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Doctor insights on: Hla Typing For Celiac Disease

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Dr. Michael Dugan
11 doctors shared insights

Hla Typing (Definition)

Describes the determination of proteins on the cell surface which the immune system utilizes to assign self and not self. There are multiple genes which encode these ...Read more


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What is the definition or description of: hla typing?

What is the definition or description of: hla typing?

HLA typing: Describes the determination of proteins on the cell surface which the immune system utilizes to assign self and not self. There are multiple genes which encode these proteins on chromosome 6. ...Read more

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What is hla-typing or "tissue typing?" what is tissue crossmatch?

What is hla-typing or "tissue typing?" what is tissue crossmatch?

Donor-Recipient: These are all methods of determining compatibility between donor and recipient with organ and tissue transplants. Everyone has certain protein and carbohydrate markers on the outside of every cell. These make us unique, but also are potential allergens between people. To help prevent rejection (which can be life-threatening) we try to make sure the markers are alike as possible in both people. ...Read more

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With regards to hla typing, is mhc-1 matching or mhc-2 better to avoid a graft rejection?

With regards to hla typing, is mhc-1 matching or mhc-2 better to avoid a graft rejection?

In the arena of stem: Cell transplantation this is more defined than in the past. Class one match (hla a, b and c) and class two (hla dr and dq) are all performed at high resolution (gene level tryping). The best match with all loci evaluated will produce the lowest chance of graft rejection. Mis-match can be assessed in the gvhd and host vs graft (rejection) direction. ...Read more

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What are indications of hla typing?

What are indications of hla typing?

Immunology: Usually hla typing is performed to look for immune compatibility (or lack thereof). Examples include transplant, platelet transfusion, and certain autoimmune diseases. ...Read more

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How do people get celiac disease?

How do people get celiac disease?

Genetics; eat gluten: Celiac disease (gluten allergy) occurs in a person who may have a genetic tendency to react abnormally to gluten (a protein in wheat, barley, and rye). Something causes his immune system to over-react to gluten. Later, when he eats foods containing gluten, his immune system reacts with the intestine that is digesting the gluten, and causes intestinal damage, abnormal digestion, plus malabsorption. ...Read more

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Do you know about celiac disease?

Yes: To get the best use of this site you need to provide background information and ask a specific question. This is not a chat room & each question goes out at random to the site consultants. No questions are linked & we cannot see anything you upload. You are welcome to start over. ...Read more

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How common is celiac disease in children?

How common is celiac disease in children?

Maybe 1% (1 in 100): Celiac disease affects about 1 in 100 people, to about 1 in 150 people. The exact numbers are not certain, but it affects a little less than 1% of the population. ...Read more

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What is a person eat with celiac disease?

What is a person eat with celiac disease?

No wheat rye barley: You can eat meat, chicken, turkey, fish, nuts, fruits and vegetables, grains including rice, and corn. Potato and sweet potato. Avoid any wheat, rye, or barley products or products derived from them. This means avoiding products that contain gluten- the product in wheat rye and barley that causes the body to react adversely in celiac. ...Read more

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Can I diagnose myself for celiac disease?

Can I diagnose  myself for celiac disease?

No: You need blood tests for celiac antibodies and an endoscopy to confirm the diagnosis. However, you can eliminate glutens from your diet and see if that helps. ...Read more

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When does celiac disease generally develop?

When does celiac disease generally develop?

Any age: Alrhough celiac disease can reveal itself when very young with a 'classic group' of symptoms, there are many older adults with celiac disase thar is diagnosed only after a thorough 'workup' of iron deficiency anemia - that may simply have presented as gradual fatigue - erroneously attributed to 'old age' by the patient - and sometimes others too :(. ...Read more

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What are some food options for celiac disease?

What are some food options for celiac disease?

Read labels: This requires that you go on a gluten free diet. Gluten is found primarily in wheat, barley and rye, so any product with these is out. There are a number of sources on the web, including the Mayo clinic, that provide guidance.Just search for "gluten free diet".The FDA requires that vendors list any of the top 8 food allergens on packages, so start looking.Some even have a GF seal. ...Read more

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Help please! is celiac disease autosomal or sex-linked?

Help please! is celiac disease autosomal or sex-linked?

Celiac Disease: Celiac disease (cd) may have a higher prevalence in females but sex-linked genetic transmission has not been determined. The immune response genes are autosomal and there has been some linkage with certain genetic alleles hla-dq2 & dq8. If you do not have these alleles you will probably not get cd, but not everyone with these immune responce genes has cd. 30% of caucasions have dq2. ...Read more

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Can i tell me how i can tell people I have celiac disease?

Can i tell me how i can tell people I have celiac disease?

As needed: Using your dominant language works well. You do not need to broadcast the issue in most settings. Your close circle of friends can simply be told you have a food allergy & cannot tolerate gluten/wheat. It is unrealistic to expect them to remove all gluten containing material from social settings, too hard. If they question more, educate them, otherwise keep it simple. ...Read more

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How do you know if you have celiac disease? What are obvious signs?

How do you know if you have celiac disease? What are obvious signs?

No absolute signs: There are some symptoms of celiac that can suggest it enough to start a work-up. The most common ones that i see are: bloating, diarrhea, weight loss, anemia. ...Read more

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What is the full definition of celiac disease? Who was it discovered by?

What is the full definition of celiac disease? Who was it discovered by?

Celiac Disease: First described by Samuel Gee in 1888 in a report entitled "On the Coeliac Affection." Common features include villous atrophy; malabsorption (steatorrhea, weight loss, or other signs of nutrient or vitamin deficiency); and resolution of the mucosal lesions and symptoms upon withdrawal of gluten-containing foods, usually within a few weeks to months. ...Read more

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Is celiac disease hereditary? I have it, but nobody else in my family does.

Is celiac disease hereditary? I have it, but nobody else in my family does.

Celiac is hereditary: The celiac disease genes hla-dq2 or hla-dq8 are hereditary and are in almost all celiac patients. The genetics of the remaining small fraction of patients has not been figured out yet. Two parents could each have only one dq2 or dq8 gene, and have very mild symptoms, but their child could have inherited both the dq2 and dq8 from his parents. The child then gets a full-blown case of celiac disease. ...Read more

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I think i might have celiac disease. What would I have to do to find out for sure?

I think i might have celiac disease. What would I have to do to find out for sure?

Celiac: A blood test can guide your doctor in the diagnosis, the ultimate proof is a biopsy of your intestinal lining. ...Read more

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What is the official definition of celiac disease and what is the range of symptoms?

What is the official definition of celiac disease and what is the range of symptoms?

Celiac disease: Also called gluten intolerance or gluten-sensitive enteropathy is a disease in which the villi of the small intertines are damaged by an abnormal immune response to a grain protein (gluten) present in wheat, rye, barley and oats. Damage to villi results in malabsorbtion of nutrients and result in belly pain, vomiting, constipation, diarrhea, wgt. Loss, poor growth, dermatitis herpetiformis & more. ...Read more

Dr. John Chiu
619 doctors shared insights

Celiac Disease (Definition)

An immune reaction to eating gluten, a protein found in ...Read more