Doctor insights on:
Histamine H1 Antagonists
Why second generation histamine h1 antagonist are the drug of choice in treatment of chronic allergy? Explain please!
Best allergy medicin: Second generation antihistamines generally have fewer side effects (ie. Sedation and dryness), longer durations of action, and little tachyphlaxis (loose effectiveness with use) than older antihistamines. However for chronic nasal allergies, evidence based medicine places topical nasal steroid sprays as first line therapy ahead of antihistamines, oral or topical. ...Read more
Histamine is an organic nitrogen compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine triggers the inflammatory response. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found ...Read more
Histamine : Is a complex organic substance, it is a neurotransmitter and has got several physiologic functions,:in immune system, gastrointestinal tract and nervous system, you can browse the internet for various sources of information on the subject ...Read more
Lots of effects: Histamine is a chemical that is ordinarily present in different types of cells in the body. It has multiple effects on blood vessels, glands and nerves and the symptoms depend on whether the histamine is released locally or throughout the body. In the nose, causes sneezing, itching and runny nose. In the skin causes swelling and itching and redness. ...Read more
Excitatory: Histamine is actually classified as an excitatory neurotransmitter in the brain responsible for the sleep wake cycle. Too much of it can keep you awake. That is why it is used in many commercial sleep aides seen with the letters "pm" attached to some kind of pain killer. A common side-effect of a histamine blocker like Diphenhydramine (benadryl) is drowsiness. ...Read more
Not usually, but....: The field of psychoneuroimmunology taught us that our immune response can be activated by suggestion -- for example, developing some allergy symptoms when seeing just a picture of a cat (for someone with a severe allergy to cat dander). Typically, histamine is released by mast cells in the presence of antigen-antibody complexes containing antigens interpreted by the immune system as foreign. ...Read more
Diphenhydramine: 300 mg/day from all sources, 50 mg in one dose q 6 hours, it is the most widely used OTC. Other OTC 2nd generation antihistamines as cetirizine , loratadine or fexofenadine have different dosing but can be taken once a day, and do not develop tolerance, as the case with diphenhydramine, with prolonged usage. Don't combine different types unless you ask a physician, wish you wellness ...Read more
Package instructions: The package instructions will give the recommended dosages for over the counter medication. Prescriptions will give the proper dosing of antihistamines and other medications. Usual dosing takes into account other medications you might be taking plus a margin of safety. When in doubt, ask your physician. ...Read more
Anti-histamines: They can be h1-receptor antagonists such as Benadryl (diphenhydramine) or periactin or loratadine. Or, h2-receptor antagonists such as tagamet or ranitidine. Or, h3/h4 receptor antagonists (experimental) such as thioperamide. Or, atypical antihistamines such as catechin. Or, others such as cromolyn. ...Read more
It depends: There are several formulations out and each is unique. Luckily, these are relatively safe drugs. Treat them with respect! ...Read more
Some can, some won't: I have had 2 yo kids develop the skill needed to handle taking a pill or tablet. Whether it is the proper dose at that age would depend on the medication. ...Read more
Yes, Sometimes: Elevated eosinophils can be the end result of chronic histamine release because when histamine is released other immune system messengers are also released that cause eosinophils to migrate into the tissue. That said, antihistamines will not lower eosinophil counts. If your eosinophils are consistently high, you may need steroids or further evaluation and testing to determine the cause. ...Read more
Histamine Intoleranc: In addition to diet control, you could try diamine oxidase formula that works in the gut to degrade histamine from ingested food. Dosing: or optimal results, usually prescribed as to take one (1) or two (2) capsules no more than 15 minutes before the consumption of histamine-rich foods or substances known to cause food intolerance; or take as directed by your healthcare practitioner. ...Read more
If I am histamine intolerant, what foods should I avoid and what foods can I eat? I need data, the internet has conflicting answers.
Histamine intolerant: I would make an appointment with an allergist and immunologist. Best of luck. ...Read more
Low-tyramine diet and low histamine-diet where i can find recipes for this diet?I am on medication and i have to avoid tyramine and histamine..
Web MD: Go to Web MD .They should have all your answers ...Read more
Not necessarily: H1 and h2 antihistamines are used for the treatment of anaphylaxis in addition to Epinephrine and steroids. Preventing anaphylaxis is challenging--best way is to avoid the trigger. In those cases where no trigger is found and anaphylaxis is occurring frequently, Prednisone (steroids) will be used on a daily basis. This carries a high risk of side effects however. ...Read more
Block and Lower: Besides the conventional approach to block histamine receptors with agents like benadryl, (diphenhydramine) i also like to use agents that naturally lower the white cells production of histamine. These include: quercetin, stinging nettles leaf, bromelain, and n-acetyl cysteine (nac) a natural substance use in emergency rooms for asthmatics. ...Read more
Try trial of foods low in histamine. Keep food log and monitor symptoms. Then trial foods high in histamine and continue log. If you find there is an association you may have histamine intolerance. I am not sure the medical community agrees on the existence of histamine intolerance.
http://www.allergyuk.org/common-food-intolerances/histamine-intolerance. ...Read more