG. You should be taking an uncoated baby aspirin once a day. ...Read more
Why we usually give aspirin daily in stroke and ihd although it irreversible inhibitor of platelet agreggation and platelet life 10 days?
Low platelet count & Splenomegaly .ADP Aggr is mild impaired, Platelet Morph Aggr is OCC Enlarged suggestive of P2Y12-Inhibitor Effect
What it means?
Liver activation: Plavix (clopidogrel) is a pro-drug which is inactive. upon oral administration, Plavix (clopidogrel) is activated in the liver to become the active drug, injection of Plavix (clopidogrel) will bypass the liver activation of phase of the drug. clinical studies of Plavix (clopidogrel) were done with oral administration, there are however other medications used in the hospital setting that are injectable, however used in the setting of heart attacks ...Read more
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