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Doctor insights on: How Dangerous Is Exposure To Cytotoxic Drugs

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How dangerous is exposure to cytotoxic drugs?

How dangerous is exposure to cytotoxic drugs?

Potential problem: Exposure related to nurses, pharmacists over a prolonged period can be a problem. A very short exposure (spill of drug or brief contact with skin can not be a problem. Be careful to protect yourself when cytotoxic drugs may be involved. ...Read more

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Which is the better cytotoxic drug if pregnant. I have been advised to take chemo?

Which is the better cytotoxic drug if pregnant. I have been advised to take chemo?

Uncertain: This is a complex question and you need to discuss it with your oncologist. If he or she is not certain, you could also consult a high risk obstetrician. It is usually a balance between what your disease is and the urgency of treatment and the gestational age of the fetus and what medication choices exist. ...Read more

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Which is the better cytotoxic drug for synovial sarcome ---adriamycin or ifosfamide?

Which is the better cytotoxic drug for synovial sarcome ---adriamycin or ifosfamide?

Given together: This is an uncommon tumor. If chemotherapy is used these drugs are often give together. It would be difficult to really say that one is clearly better. ...Read more

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Which is the better cytotoxic drug (adriamycin (doxorubicin) or ifosfamide) for synovial sarcoma?

Equally effective: Synovial sarcomas when first seen i.e. in the lower leg/foot area must be resected to obtain cure. If seen late and mets have occurred, in selected areas such as a solitary lung or liver lesion, then resection employed. If multiple mets present then Adriamycin (doxorubicin) and or ifosfamide in combination with carboplat and other drugs may be needed. Chemosensitization studies of fresh tumor bx can help. ...Read more

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What is cytotoxic hypersensitivity (type 2)?

What is cytotoxic hypersensitivity (type 2)?

Type II hypersensitivity: Or cytotoxic reactions, are antibody dependent, IgG or IgM binds to the own body cell surface after being altered by a protein, so the immune system recognizes as non-self (foreign) attacks and destroys the cell by fixing a protein called complement, which in turn forms the Membrane Attack Complex and destroy the cell, the most famous is hemolytic anemias and some auto immune diseases ...Read more

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What are t-helper cells/cytotoxic cells?

What are t-helper cells/cytotoxic cells?

Lymphocyte family: These are a special group of white blood cells that actually kill cells that the body perceives to perhaps be infected. This is usually, but not always, a good thing. We pathologists recognize them as cd8+, staining brown with a special stain. I'm glad you're interested in the immune system, which still amazes scientists. Thanks for asking. ...Read more

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What will happen when a person in unable to present antigens to cytotoxic t cells?

What will happen when a person in unable to present antigens to cytotoxic t cells?

Depends: This depends on the antigen. For example, natural killer cells (NK) act as "innate" or native destroyer of invaders and thus a deficiency would increase susceptibility to infections and perhaps even cancer. Cytotoxic T cells works in the same manner but are more likely related to induced responses. Not all antigens are harmful to us and thus you need to be more specific in your question. ...Read more

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What is the least cytotoxic root canal filler?

What is the least cytotoxic root canal filler?

Calcium Carbonate: Gutta percha is the standard by which all root canal material are judged, and for good reason; it works over 90% of the time. However, it is cytotoxic. There is a system that uses calcium carbonate to fill root canal teeth, but there is not addquate evidence to say how well it works or if it is cytotoxic, but it is unlikely that it is cytotoxic. ...Read more

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Why dont MHC 1 complexes present ALL HIV fragments to cytotoxic T cells in order for host cell degradation in order remove all HIV from every cell?

Why dont MHC 1 complexes present ALL HIV fragments to cytotoxic T cells in order for host cell degradation in order remove all HIV from every cell?

In the genes: DNA integrated into the genome is undetectable, of course, and once the cells start making more HIV it happens faster than the imimune cells can stop it. HIV has other ways of escaping surveillance as well, more than 400 characters can cover -- you can find plenty to read with help from a good medical librarian. Best wishes. ...Read more