Doctor insights on:
How Do Prions Enter The Body
By mouth: These abnormal proteins which can lead to brain degeneration are in food containing brain tissue from affected animals. Herds are checked for this so this incidence is very rare. Cooking does not destroy them. There are probably 1-3 cases of this in the us per year. ...Read more
Cut skin, ingestion: Ingestion by eating or through broken skin is best established but I would not exclude the possibility of spread through mucosal membranes of the eyes and nose. ...Read more
Unknown and yes: We all have the prion protein in our dna. Its normal function is unknown. Problems occur when something causes this protein to misfold. Misfolded prion protein may induce normally folded prion proteins to also misfold. It is unknown how many misfolded prion proteins are needed to cause disease. Recent research suggests misfolded prions may shut down protein synthesis. Nature 2012, 1476-4687. ...Read more
Are Prions the only free-roaming infectious disease? Are Toxins free roaming also? I imagine the body records everything that 1 is exposed 2?
Unclear: Prions, which are microscopic protein particles, are not free roaming. Infection by then is very rare and has been primarily associated with contaminated beef, monkey and other exotic animals. Mad cow disease, kuru, and Jacob Kreutzfeldt disease are the most well defined illnesses. I do not understand your question about the body's recording. Do not concern yourself. Or avoid beef and other meats ...Read more
If prions are not alive and have no DNA how could we tell if they are damaging nerve cells in the brain and body and what causes prions to damage us?
Change in shape: Prions appear to damage cell proteins by twisting them into unnatural configurations that accumulate in the cells and disrupt normal function. ...Read more
Not temp: It's a good question. Many bacterially affected food can be made safe by high temperature. Not so for prion infected meat. This means that whether cold or hot, badly prion infected meat cannot be made safe by heating. The good news is that prion-dangerous beef is exceedingly rare, whether processed or butchered. ...Read more
Yes: Traditionally classified human prion diseases include creuztfeld-jakob diseases (cjd), gerstmann-straussler-scheinker (gss) disease, fatal familial insomnia and kuru. Certain animal prion disease can be transmitted to humans including bovine spongifrm encephalopathy (mad cow disease), chronic wasting disease of mule deer and elk, and scrapie in sheep and goats. ...Read more
Tough question: There are about two dozen known prion diseases caused by more or less distinct prions. Yet the underlying prions do fal, into two large classes. Then there are normal prion type proteins found throughout the body and in the brain. The truth is that this is afield of such new and active research that a solid taxonomy has not yet been developed (so far as I know). ...Read more
Benefit provided: A plasmid is a small, self-replicating segment of bacterial dna (chromosome) that exists only within a cell and are usually of benefit to the bacteria. A prion is a protein that is considered infectious, specifically increasing the number of proteins that become like itself: they can convert proteins to prion status. ...Read more
???: What are you asking? And why? We are unable to help unless you are specific. ...Read more
Protein frags: Prions are very small proteins, often described as protein fragments because they are too small to have once been thought as having any bio function. So, like proteins, they are strings of amino acids. High concentrations of certain abnormal prions can replicate themselves and cause illness (as colleagues have described). But normal prions are found throughout the body. ...Read more
Not very: Hi, the most common prion disease is CJD, with a uniform incidence of approximately 1 case per million population both in the United States and internationally. Familial forms of prion diseases, such as GSS and fatal familial insomnia (FFI), are much more rare. About 10% of cases of CJD are familial, with an autosomal dominant pattern of inheritance linked to mutations in the PRNP gene. ...Read more
Infections: Prions and viruses can be transmitted from person to person, animal to animal. That is the only characteristic that is in common between viruses and prions. Viruses have typical genetic material, either dna or rna, and work with the host cell's own genetic machinery. Prions are abnormal proteins that encourage abnormal folding of proteins in the host. ...Read more
Structure change: Prions are abnormally folded versions of normal proteins. When a prion comes into contact with the "normal" version of itself, it changes the normal protein's structure into a prion. ...Read more
Yes: Some people may continue to aspirate while on G tube. Those patients may benefit from Jejunostomy tube ...Read more
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