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Doctor insights on: Hla B27

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Dr. Krishna Kumar
59 doctors shared insights

Hla B27 (Overview)

Hla = human leukocyte antigen. Important in recognition of self and not self. Different proteins (antigens) for different people. B is one of the loci, and hlab27 has been associated with predisposition to immunologic rheumatologic diseases, especially ankylosing spondylitis.


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What is the link between hla-b27 in blood &severe back&throat pain?Pl.Suggest remedy.

What is the link between hla-b27 in blood &severe back&throat pain?Pl.Suggest remedy.

See details: This gene is linked to several arthritic disorders, including ankylosing spondylitis. The throat pain may be related to inflammation of the crycoarytenoid joint. See a rheumatologist if possible. There are several good treatment options. ...Read more

Dr. Krishna Kumar
59 doctors shared insights

Hla B27 (Overview)

Hla = human leukocyte antigen. Important in recognition of self and not self. Different proteins (antigens) for different people. B is one of the loci, and hlab27 has been associated with predisposition to immunologic rheumatologic diseases, especially ankylosing spondylitis.


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Is hla b27 testing a very common procedure?

Is hla b27 testing a very common procedure?

Yes: There are several labs which run this test. It looks for a protein on the surface of your white blood cells. ...Read more

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What autoimmune diseases may cause raised ALT, ankle pain, chest pain, spine & shoulder pain without ANA, HLA B27 being positive?

What autoimmune diseases may cause raised  ALT, ankle pain, chest pain, spine & shoulder pain without ANA, HLA B27 being positive?

Not many: Sounds like you have already had a "work-up" for your symptoms (ANA. HLA B27 are not :common" tests The raised ALT may or may not be associated with your other symptoms. Do you have a liver problem? Hepatitis B, C often cause associated joint problems. Get this checked out by the same Health Care Provider who obtained the blood tests you mention Hope this helps Dr Z ...Read more

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What does it mean if i'm hla-b27 positive? I have severe hip pain- does it have to do with this?

What does it mean if i'm hla-b27 positive? I have severe hip pain- does it have to do with this?

Susceptibility to: Some disorders. People who have the hla b-27 antigen are more prone to some diseases, e.G, ankylosing spondylitis. It does not mean the person has it, just that person is more likely to have some inflammatory disorders, including inflammation of joints. ...Read more

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Positive for hla-b27.This procedure rules out the b27:06 & 27:09 alleles which lit suggests arent associated w/ spondyloarthropathies.What this mean?

Positive for hla-b27.This procedure rules out the b27:06 & 27:09 alleles which lit suggests arent associated w/ spondyloarthropathies.What this mean?

Spondyloarthritis: Hlab27 is a generic marker that is in 8% of the caucasian population. Many people with diseased called spondyloarthropathies (ankylosing spondylitis, psoriatic arthritis, and crohns/uc related arthritis) will have a positive b27, but not all those with b27 will develop issues (in fact, the vast majority don't). The larger question is are the symptoms consistent with spondyloarthropathy. ...Read more

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What do you think if a person has a consistently high C4 complement? Ccp, ana+, hla b27+ (no inflammatory arthritis). Occasional elevated cr; fatigue

What do you think if a person has a consistently high C4 complement? Ccp, ana+, hla b27+ (no inflammatory arthritis). Occasional elevated cr; fatigue

Not to worry: Thee is no disease associated with a high c4. Patients with active lupus may have a low c4. Your other results are confusing. Sounds like you need a rheumatologist to do a complete history and physical exam and to interpret the results of the lab studies. ...Read more

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Hla b27+ and osteoporosis, bone pain, next hi in urine, -ca, na, creatinine, oxalate, citrate, volume.Cerum ca and pth normal. What is the problem & condition?

Hla b27+ and osteoporosis, bone pain, next hi in urine, -ca, na, creatinine, oxalate, citrate, volume.Cerum ca and pth normal. What is the problem & condition?

Not sure: Cannot diagnose you with this information. Consider seeing a bone specialist. But for osteoporosis in general, check vit d levels, and rbc magnesium. Supplement with strontium, boron, d, and magnesium. Cut back any alcohol use. ...Read more

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Hla b27 is itcurable or not ?

Hla b27 is itcurable or not ?

Not needed: It requires no cure. Hla-b27 is a marker protein present in patients with certain diseases but it is also present in healthy individuals. Having a positive hla-b27 does not diagnose any disease. It should only be run in cases where there is suspicion of a particular disease in which case it can assist in making a diagnosis. ...Read more

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