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Doctor insights on: How Common Is A Positive Ana In Scleroderma

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How common is a positive ANA in scleroderma?

How common is a positive ANA in scleroderma?

Common: Ther are some special ANA patterns that are seen depending on what type of scleroderma you have. People with limited scleroderma can have an anti-centromere pattern. People with diffuse scleroderma can have an anti- nucleolar pattern and can also have certain autoantibodies such as scl-70. If you have a scleroderma overlap syndrome you may have other patterns depending on the overlap. ...Read more

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Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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I have a positive ANA 1:640 homogenous nuclear staining. Does this mean scleroderma or lupus? I also have a very slightly elevated angiotensin conv en

Depends: No diagnosis can be firmly established with a single blood test even in your case. Bone pain is not the usual manifestation of an autoimmune disease. Why was the test ordered in the first place? If your doctor suspects the presence of an autoimmune disorder , more tests will be needed to pin down the diagnosis. ...Read more

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Other than crest/scleroderma what other virus/bacteria/disease can cause a positive ANA with centromere pattern?

A lab error: The evaluation of these things by an inexperienced technician / pathologist is fraught with possibilities for error. ...Read more

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Very scared I have scleroderma as I have a positive ANA nucleolar but negative subtests 1 1/2 years ago. I don't have any usual symptoms just eye problems like episcleritis once. How long until someone can say its not scletoderma ot am I a sitting duck

Very scared I have scleroderma as I have a positive ANA nucleolar but negative subtests 1 1/2 years ago.  I don't have any usual symptoms just eye problems like episcleritis once.  How long until someone can say its not scletoderma ot am I a sitting duck

RELAX!: All the "auto-immune" diseases present in a spectrum of symptoms.You are lucky in that you seem to have minimal symptoms.Don't wait for someone to say it is or is not "xyz" disease-live well;know that these conditions have a stress component that you can reduce with exercise, diet, and relaxation efforts.Expect the best but be prepared if worsening occurs.Outcomes will be effected. ...Read more

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Scared! I had a positive ANA twice 1:40 and 1:160 nucleolar pattern only symptoms have been mild dry eye and one possible episode of episcleritis in the last year. I am scared I have diffuse scleroderma. Been to several rheumatogists and dermatolog

Scared!  I had a positive ANA twice 1:40 and 1:160 nucleolar pattern only symptoms have been mild dry eye and one possible episode of episcleritis in the last year.  I am scared I have diffuse scleroderma.  Been to several rheumatogists and dermatolog

Relax!: Take a deep breath! having a positive ANA doesn't mean that you have a particular disease. In fact lab testing is only a part of the diagnosis, the main part is the clinical picture. Is a good thing to be on top of your health, but being too much can be harmful too. You have already consulted specialists in that area. Follow their recommendations. ...Read more

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I have a positive ANA Profile the Scleroderma SCL -70 was 1.8 AI. I have been experiencing fatigue, and joint pain in my hands, ankles and feet. I ha?

See a rheumatologist: Your symptoms may be consistent with an autoimmune disease. The ANA and positive SCL 70 are markers which SOMETIMES are associated with certain autoimmune diseases. A Rheumatologist will help you see if you have one of these. ...Read more

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Ana positive 1:80 homogeneous pattern & 1:160 centromere pattern...Additional tests needed or just by centromere pattern crest & scleroderma r present?

Almost certain: Positive anti-centromere antibodies would indicate the presence of scleroderma/crest, better if anti–scl-70 antibodies also present, plus clinical symptoms and signs. ...Read more

Dr. M. Hytham Beck
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Dermatosclerosis (Definition)

Dermatosclerosis (also known as scleroderma), is a disease of the connective tissue, causing tightening and ...Read more


Dr. Pierre Moeser
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Scleroderma (Definition)

Scleroderma is an autoimmune disease characterized by tightening of the skin on ...Read more