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Doctor insights on: Histone H3 Total

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What causes elevated histone antibody levels in bloodworm?

What causes elevated histone antibody levels in bloodworm?

???: I am not sure about a correlation with blood worm and this antibody? Anti-histone antibodies are autoantibodies that are found in 50%-70% of patients with systemic lupus erythematosus (sle), but I am unawre of a correlation with blood worms? Posibly a pathologist may know of a correlation. ...Read more

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I have dual pattern speckled centro mere, low positive ana. High availability, positive IgG histone. What does this indicative?

I have dual pattern speckled centro mere, low positive ana. High availability, positive IgG histone. What does this indicative?

Rx person, not labs: The anti-nuclear antibody test is one of the most difficult for a commercial lab to perform, and I've learned to distrust results. If you have crest clinically, i'd consider this supported by your labs; if you have drug-induced lupus clinically, ditto. Ultimately, the diagnosis and the decision to treat or not will be made by your rheumatologist in collaboration with you. ...Read more

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Doctor did lab work, did a histone about test came back positive. What does this test indicate?

Doctor did lab work, did a histone about test came back positive. What does this test indicate?

This: This antibody can be seen in systemic and drug-induced lupus. It is up to your rheumatologist to interpret this test result in the context of your symptoms and the rest of your lab results. ...Read more

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Treatment for high anti histone in immunological work up before pregnancy?

Treatment for high anti histone in immunological work up before pregnancy?

Fertility specialist: Immunological evaluation for infertility is nonstandard but done by some fertility specialist. Most specialist do not do these test as standard testing as the results may or may not be reliable. Each positive case must be analyzed individually. Schedule follow up with the ordering physician to determine the next steps in your treatment and evaluation. ...Read more

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+ana 1280. Dsdna 23 iu/ml (<40 is neg), other ENA neg. Not yet tested for histone. Have some symptoms. Is dsdna significant here? Developing sle?

No: Many patients with lupus only have a positive ANA with all other autoantibodies being negative. If the dna was positive, it is more specific for lupus than the ana. The histone is less valuable unless you are screening for a drug induced lupus. ...Read more

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1/80 + ana, dual pattern, speckled, centro mere. High aca centromere. High histone ab, igg. See sxs list. Recommendations? Other blood tests -.

1/80 + ana, dual pattern, speckled, centro mere. High aca centromere. High histone ab, igg. See sxs list. Recommendations? Other blood tests -.

Results meaningless: That's right, lab results are meaningless without a history of symptoms, past medical history, family history of related illnesses, previous laboratory tests & your response to medication so far. Without this other information one can only guess at a way to help you. You should be under the care of an experienced rheumatologist. Your primary care provider of local medical society can recommend one. ...Read more

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Blood work results: "elevated rheumatoid factor & ccp c/w ra; elevated jo 1 (34h) & anti histone (1.2h) antibodies, mng" what should this mean to me?

Blood work results: "elevated rheumatoid factor & ccp c/w ra; elevated jo 1 (34h) & anti histone (1.2h) antibodies, mng" what should this mean to me?

See a rheumatologist: The rf and ccp would suggest RA strongly: the jo-1 can go along with polymyositis, but your rheumatologist would need to see if they thought you have that. ...Read more

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SM 5 RNP 9 SSA 14 SSB 7 SCL-70 10 JO-1 7 Histone 3 Centromere 3 CCP 1 ANA 1:320 DNA neg. Do these blood tests indicate lupus?

+ ANA: This may indicate Lupus, you need to f/u with your Rheumatologist to get a complete explanation of all of your results. It looks like you definitely have some kind of autoimmune disorder. Are you having any kind of pain in your joints? What is your RA factor? Let your Dr. Know about this. Good Luck ...Read more

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Can lisinopril cause DISLE lupus? Have anti histone antibodies 1.4 and suffered AKI. Symptoms improved after disc lisinopril and with low dose pred.

Can lisinopril cause DISLE lupus? Have anti histone antibodies 1.4 and suffered AKI. Symptoms improved after disc lisinopril and with low dose pred.

Yes: Studies show that lisinopril can cause drug induced Systemic Lupus Erythematosus. These studies also show that drug induced lupus caused by lisinopril is sometimes ANA negative. Good luck.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/11780682 ...Read more

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+ANA test. Elevated histones AB only. Only on aspirin and BB. Take some supplements in low doses like serrapeptase. Can this cause drug induced lupus?

+ANA test. Elevated histones AB only. Only on aspirin and BB. Take some supplements in low doses like serrapeptase. Can this cause drug induced lupus?

Not known: I am not aware that this is associated with drug-induced lupus. Antihistone anybody's can be seen in wild or systemic lupus as well as drug-induced lupus. Certainly there is no evidence from what you tell us that you have lupus of any type. You say you're on aspirin and I'm uncertain why and you say are on BB and I don't know what that is. From the information you're giving us I'm not certain the information you're giving us I'm not even certain why they did it in a testing on you. From what I can tell you don't have Lucas from this conversation ...Read more

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Low positive ana, dual pattern speckled, centromere. Positive aca and positive histone ab igg. After c/o skin rash and moderate right hip pain.

Low positive ana, dual pattern speckled, centromere. Positive aca and positive histone ab igg. After c/o skin rash and moderate right hip pain.

Need to be evaluated: A low titer (concentration) ANA test is not particularly helpful to make a diagnosis. Even with a particular pattern (speckled) and anti-centromere antibodies and anti-histone antibodies. Your rash and hip pain are more important as well as inflammatory markers like an ESR and a CBC if they are normal or not. See your doctor and ask for a referral to a rheumatologist if you are concerned. ...Read more

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7yrs on prednisone & methotrexate + for "resistant ra" recent elevated jo1, histone, muscle pain. How to confirm if polymyositis w/o stopping meds?

7yrs on prednisone & methotrexate + for "resistant ra" recent elevated jo1, histone, muscle pain. How to confirm if polymyositis w/o stopping meds?

Mucle testing: Inflammatory myopathy, including polymyositis, is best diagnosed and treated by a trained rheumatologist. Symptoms are proximal muscle weakness. Abnormal lab tests include elevated muscle enzymes (CPK, AST/ALT); positive antibody tests, including Jo-1; abnormal EMG/nerve conduction test; edema seen on an MRI of proximal muscles; muscle biopsy showing destruction and regeneration of muscle cells. ...Read more

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Please is it safe to take omega h3 in pregnancy?

Please is it safe to take omega h3 in pregnancy?

Probably, however...: Omega h3 looks like a decent multivitamin that has some fish oil in it as well. It looks like it's safe to take in pregnancy. My 2 concerns- it does not say that the cod liver oil is purified, which is ideal or it's likely to contain toxins. It has synthetic Folic Acid which, taken in the first weeks reduces liklihood of birth defects but is not as good as the active l-5-mthf form. See comment:. ...Read more