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Doctor insights on: How Can You Treat Progressive Supranuclear Palsy

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How can you treat progressive supranuclear palsy?

How can you treat progressive supranuclear palsy?

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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Palsy (Definition)

...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more


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What can cause progressive supranuclear palsy?

What can cause progressive supranuclear palsy?

Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more

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How is progressive supranuclear palsy (psp) diagnosed?

How is progressive supranuclear palsy (psp) diagnosed?

Cannot look up: Similar to but worse prognosis than parkinson's disease sharing the rigidity and poverty of movements, inability to look up with head kept straight. ...Read more

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What are the tests for progressive supranuclear palsy?

What are the tests for progressive supranuclear palsy?

Good History & exam!: Good history & exam are the keys. In expert hands, that is all you really need. However, a new test/imaging procedure called datscan can determine if the person is suffering from a true Dopamine degenerative state (parkinsonian sundrome) or not, it cannot destinguish b/w these parkinsonian syndromes, however! ...Read more

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What is the prognosis for progressive supranuclear palsy?

Supranuclear palsy: Unfortunately, no known treatment other than supportive care for supranuclear palsy exists. The average person is in their 60's when diagnosed. Life expectancy averages 7 years after diagnosis. ...Read more

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What are the symptoms that characterize progressive supranuclear palsy?

What are the symptoms that characterize progressive supranuclear palsy?

Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more

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Is possible for progressive supranuclear palsy to be cured / get better?

Is possible for progressive supranuclear palsy to be cured / get better?

Good Rx, but no cure: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

Dr. Justin ORourke
29 doctors shared insights

Supranuclear Palsy (Definition)

Supranuclear palsy is a rare brain condition that causes serious problems with walking, eye movements, and balance. The disorder develops slowly over time as the cells in parts of the brain that control movement are destroyed. Although there is no cure, there are ways ...Read more


Dr. Robert Hutchman
35 doctors shared insights

Progressive Supranuclear Palsy (Definition)

Progressive supranuclear palsy is a rare condition in which a person has a degenerative brain disease that damages nerve cells in the parts of the brain that control eye movements, breathing, swallowing, speech, ...Read more