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Doctor insights on: How Can The Cystic Fibrosis Gene Affect Tuberculosis

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How can the cystic fibrosis gene affect tuberculosis?

How can the cystic fibrosis gene affect tuberculosis?

Lung Function: The gene itself will not affect tuberculosis. However, if an individual receives 2 recessive genes of the cftr mutation from their parents, they will develop cystic fibrosis (cf). Because CF can lead to repeated bacterial lung infections (among other things), the lungs would already be in a weakened state if exposed to the causative agent of tuberculosis. This might lead to faster disease onset. ...Read more

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Dr. Scott Lindquist
561 doctors shared insights

Mycobacterium Tuberculosis Infection (Definition)

Mycobacterium tuberculosis infection is also known as Tuberculosis. Mycobacterium tuberculosis is an infectious organism that spreads by droplets coughed out by an infected person. Infection is established initially in lungs, but can spread within lungs & to other body parts, or can become latent, with reactivation occurring years to decades later. With effective treatment, it can be completely eliminated although drug resistant ...Read more


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Can a carrier of the Cystic Fibrosis gene ever be symptomatic?

Can a carrier of the Cystic Fibrosis gene ever be symptomatic?

Autosomal recessive: CF is an autosomal recessive genetic disorder. Complete expression of the disease (symptoms) do not typically occur in people who do not have both copies of the defective gene (carriers only have one). ...Read more

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What are the chances of passing on the Cystic Fibrosis gene if only one parent is a CARRIER? Other parent not a carrier.

What are the chances of passing on the Cystic Fibrosis gene if only one parent is a CARRIER? Other parent not a carrier.

50-50: One half of offspring will be carriers and one half will not be carriers. No offspring will be afflicted. Thanks for trusting HealthTap! ...Read more

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What affect does gene therapy for people with cystic fibrosis have on the evolution of human and/or other species?

What affect does gene therapy for people with cystic fibrosis have on the evolution of human and/or other species?

Same as...: ...Any other lifesaving interventions: it increases, by a tiny amount, the probability that more lifesaving interventions will be needed in the next generation. Considering that appendicitis and strep throat are among illnesses that killed people before such interventions were possible, CF is not a major contributor to evolutionary pressure. ...Read more

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Cystic fibrosis is a disorder of genes but which ones?

CF gene mutations: There are currently more than 1900 mutations that are known to cause cf. About 70% of CF pts in us have deltaf508 mutation, as 1 in every 25 persons is a carrier for this mutation. All these mutations result in abnormal activity of a protein called cftr which causes all the CF related problems. Genetic testing can give the specific mutation each pt has. Talk to your local CF center. ...Read more

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Can you explain if it's possible to get cystic fibrosis without carrying the genes for it?

Can you explain if it's possible to get cystic fibrosis without carrying the genes for it?

No: Cystic fibrosis (CF) is a genetically inherited disease, so CF or cf-related disease (atypical cf, crms) rely on having at least 1 inherited gene. The other part of CF diagnosis is having an elevated sweat chloride. It is possible to have a positive sweat chloride due to other circumstances (thyroid imbalance, trisomy 21), but without CF genetics, there cannot be a diagnosis of cf. ...Read more

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Me and my partner both carry cystic fibrosis genes. How do we be sure to have a child without cystic fibrosis?

Me and my partner both carry cystic fibrosis genes.  How do we be sure to have a child without cystic fibrosis?

Prenatal testing: Testing of your fetus and or placenta is available . However, there us a risk of pregnancy loss associated with these procedures. Talk with our obstetrician and genetic counselor about risks and the best procedure for your situation. ...Read more

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Say I have the gene of cystic fibrosis, can my child have it?

Say I have the gene of cystic fibrosis, can my child have it?

CFF: Both the mother and father have to be carriers. it is a genetic disease and genetic counseling is available. The CF foundation also has information about CF transmission. ...Read more

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Dr. William Walsh
974 doctors shared insights

Cystic Fibrosis (Definition)

Cystic fibrosis is a genetic disorder involving lungs & digestive tract, causing recurrent lung infections due to thick inspissated mucus & poor growth in majority of patients due to malabsorption. Treatment involves inhaled respiratory therapies to prevent lung disease & pancreatic enzymes to enable absorption of nutrients. Average life expectancy is near 40 years, ...Read more


Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more