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Doctor insights on: How Aggressive Is Synovial Sarcoma

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How serious is synovial sarcoma?

How serious is synovial sarcoma?

It's a cancer.: Synovial sarcoma is a rare cancer that arises near joints. Despite the name synovial, referring to the lining of joints, it almost never arises within a joint. Surgical removal is the mainstay of treatment. Radiation is often added to lower risk of it growing back. It is controversial if chemotherapy helps. While the majority of people are cured, it can be a deadly disease. ...Read more

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Dr. Mark Pack
2 doctors shared insights

Sarcoma (Definition)

By definition, it is malignant (i.e., being locally invasive and at least theoreticlally capable of metastasizing), and arises from / mimics muscle or connective tissue elements that are not marrow or immune / white cells. The sarcomas are a tremendously varied and troublesome family of tumors, though thankfully less common than carcinomas and the leukemia / ...Read more


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What are the symptoms of synovial sarcoma?

Growing mass : Synovial sarcomas tend to occur close to joints. They present as a lump which may grow, either quickly or slowly. Unlike other sarcomas, which are painless, synovial sarcoma may be painful. The name synovial is a misnomer. Synovium is the lining membrane of joints, but synovial sarcomas occur near, not in joints and have nothing in common with synovium. ...Read more

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What does it mean to have synovial sarcoma?

It's a cancer: It usually occurs in the soft tissues near joints. Unlike other soft tissue sarcomas, that are painless, it can be painful. It is treated with surgery and radiation. Use of chemotherapy if the tumor hasn't spread is controversial. If the cancer spreads, it usually goes to the lungs. With proper treatment, chances of survival are quite good. ...Read more

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What are the chances of one surviving synovial sarcoma?

>50% likely cure: Assuming the tumor has not metastasized to the lungs, a majority of patients with this cancer enjoy long-term survival with today's treatments, which are evolving. Since synovial sarcoma has a trademark genetic defect, a specific "magic bullet" may be discovered as has happened for similar cancers. I admire your courage and wish you luck. ...Read more

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What is the treatment for synovial sarcoma?

Surgery foremost: There are conflicting results on whether radiation and/or any chemotherapy protocol helps at any particular stage. If the tumor has not spread to the lungs, for most patients a 5-year disease-free survival is more likely than not. Unoperated, the disease is lethal. Good luck, and thanks for asking. ...Read more

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Are there any treatments for synovial sarcoma?

Yes: Treatment of synovial sarcoma is centered on surgical removal of the tumor with a cuff of normal tissue around it (medical term is wide resection). Radiation is given either before or after surgery in many cases. Use of chemotherapy is controversial as it gives a minimal improvement in survival rates at best. Chances of cure are about 60-70% overall, but every case is different. ...Read more

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Any docs familiar with synovial sarcoma? What can you tell me about it?

Rare cancer: It is a rare cancer that usually arises close to joints in younger people. Treatment is with surgery and radiation. It is not clear if chemotherapy helps, but of all sarcoma types, synovial may be more sensitive to chemo than others. If it is caught before it spreads, it can often be cured. If it spreads, it usually goes to the lungs and sometimes the lymph nodes. Need for amputation is rare. ...Read more

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What are the current immuno-therapies for synovial sarcoma? How effective are them?

Experimental: Despite "pop" claim and excitement, immunotherapy has historically been a bust for sarcomas. There 's some new stuff but it'a way early. There is a melanoma-sarcoma group at Sloan Kettering; Dr. D'Angelo may have something. Good luck. ...Read more

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Is synovial sarcoma a serious cancer?

Is synovial sarcoma a serious cancer?

Very: It will invariably kill if it is untreated. If it has spread to the lungs, we presently have no cure. If it has not, with today's therapy (surgery; the value of radiation and/or chemotherapy, depending on the stage of tumor and type of treatment) more than 50% of patients survive 5-years, the majority of these disease-free. Good luck. ...Read more

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What is the best treatment for synovial sarcoma?

What is the best treatment for synovial sarcoma?

Still under study: Everyone agrees that surgery is foremost. Whether local radiation and/or adjuvant chemotherapy (and if so what kind) are helpful is still up for grabs, with different studies giving different results for different stages of tumor. Unless the disease has spread to the lungs, the chances of long-term survival are generally better than even. Good luck. ...Read more

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