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Doctor insights on: How Common Is A Positive Ana In Scleroderma

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How common is a positive ANA in scleroderma?

How common is a positive ANA in scleroderma?

Common: Ther are some special ANA patterns that are seen depending on what type of scleroderma you have. People with limited scleroderma can have an anti-centromere pattern. People with diffuse scleroderma can have an anti- nucleolar pattern and can also have certain autoantibodies such as scl-70. If you have a scleroderma overlap syndrome you may have other patterns depending on the overlap. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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I have a positive ANA 1:640 homogenous nuclear staining. Does this mean scleroderma or lupus? I also have a very slightly elevated angiotensin conv en

Depends: No diagnosis can be firmly established with a single blood test even in your case. Bone pain is not the usual manifestation of an autoimmune disease. Why was the test ordered in the first place? If your doctor suspects the presence of an autoimmune disorder, more tests will be needed to pin down the diagnosis. ...Read more

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Other than crest/scleroderma what other virus/bacteria/disease can cause a positive ANA with centromere pattern?

A lab error: The evaluation of these things by an inexperienced technician / pathologist is fraught with possibilities for error. ...Read more

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Very scared I have scleroderma as I have a positive ANA nucleolar but negative subtests 1 1/2 years ago. I don't have any usual symptoms just eye problems like episcleritis once. How long until someone can say its not scletoderma ot am I a sitting duck

Very scared I have scleroderma as I have a positive ANA nucleolar but negative subtests 1 1/2 years ago. I don't have any usual symptoms just eye problems like episcleritis once. How long until someone can say its not scletoderma ot am I a sitting duck

RELAX!: All the "auto-immune" diseases present in a spectrum of symptoms. You are lucky in that you seem to have minimal symptoms. Don't wait for someone to say it is or is not "xyz" disease-live well;know that these conditions have a stress component that you can reduce with exercise, diet, and relaxation efforts. Expect the best but be prepared if worsening occurs. Outcomes will be effected. ...Read more

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Scared! I had a positive ANA twice 1:40 and 1:160 nucleolar pattern only symptoms have been mild dry eye and one possible episode of episcleritis in the last year. I am scared I have diffuse scleroderma. Been to several rheumatogists and dermatolog

Scared! I had a positive ANA twice 1:40 and 1:160 nucleolar pattern only symptoms have been mild dry eye and one possible episode of episcleritis in the last year. I am scared I have diffuse scleroderma. Been to several rheumatogists and dermatolog

Relax!: Take a deep breath! Having a positive ANA doesn't mean that you have a particular disease. In fact lab testing is only a part of the diagnosis, the main part is the clinical picture. Is a good thing to be on top of your health, but being too much can be harmful too. You have already consulted specialists in that area. Follow their recommendations. ...Read more

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I have a positive ANA Profile the Scleroderma SCL -70 was 1.8 AI. I have been experiencing fatigue, and joint pain in my hands, ankles and feet. I ha?

I have a positive ANA Profile the Scleroderma SCL -70 was 1.8 AI. I have been experiencing fatigue, and joint pain in my hands, ankles and feet. I ha?

See a rheumatologist: Your symptoms may be consistent with an autoimmune disease. The ANA and positive SCL 70 are markers which SOMETIMES are associated with certain autoimmune diseases. A Rheumatologist will help you see if you have one of these. ...Read more

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Am I a person with diffuse scleroderma if positive ANA 1:40 and 1:160 1 1/2 years ago but negative subtests and no symptoms except episcleritis once?

Am I a person with diffuse scleroderma if positive ANA 1:40 and 1:160 1 1/2 years ago but negative subtests and no symptoms except episcleritis once?

I don't think so.: Diffuse scleroderma would likely be rapidly progressive, with symmetric skin thickening of extremities, skin and trunk. Visceral involvement is also more likely sooner, like renal and cardiac involvement. Also things like ESR would be elevated. Apparently positive ANA anticentromere pattern would be associated with the limited cutaneous or crest form of scleroderma. See your dr. For more tests. ...Read more

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Ana positive 1:80 homogeneous pattern & 1:160 centromere pattern...Additional tests needed or just by centromere pattern crest & scleroderma r present?

Almost certain: Positive anti-centromere antibodies would indicate the presence of scleroderma/crest, better if anti–scl-70 antibodies also present, plus clinical symptoms and signs. ...Read more

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How do you determine if IBS is due to scleroderma when ANA positive but no other symptoms?

You cannot!: ANA is not a test specific for scleroderma, and there are false positives. There are several subtypes of scleroderma too, such as localized, systemic sclerosis, crest, syndromes, and single internal organ involvement. Several major and minor criteria must be met to make a diagnosis of systemic sclerosis. A skin biopsy is essential, if clinical exam is suspicious for cutaneous scleroderma. ...Read more

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Ana positive c3c low and low phosphate no symptoms of anything does this mean lupus or since ANA was nucleolar scleroderma or not necessarily auto immune issue?

Why the test?: If you don't have symptoms of anything, why did you have the test in the first place? Tests should be ordered when there is a reasonable suspicion of disease through the questioning and physical examination. Having a positive ANA alone means nothing. ...Read more

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Do I have scleroderma 46 year old female positive. Ana two times 1:40 and 1:160 negative nucleolar pattern negative subtests. No skin issues, eye irritation once in awhile. Ana tests done 1 1/2 years ago. Rheumatalogist finds nothing except ANA and I

Do I have scleroderma 46 year old female positive. Ana two times 1:40 and 1:160 negative nucleolar pattern negative subtests. No skin issues, eye irritation once in awhile. Ana tests done 1 1/2 years ago. Rheumatalogist finds nothing except ANA and I

Unlikely: The combination of your very low ANA titers and lack of symptoms make scleroderma unlikely. Patterns of ANA are not reproducible, and an ANA titer of <1:80 has been reported in up to 13% of healthy patients. Ana is a screening assay which should be followed by a more specific autoantibody tests. 95% of scleroderma patients will have an identifiable positive autoantibody. (uptodate. Com, 7/16/12). ...Read more

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Do I have scleroderma 46 year old female positive. Ana two times 1:40 and 1:160 negative nucleolar pattern negative subtests. No skin issues, eye irritation once in awhile. Ana tests done 1 1/2 years ago. Rheumatalogist finds nothing except ANA and I

Nothing to do: The only thing you can do is to wait. In rheumatologic diseases, the components of the syndrome sometimes don't manifest at once but during the curse of several years. Worrying now for something that can be nothing is not good for your mind. Positive ANA test doesn't mean that you have a disease. ...Read more

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Ana positive, 1:320 centromere pattern. Some joint pain, some swelling, fatigue. Could I have lupus or scleroderma?

Ana positive, 1:320 centromere pattern. Some joint pain, some swelling, fatigue. Could I have lupus or scleroderma?

See below: Lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. The information you provided suggests scleroderma/crest. See this site for more info and discuss with your doctor. Http://www. Mayoclinic. Com/health/scleroderma/ds00362. ...Read more

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Messed up question do I have scleroderna last year tested ANA positive 1:40 and 1:160 nucleolar pattern but negative subtests including sl70 have no real symptoms no skin issues have red veins on arm when cold and episcleritis one time but not definite d

Messed up question do I have scleroderna last year tested ANA positive 1:40 and 1:160 nucleolar pattern but negative subtests including sl70 have no real symptoms no skin issues have red veins on arm when cold and episcleritis one time but not definite d

Maybe limited form.: Diffuse scleroderma would likely be rapidly progressive, with symmetric skin thickening of extremities, skin and trunk. Visceral involvement is also more likely sooner, like renal and cardiac involvement. Also things like ESR would be elevated. Apparently positive ANA anticentromere pattern would be associated with the limited cutaneous or crest form of scleroderma. See your dr. For more tests. ...Read more

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Tested positive for 2nd time ANA 1:160 centromere on 3/4 n 4/5. Tested neg 4 sl-70. What additional test can be done to rule out crest/scleroderma?

See details: You keep asking the same question over and over again. There is no additional testing. You either have clinical symptoms consistent with the diagnosis or you do not. If you do not, then you do not have the diagnosis. ...Read more

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Low amylase blood level, tryglerides 934, cholesterol 264, HDL 42, non HDl 226, creatine 1, 09, bun 23, I have lupus/scleroderma ana positive, ifa pos.

Low amylase blood level, tryglerides 934, cholesterol 264, HDL 42, non HDl 226, creatine 1, 09, bun 23, I have lupus/scleroderma ana positive, ifa pos.

Hyperlipidemia: Your serum lipids are very abnormal and require dietary and most likely medication for treatment. If untreated you are predisposed to cardiovascular complications. Very high triglycerides predispose to pancreatitis. Your physician and/ or rheumatologist will refer you to a dietitian and advise you on medications, avoidance of alcohol and the follow-up needed. ...Read more

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Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?

Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?

Occam's Razor: Usually Systemic Sclerosis and/or limited Scleroderma is not characterized by arthritis like you describe. The typical biomarker the anti Scl-70 (anti-topoisermorase). Symptoms have to be put into context and better described than elbow and forearm pain. This one you should see a rheumatologist about. Dermatology would be useful as well. Best of luck! ...Read more

Dr. Pierre Moeser
182 Doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


Dr. Erik Borncamp
140 Doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis = scleroderma = autoimmune disease affecting connective tissue & blood vessels. It causes skin to thicken asymmetrically due to deposits of fibrous connective ...Read more