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Doctor insights on: How Do Antipsychotics Work

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How do antipsychotics work?

How do antipsychotics work?

Block dopamine : Each antipsychotic has a slightly different receptor profile, but the one thing they all have in common is Dopamine receptor blockade. Though other factors may play a role, it is commonly accepted that increased Dopamine transmission is a major component for the development of psychosis. ...Read more

Dr. John Moranville
339 doctors shared insights

Antipsychotics (Definition)

These are medications used among other things to treat psychosis. There are two poorly named classes: the typicals, because they used to be typically used, and the atypicals, which are now typically used. They differ in that the so called atypicals are non-neuroleptics and interact with both serotonin and Dopamine receptos, while the typicals ...Read more


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How do antipsychotic medications work?

Dopamine blockade: Antipsychotics can work on various neurotransmitters in the brain, but the most frequent mechanism of action is to block brain dopamine receptors. Different medications impact different receptor subtypes and lead to varying effects. ...Read more

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How long do most antipsychotics take to work?

2-3,weeks to start: Can get sedative side effects right away--when used to augment antidepressants 3-4 days ...Read more

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How can antipsychotics work for anxiety?

Anxiety: Antipsychotics, especially sedating ones, are occasionally used for agitation, especially in bipolar or psychotic cases, not for anxiety per se. ...Read more

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Does fasting on antipsychotics inhibit there ability to work?

some yes, not yours: But long-term starvation would. If you are fasting for religious purposes, then it is fine .If you have anorexia, please do not use this information as permission to abstain from eating. Some antipsychotics require food for absorption, but Haldol (haloperidol) and seroquel which you are taking do not.Best wishes. ...Read more

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I take antipsychotics gained 100 pounds diet excersise doesn't work on the med but helps me sleep and helps mood would weight surgery be option?

I take antipsychotics gained 100 pounds diet excersise doesn't work on the med but helps me sleep and helps mood would weight surgery be option?

Weight loss surgery.: Weight Loss surgery would be an option for you. You'd need to meet with your psychologist or psychiatrist to see if mentally you'd be an appropriate candidate for such surgery. ...Read more

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Can the new bloodtest for schizophrenia only work if I am off antipsychotic drugs when I do the test?

On hold: The test verapsych looks for biomarkers of the illness and would not be affected by taking antipsychotic medication however use of the test has been suspended pending more research to support its usefulness. ...Read more

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If you stop taking an antipsychotic does it create a psychosis? Is this really how i was before? I could work on acknowledging though so i don't a prob

If you stop taking an antipsychotic does it create a psychosis? Is this really how i was before? I could work on acknowledging though so i don't a prob

Talk to your doc: Talk to your doctor before doing anything. Stopping an antipsychotic does not directly cause psychosis. However, people with a chronic or relapsing psychotic disorder relapse much more rapidly, in schizophrenia the relapse rate off meds is about 10% per month. ...Read more

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If 2.5 klonopin (clonazepam) works fine for mood and racing thoughts ..Would not it be safer than the stronger anticonvultants and atypical antipsychotics.

If 2.5 klonopin (clonazepam) works fine for mood and racing thoughts ..Would not it be safer than the stronger anticonvultants and  atypical antipsychotics.

In some ways ...: ...It is safe---it is generally well-tolerated, and other than the possibility of sedation, the main issue is addiction when used regularly. It does not have the baggage of the metabolic effects like the atypicals or the effects on the liver or worries of rashes like the anticonvulsants. But unfortunately, chronic use of Klonopin (clonazepam) creates its own addiction. ...Read more