Doctor insights on:
How Could Vasoconstriction Affect Cardiac Output
Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, particularly the large arteries and small arterioles. The process is the opposite of vasodilation, the widening of blood vessels. The process is particularly important in staunching hemorrhage ...Read more
Yes: Yes you can call spasm of the corner arteries avoid this with significant coronary disease. ...Read more
Does an adrenaline surge (from anxiety or exercise) when taking a non-selective B-blocker cause coronary vasoconstriction? Selective B1-blckr better?
Beta blockers: B blockers are used to treat angina caused by coronary disease, and they are effective. They reduce heart rate and the workload of the heart, including response to exercise. With very high norepinephrine conditions, eg. pheochromocytoma, blocking beta can cause unopposed alpha and raise BP. But that is a very rare condition. ...Read more
No evidence seen:
Mididrine is an alpha1-agonist and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure.
There is some recent evidence in animal coronaries there are Alpha and beta receptors in large coronaries and beta in small coronaries, but no data avialabe for midodrine. ...Read more
If Nictotine causes coronary & cerebral vasoconstriction why doesn't it cause angina or light headedness in people running with a HR of 180BPM?
Internal controls: Dominate responses, not chemistry administered from outside; despite marketing to the contrary. Medicine is low-Tech: the Hi-Tech (as embodied Soul↔Mind↔Brain↔Body creatures sending >1, 000, 000 orders/sec brain→body with similar feedback) is within. Artery & arteriole control is from brain plus local control. Study: http://goo. Gl/zZT5ou & https://goo. Gl/xqf4e4 for better understanding. ...Read more
Does a cigarette cause coronary artery vasoconstriction? If yes, wouldn't this cause a angina if you started exercising?
Vasoconstriction: Cigarettes are associated with coronary artery vasoconstriction. This constriction could cause angina if combined with exercise in some people, but it would not do so in everyone. Much of the response would be based on the underlying health of the heart and coronary arteries. ...Read more
Does nicotine cause a big vasoconstriction effect on coronary arteries? If any how long does it last? Surely body would override to myocardium needs?
Low blood pressure: Cardiac output is related to the heart rate, and volume of blood the heart can pump with each heart beat. A low cardiac output occurs when the pump function of the heart is compromised by an event such as a heart attack or when the blood volume is reduced by and event such as dehydration, or bleeding. ...Read more
Low cardiac output: Cardiac output depends on heart rate and stoke volume. Therefore, the cardiac output increases when heart rate goes up in normal heart. However, when the heart is failing the stroke volume is lower as well as the cardiac out which is called heart failure. Sometimes, heart failure could occur when cardiac output is high due to other medical problems such as a severe anemia, hyperthyroidism, etc ...Read more
Two ways: It can cause the heart muscle to get thick and stiff so that it does not relax and fill up with blood properly. It could also cause the heart muscle to become weak so that it does not squeeze or contract as forcefully. These are called diastolic dysfunction (too thick) or systolic dysfunction (weak and flabby). ...Read more
Cardiac output: Is stroke volume times heart rate. If stroke volume goes down more than heart rate goes up, cardiac output won't increase. Stroke volume depends on preload (filling of the heart), afterload (resistance to flow), and contractility (how much the heart pumps for how much it is filled. For instance, if the heart rate goes up but the the heart doesn't have time to fill, output won't increase. ...Read more
Hyperthyroidism: Hyperthyroidism is a excess metabolic state. If other systems are normal it will usually cause increased heart rate and cardiac output. In the face of a weak heart, it could be associated with decrease in cardiac output. Chronic hyperthyroidism can be associated with a cardiomyopathy causing decreased heart function. ...Read more
Venoconstriction?: Cardiac output is inversely proportional to total peripheral resistance (which is related to mean arterial pressure.) venoconstriction refers to the venous system and can't be measured. If venous return increases, preload increases, and by starling's law of the heart, cardiac output increases. However, severe venoconstriction could eventually diminish venous return and reduce co. Yes? ...Read more
Cardiac output: In strict physiologic terms, cardiac output is determined by something called stroke volume and heart rate. Heart rate is self-explanatory. Stroke volume is the amount of blood that the heart pumps out with each beat. This in turn is dependent on blood pressure, total blood volume, and how strong the heart contracts. ...Read more
In general four: Cardiac output is influence by the amount of blood the heart recieves, the resistance against which the blood is ejected, the strength of contraction and the heart rate. For ex. CO increases with heart rate, increase in blood volume, increase in cardiac contraction and less resistance to ejection because of lower peripheral resistance. Clinical conditions that affects any 4 will alter cardiac output ...Read more
CO=need: Your cardiac output will match your need. The difference between an athlete and a non-athlete is that the athlete can increase their co and reduce their need at peak exertion through conditioning and the rest of us can't. Think of a race car and an oldsmobile (both 8 cyl) traveling at 25 mph. They both use the same amount of gas but the former can go 200 mph, while the latter is sputtering at 100. ...Read more
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