Doctor insights on:
Histone H3 Total
In addition to the low immunoglobulins, I have positive histone ab of 5.6 range 1 and up being positive. Is there a possible connection of the two?
No: But you need to see an allergist/immunologist and/or rheumatolgist (the latter if you have joint symptoms). ...Read more
???: I am not sure about a correlation with blood worm and this antibody? Anti-histone antibodies are autoantibodies that are found in 50%-70% of patients with systemic lupus erythematosus (sle), but I am unawre of a correlation with blood worms? Posibly a pathologist may know of a correlation. ...Read more
I have dual pattern speckled centro mere, low positive ana. High availability, positive IgG histone. What does this indicative?
Rx person, not labs: The anti-nuclear antibody test is one of the most difficult for a commercial lab to perform, and I've learned to distrust results. If you have crest clinically, i'd consider this supported by your labs; if you have drug-induced lupus clinically, ditto. Ultimately, the diagnosis and the decision to treat or not will be made by your rheumatologist in collaboration with you. ...Read more
Fertility specialist: Immunological evaluation for infertility is nonstandard but done by some fertility specialist. Most specialist do not do these test as standard testing as the results may or may not be reliable. Each positive case must be analyzed individually. Schedule follow up with the ordering physician to determine the next steps in your treatment and evaluation. ...Read more
1/80 + ana, dual pattern, speckled, centro mere. High aca centromere. High histone ab, igg. See sxs list. Recommendations? Other blood tests -.
Results meaningless: That's right, lab results are meaningless without a history of symptoms, past medical history, family history of related illnesses, previous laboratory tests & your response to medication so far. Without this other information one can only guess at a way to help you. You should be under the care of an experienced rheumatologist. Your primary care provider of local medical society can recommend one. ...Read more
Blood work results: "elevated rheumatoid factor & ccp c/w ra; elevated jo 1 (34h) & anti histone (1.2h) antibodies, mng" what should this mean to me?
Do anti-histone antibodies appear exclusively in drug-induced lupus or can they appear in SLE & other disorders as well?
SLE: These antibodies are more common in drug induced lupus but occur in garden variety SLE as well. ...Read more
SM 5 RNP 9 SSA 14 SSB 7 SCL-70 10 JO-1 7 Histone 3 Centromere 3 CCP 1 ANA 1:320 DNA neg. Do these blood tests indicate lupus?
+ ANA: This may indicate Lupus, you need to f/u with your Rheumatologist to get a complete explanation of all of your results. It looks like you definitely have some kind of autoimmune disorder. Are you having any kind of pain in your joints? What is your RA factor? Let your Dr. Know about this. Good Luck ...Read more
Can lisinopril cause DISLE lupus? Have anti histone antibodies 1.4 and suffered AKI. Symptoms improved after disc lisinopril and with low dose pred.
+ANA test. Elevated histones AB only. Only on aspirin and BB. Take some supplements in low doses like serrapeptase. Can this cause drug induced lupus?
Not known: I am not aware that this is associated with drug-induced lupus. Antihistone anybody's can be seen in wild or systemic lupus as well as drug-induced lupus. Certainly there is no evidence from what you tell us that you have lupus of any type. You say you're on aspirin and I'm uncertain why and you say are on BB and I don't know what that is. From the information you're giving us I'm not certain the information you're giving us I'm not even certain why they did it in a testing on you. From what I can tell you don't have Lucas from this conversation ...Read more
Low positive ana, dual pattern speckled, centromere. Positive aca and positive histone ab igg. After c/o skin rash and moderate right hip pain.
Need to be evaluated: A low titer (concentration) ANA test is not particularly helpful to make a diagnosis. Even with a particular pattern (speckled) and anti-centromere antibodies and anti-histone antibodies. Your rash and hip pain are more important as well as inflammatory markers like an ESR and a CBC if they are normal or not. See your doctor and ask for a referral to a rheumatologist if you are concerned. ...Read more
7yrs on prednisone & methotrexate + for "resistant ra" recent elevated jo1, histone, muscle pain. How to confirm if polymyositis w/o stopping meds?
Mucle testing: Inflammatory myopathy, including polymyositis, is best diagnosed and treated by a trained rheumatologist. Symptoms are proximal muscle weakness. Abnormal lab tests include elevated muscle enzymes (CPK, AST/ALT); positive antibody tests, including Jo-1; abnormal EMG/nerve conduction test; edema seen on an MRI of proximal muscles; muscle biopsy showing destruction and regeneration of muscle cells. ...Read more
I have positive ana, positive anti-centromere & anti-histone ab igg. R hip, b shoulder pain. Rash, sleep disturbance, sob. What should I do next?
See a rheumatologist: Have a rheumatologist evaluate the issues, . ...Read more
Presented w/ inability to walk, joint/muscle pain, hairloss, positive ana, high ssdna, dsdna, ssa (ro), histone, sed rate, could this be lupus?
Yes: It certainly could be lupus. See a rheumatologist as soon as possible. ...Read more
Presented w/ inability to walk, hair loss, muscle/joint pain, have a positive ana, high levels of ssdna, dsdna, ssa (ro), histone, sed rate. Lupus?
Could be: You need a good work-up with a qualified rheumatologist -- soon? ...Read more
Probably, however...: Omega h3 looks like a decent multivitamin that has some fish oil in it as well. It looks like it's safe to take in pregnancy. My 2 concerns- it does not say that the cod liver oil is purified, which is ideal or it's likely to contain toxins. It has synthetic Folic Acid which, taken in the first weeks reduces liklihood of birth defects but is not as good as the active l-5-mthf form. See comment:. ...Read more