Top
30
Doctor insights on: Histamine H1 Antagonists

Share
1

1
Why second generation histamine h1 antagonist are the drug of choice in treatment of chronic allergy? Explain please!

Why second generation histamine h1 antagonist are the drug of choice in treatment of chronic allergy? Explain please!

Best allergy medicin: Second generation antihistamines generally have fewer side effects (ie. Sedation and dryness), longer durations of action, and little tachyphlaxis (loose effectiveness with use) than older antihistamines. However for chronic nasal allergies, evidence based medicine places topical nasal steroid sprays as first line therapy ahead of antihistamines, oral or topical. ...Read more

Histamine (Definition)

Histamine is an organic nitrogen compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine triggers the inflammatory response. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found ...Read more


2

2
Which is the most potent histamine h1 receptor blocker that causes serious sedation?

Which is the most potent histamine h1 receptor blocker that causes serious sedation?

Too many to list: There are truly dozens of h1 receptor blockers, many of the first generation of which will result in sleepiness. The tow most commonly used to treat insomina (which would result in sleeping) are Diphenhydramine and doxylamine. ...Read more

3

3
What is the function of histamine?

What is the function of histamine?

Histamine : Is a complex organic substance, it is a neurotransmitter and has got several physiologic functions,:in immune system, gastrointestinal tract and nervous system, you can browse the internet for various sources of information on the subject ...Read more

4

4
What are the effects of histamine usually?

What are the effects of histamine usually?

Lots of effects: Histamine is a chemical that is ordinarily present in different types of cells in the body. It has multiple effects on blood vessels, glands and nerves and the symptoms depend on whether the histamine is released locally or throughout the body. In the nose, causes sneezing, itching and runny nose. In the skin causes swelling and itching and redness. ...Read more

5

5
Does chantix release histamine?

Not that I know of: it acts on nicotine subreceptors (alpha2beta4 as I remember), and does not release histamine. I see you have a mast cell disorder, so you should be running this by the allerist/immunologist or rheumatologist you are seeing for that condition. ...Read more

6

6
Is histamine excitatory or inhibitory?

Excitatory: Histamine is actually classified as an excitatory neurotransmitter in the brain responsible for the sleep wake cycle. Too much of it can keep you awake. That is why it is used in many commercial sleep aides seen with the letters "pm" attached to some kind of pain killer. A common side-effect of a histamine blocker like Diphenhydramine (benadryl) is drowsiness. ...Read more

7

7
Does excitement cause histamine release?

Does excitement cause histamine release?

Not usually, but....: The field of psychoneuroimmunology taught us that our immune response can be activated by suggestion -- for example, developing some allergy symptoms when seeing just a picture of a cat (for someone with a severe allergy to cat dander). Typically, histamine is released by mast cells in the presence of antigen-antibody complexes containing antigens interpreted by the immune system as foreign. ...Read more

8

8
How many anti histamines can you take daily?

How many anti histamines can you take daily?

Diphenhydramine: 300 mg/day from all sources, 50 mg in one dose q 6 hours, it is the most widely used OTC. Other OTC 2nd generation antihistamines as cetirizine , loratadine or fexofenadine have different dosing but can be taken once a day, and do not develop tolerance, as the case with diphenhydramine, with prolonged usage. Don't combine different types unless you ask a physician, wish you wellness ...Read more

9

9
What is the proper dosage of anti-histamine?

What is the proper dosage of anti-histamine?

Package instructions: The package instructions will give the recommended dosages for over the counter medication. Prescriptions will give the proper dosing of antihistamines and other medications. Usual dosing takes into account other medications you might be taking plus a margin of safety. When in doubt, ask your physician. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
11

11
What are the common effective anti-histamines?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What are the common effective anti-histamines?

Anti-histamines: They can be h1-receptor antagonists such as Benadryl (diphenhydramine) or periactin or loratadine. Or, h2-receptor antagonists such as tagamet or ranitidine. Or, h3/h4 receptor antagonists (experimental) such as thioperamide. Or, atypical antihistamines such as catechin. Or, others such as cromolyn. ...Read more

12

12
Overdosing on anti histamine tablets bad for you?

Yes: Overdosing on anything is bad for you. Although these drugs are safe, you must be cautious in taking them. ...Read more

13

13
How much anti-histamine meds could cause overdose?

It depends: There are several formulations out and each is unique. Luckily, these are relatively safe drugs. Treat them with respect! ...Read more

14

14
What dosage does someone overdose on anti-histamines?

What dosage does someone overdose on anti-histamines?

Depending: ...On the antihistamine in Question, do not use more than the recommended doses on the package unless instructed by your physician ...Read more

15
16

16
Can a child of nine years take a anti histamine pills?

Some can, some won't: I have had 2 yo kids develop the skill needed to handle taking a pill or tablet. Whether it is the proper dose at that age would depend on the medication. ...Read more

17

17
I think I have histamine intolerance, what should I do?

More info: Please explain what it is that bothers you. Histamine is a chemical that causes allergic symptoms in every body, so that taking meds as suggested may be helpful. To be able to give you a better answer, you need to describe exactly what happens to y ou. ...Read more

18

18
Can a child of nine years take an anti histamine pills?

Can a child of nine years take an anti histamine pills?

Yes, if healthy: Antihistamines are available in pills, chewable tablets or liquid and can be safely taken by children of almost any age. Doses are not well defined in children less than 2 yrs of age. ...Read more

19

19
Is eosinophilia associated with the release of histamine? Please advise!

Yes, Sometimes: Elevated eosinophils can be the end result of chronic histamine release because when histamine is released other immune system messengers are also released that cause eosinophils to migrate into the tissue. That said, antihistamines will not lower eosinophil counts. If your eosinophils are consistently high, you may need steroids or further evaluation and testing to determine the cause. ...Read more

20

20
I have histamine intolerance. Other than low histamine diets, what else can I do to help myself?

I have histamine intolerance. Other than low histamine diets, what else can I do to help myself?

Histamine Intoleranc: In addition to diet control, you could try diamine oxidase formula that works in the gut to degrade histamine from ingested food. Dosing: or optimal results, usually prescribed as to take one (1) or two (2) capsules no more than 15 minutes before the consumption of histamine-rich foods or substances known to cause food intolerance; or take as directed by your healthcare practitioner. ...Read more

24

24
I have an allergy seems like histamine?

I have an allergy  seems like histamine?

Allergies: Most allergic responses create a release of histamine from mast cells in the body. These chemicals like histamine affect your body to create the allergy symptoms people feel. That is why you take antihistamines. ...Read more

25

25
Does lisinopril have histamines in it?

Does lisinopril have histamines in it?

No but: It doesn't have histamine but it can cause a histamine like reaction with angioedema, cough, and upper respiratory tract irritation. It does this through a different (not histamine related) mechanism. ...Read more

26

26
If you combined h1 and h2 anti-histamines, could this prevent anaphylaxis?

If you combined h1 and h2 anti-histamines, could this prevent anaphylaxis?

Not necessarily: H1 and h2 antihistamines are used for the treatment of anaphylaxis in addition to Epinephrine and steroids. Preventing anaphylaxis is challenging--best way is to avoid the trigger. In those cases where no trigger is found and anaphylaxis is occurring frequently, Prednisone (steroids) will be used on a daily basis. This carries a high risk of side effects however. ...Read more

27

27
How does histamine affect you health?

Excesss causes sympt: Histamine is a normal chemical in your body and is involved in normal processes that regulate blood vessel, stomach acid and nervous system processes. Excessive amounts of histamine can cause symptoms similar to allergies. ...Read more

28

28
How do you get high histamine levels?

High histamine: Typically you get this when you have an allergic reaction. It is a substance released by mast cells in your body, causing all the symptoms of an allergy. ...Read more

29

29
How do you get handle high histamine levels?

Block and Lower: Besides the conventional approach to block histamine receptors with agents like benadryl, (diphenhydramine) i also like to use agents that naturally lower the white cells production of histamine. These include: quercetin, stinging nettles leaf, bromelain, and n-acetyl cysteine (nac) a natural substance use in emergency rooms for asthmatics. ...Read more

30

30
How can I find out if I am histamine intolerant?

Food trials.: Try trial of foods low in histamine. Keep food log and monitor symptoms. Then trial foods high in histamine and continue log. If you find there is an association you may have histamine intolerance. I am not sure the medical community agrees on the existence of histamine intolerance.

http://www.allergyuk.org/common-food-intolerances/histamine-intolerance. ...Read more