Doctor insights on:
How Common Is The Sickle Cell Disease Trait In America
This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more
If my boyfriend has sickle cell anemia and I don't have neither the trait or disease, will our child end up having it?
No: If your boyfriend has sickle cell anemia (2 abnormal genes) and you have 2 normal genes, then your children will all have sickle cell trait but none will have the disease. You need to be sure you have no other blood abnormalities like thalassemia or hemoglobin c trait which can be totally asymptomatic; this would change the answer significantly! ...Read moreSee 2 more doctor answers
Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms. ...Read more
Gene mutation: Sickle cell trait is caused bu the presence of a single mutation in the beta chain of human hemoglopin a gene. A mutation in one gene on one of a person's two beta globin genes results in sickle cell trait (sa hemoglobin) while the same mutation in both of a persons genes causes sickle cell anemia. (ss hemoglobin). The term trait means a carrier for the sickle cell mutation. ...Read more
My spouse is a carrier of the trait but I am not. What are the chances of our kids having sickle cell disease?
None: If you know for sure that you are not a carrier of the trait, your child will not have sickle cell disease. However, you have a 50% chance of having a child with the trait. The good news is that people with the sickle cell trait usually have very few (or no) medical problems. ...Read moreSee 2 more doctor answers
Proper care needed: As long as they are under proper medical attention there should be no problem. ...Read more
No: It is always a good idea to get up and walk around a little bit on long flights, as the flights themselves increase the risk of getting a clot in the legs (lower extremities). However the sickle cell trait does not place you at any higher of a risk for a venous clot than the general population. ...Read moreSee 1 more doctor answer
Carrier vs. Affected: Sickle cell trait denotes being a carrier while sickle cell disease is someone who has the disorder. Sickling requires 2 genes. A person with the s gene and a normal gene would be a carrier and considered to have sickle cell trait. Someone who has s and s would be considered to have sickle cell disease and would likley be affected. ...Read more
If you have only the sickle cell trait, can you sometimes suffer like a person who has the disease?
On rare occasions: People with sickle cell trait under normal conditions (climate, altitude, normal life style) do not have any symptoms of sicle cell disease. Very occasionally individulas who had severe stressful conditions (boot camp under extreme heat and with dehydration), or worked under significanly reduced oxygen pressure (high altitude) did experieince vaso-occulsive crisis. Or had sudden death. ...Read moreSee 1 more doctor answer
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