Doctor insights on:
Hla Typing For Celiac Disease
My 34 yr old sister had an hla typing for celiac disease and came back positive for hla dq2.Should she be concerened? Is this something serious?
In Celiac disease the body reacts to gluten (in wheat and gluten like proteins in rye and barley) in the small intestine causing damage. This limits the intestine's ability to absorb some nutrients. Classically people have loose stool, bloating, and abdominal discomfort but more often are just found when screened for other reasons (like symptoms of a nutritional deficiency like ...Read more
Lower abdominal discomfort, ultra/ct scans, bloodwork, esr, pst, colonoscopy, celiac hla typing, celiac panel all normal. Can it be ativan withdrawal?
It is nonspecific sy: Your symptoms are not anything serious to justify anymore testing, as you already have done a lot. I would hold off any further interventions and eat and live normally. Begin to exercise daily would help to get your mind of this vague symptom of abdominal discomfort. ...Read more
HLA typing: Describes the determination of proteins on the cell surface which the immune system utilizes to assign self and not self. There are multiple genes which encode these proteins on chromosome 6. ...Read more
Donor-Recipient: These are all methods of determining compatibility between donor and recipient with organ and tissue transplants. Everyone has certain protein and carbohydrate markers on the outside of every cell. These make us unique, but also are potential allergens between people. To help prevent rejection (which can be life-threatening) we try to make sure the markers are alike as possible in both people. ...Read moreSee 1 more doctor answer
In the arena of stem: Cell transplantation this is more defined than in the past. Class one match (hla a, b and c) and class two (hla dr and dq) are all performed at high resolution (gene level tryping). The best match with all loci evaluated will produce the lowest chance of graft rejection. Mis-match can be assessed in the gvhd and host vs graft (rejection) direction. ...Read more
Genetics: If you are born with genetic mutations, hla types dq2 or dq8, this predisposes you to develop celiac disease. Then it is usually an environmental trigger, like abnormal gut microbes or infection that triggers it from being a genetic predisposition into an active condition. The condition starts with damage the the microvilli that line the gut and eventually ends with total villous atrophy. ...Read more
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