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Doctor insights on: High T3 Low T4

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Dr. Jesse Krakauer
460 Doctors shared insights

Liothyronine (Definition)

Liothyronine is a thyroid agent. ...Read more


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High T4 and low T3 (liothyronine) after complete thyroidectomy. Currently take 200mcg of levethyroxine. Should I increase or cut my dose?

High T4 and low T3 (liothyronine) after complete thyroidectomy. Currently take 200mcg of levethyroxine. Should I increase or cut my dose?

Depends: Levothyroxine is t4. T4 is converted to t3 (liothyronine), (liothyronine) the active thyroid hormone. Some patients have trouble converting T4 to t3 (liothyronine) and need t3 (liothyronine) replacement inaddition to T4 replacement. You should talk to your doctor about your levels. Depending on the reason for your thyroidectomy, like thyroid cancer, you may want to have higher T4 levels to suppress your tsh. ...Read more

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My T3 levels have been low consistently, TSH normal, T4 on the high end of normal. Is the low T3 anything to be concerned about?

Hypothyroid and T3: If the TSH is normal, then that is strong evidence that you are normal. Pituitary TSH responds mostly to T3. If you T3 were too low, the TSH should be high. Indeed, I am not sure why T3 is being measured. There are more problems with the T3 assay than that of T4. This could just be "lab error". ...Read more

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What does a low normal TSH (1.4) and high T4 (11.1) mean? T3 (liothyronine) is normal.

Subclinical thyroid: Could represent subclinical hyperthyroid or early thyroid disease or lab error. Should monitor this over a period of months to see if there is any change. ...Read more

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I have a low level of t3, (liothyronine) ft3, (liothyronine) t4, and ft4. However I have a high amount of tsh. What does it say?

Hypothyroidism: Ask the doctor who ordered the tests for more details, but I think you need to take thryoid pills. ...Read more

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TSH normal at 1.35 T4 8 (range 10-20) T3 (liothyronine) 5.8 (range 3.2-6.0) what are reasons for low T4 levels when TSH is normal and T3 (liothyronine) high normal?

TSH normal at 1.35 T4 8 (range 10-20) T3 (liothyronine) 5.8 (range 3.2-6.0) what are reasons for low T4 levels when TSH is normal and T3 (liothyronine) high normal?

Hypothyroidism: This likely indicates secondary hypothyroidism, due to problem with your pituitary gland. Normally, if the T4 is low, the pituitary will produce more TSH to try and induce the thyroid glad to produce more T4. However, if there is a problem with the pituitary, then the TSH is either low or normal despite a low T4. Be sure to follow up with the doctor how ordered these tests. ...Read more

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I have recently got very low levels of T3 and T4. My TSH is fine. I gained lot of weight and had a very high stress. Do I need some treatment now?

I have recently got very low levels of T3 and T4. My TSH is fine. I gained lot of weight and had a very high stress. Do I need some treatment now?

Just a thought: But your pituitary may be incapable of increasing the TSH and a "normal" level may actually be due to a lack of proper pituitary function (producing a higher TSH in the fact of low thyroid gland function. I would suggest a PITUITARY evaluation and after that is complete I would treat you with Thyroid replacement therapy!
Hope this helps
Dr Z ...Read more

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MCH slightly elevated at 34 (MCV) normal but on high side is it any relation to low t3 (liothyronine) levels 46? TSH and T4 also low laying but normal range.

Yes: Thyroid T3 (liothyronine) levels affect red cell indices, refer to Dorgalaleh et al article Via web literature which answers your question well. ...Read more

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My TSH is high end of normal at 0.66, free T4 is 1.3 but my free T3 (liothyronine) is low end of normal at 2.7. Why does my TSH not better correlate with free t3/t4?

My TSH is high end of normal at 0.66, free T4 is 1.3 but my free T3 (liothyronine) is low end of normal at 2.7. Why does my TSH not better correlate with free t3/t4?

Hard to say,,: First, the TSH isn't at high normal, more like low normal (0.4-2.5uiu/ml), next is that the ft4 is at a high normal value. The ft3 is around low normal but it has a low half life so that might be why. You've got a history of hashimoto's which leads to hypothyroidism and take synthesis for replacement which can explain these values so it's good to see your doctor for a possible med adjustment. ...Read more

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Tsh is high end of normal at 0.66, free T4 is 1.3 but free T3 (liothyronine) is low end of normal at 2.7. T3 (liothyronine) and T4 down 1 point in 1 month. Felt better before. Why?

Tsh is high end of normal at 0.66, free T4 is 1.3 but free T3 (liothyronine) is low end of normal at 2.7. T3 (liothyronine) and T4 down 1 point in 1 month. Felt better before. Why?

Normal TSH: They key word is "normal". Your TSH is normal, which means your pituitary believes your thyroid hormone levels are normal, and the pituitary is usually right. You list a number of autoimmune rheumatologic disorders. These may be responsible for your symptoms, rather than your thyroid. See your rheumatologist. ...Read more

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Tsh 0.01, T3 (liothyronine) free 4.3, t4. Free 1.8? Tsh low T3 (liothyronine) very slightly elevated T4 high normal? Pcp says nothing is wrong?

It's near average: Although all the numbers are running in the right direction for an activated thyroid (autonomous nodule secreting thyroid hormone is my guess).
In any case, follow up repeats are a good idea for tests that show an abnormality but not a definite nor significant nor consistent one. ...Read more

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Tsh 0.01, T3 (liothyronine) free 4.3, t4. Free 1.8? Tsh low T3 (liothyronine) very slightly elevated T4 high normal? Pcp doesn't think much, repeat in 6 weeks?

Thyroid levels: I think I already answered your question about cause. The elevation in FT4 and FT3 is subtle, depending on the lab just barely at or above the normal range. However the low TSH makes me think it is real. Are you having symptoms (palpitations, heat intolerance, tremor, nervous)? Repeating the labs is a good idea, but I would prob not wait 6 weeks. You may need an Endocrinologist. ...Read more

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My thyroid panel shows low T3 (liothyronine) (29), normal T4 (8.10) and high TSH 3.16. What does this mean

My thyroid panel shows low T3 (liothyronine) (29), normal T4 (8.10) and high TSH 3.16. What does this mean

TSH normal: Your TSH is normal and your thyroid appears to be functioning properly. Ignore the "t3" as it's not a real measurement of T3 (liothyronine) level. ...Read more

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If my TSH and T4 are high and free thyroxine is normal...but T3 (liothyronine) uptake is low, should I take synthroid my dr prescribed?

If my TSH and T4 are high and free thyroxine is normal...but T3 (liothyronine) uptake is low, should I take synthroid my dr prescribed?

Yes: Your tests indicate you have a hypo active thyroid and should take replacement. While you may need to take this treatment for long, you need to get these repeated annually to adjust your meds. ...Read more

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Total thyroidectomy 4 mo ago. High TSH & t4, low t3 (liothyronine). Feeling very hypo. Increases in levothyroxine not helping symptoms. Sliding downhill fast! Help!

Thyroid: Something does not sound right.
A high TSH with a high T4 is very uncommon.
It is possible, but unlikely that your pituitary gland is producing too much TSH.
You need to see your thyroid surgeon or your regular doctor as soon as possible. ...Read more

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What does this mean? T3 (liothyronine) free normal, TSH normal, T4 categories-t4 high, t3u low, fti high. Tsh tested again 6 months later, lower but normal. On nuvaring only

What does this mean? T3 (liothyronine) free normal, TSH normal, T4 categories-t4 high, t3u low, fti high. Tsh tested again 6 months later, lower but normal. On nuvaring only

Normal thyroid tests: Normal TSH level indicates normal thyroid function in the majority of cases. Normal free t3 (liothyronine) and normal freet4 usually support the fact. Total T4 (t4) can be high without excess thyroid when the thyroxine binding globulin (tbg), a thyroid hormone carrier, is elevated, as in pregnancy and while taking a bcp. Then t3 (liothyronine) (resin) uptake (t3 (liothyronine)u) is low and fti normal (tests now outdated should not be checked. ...Read more

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TSH normal Range (1.26) T4 Free normal range (1.22) t3 free low normal range (2.5) T3 Uptake LOW (23) Thyroglobulin Antibody HIGH (1.1)?

TSH normal Range (1.26) T4 Free normal range (1.22) t3 free low normal range (2.5) T3 Uptake LOW (23) Thyroglobulin Antibody HIGH (1.1)?

More info needed: A screening test or on thyroid med? He has a normal TSH and normal free T4, so he is normal or has normal replacement results. The T-3 uptake is irrelevant. Many normal individuals have anti-thyroid antibodies. If his thyroid isn't enlarged or has no nodules, don't worry about it. If you are still concerned ask for a referral to an endocrinologist. ...Read more

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TSH is always very low T3 (liothyronine) is normal high T4 is normal low. **Uptake scan, 5.3, showed hypothyroidism! All other tests Ok Pituitary ok different DX's?

TSH is always very low T3 (liothyronine) is normal high T4 is normal low. **Uptake scan, 5.3, showed hypothyroidism! All other tests Ok Pituitary ok different DX's?

Are you taking: Are you taking something with thyroid hormones in it?
What is your reverse T3 (liothyronine) level?
How did the thyroid scan show hypothyroidism? Do you have symptoms of hypothyroidism or hypothyroidism.
How do you know the pituitary function is normal? ...Read more

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Tsh 0.01, T3 (liothyronine) free 4.3, t4. Free 1.8? Tsh low T3 (liothyronine) very slightly elevated T4 high normal? Doctor says could be an error repeat in 5 weeks? Confused?

Tsh 0.01, T3 (liothyronine) free 4.3, t4. Free 1.8? Tsh low T3 (liothyronine) very slightly elevated T4 high normal? Doctor says could be an error repeat in 5 weeks? Confused?

Thyroid: Your labs are confusing because they show a low TSH which is common in hyperthyroidism in conduction with low to normal thyroid hormones. He wants to recheck it to see if he caught it at a transition point or it was a lab error. Hopefully when it is rechecked he will have a better idea of what is going on with your thyroid in conduction with your clinical picture. ...Read more

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Does low TSH mean I have a problem with my pituitary gland? Hypopituitarism? My free T3 (liothyronine) and T4 are high normal???

Low TSH: May reflect Hypopituitary condition if FT4 and FT3 are low also. However if both are high that will indicate Hyperthyroidism. Discuss with your doctor about other modifers like acute illness or medication effects or pregnancy on your thyroid panel result ...Read more

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My 10yr old daughter had lab work completed and the results show a high esr, low tsh, and normal t3/t4. What are possible diagnosis?

My 10yr old daughter had lab work completed and the results show a high esr, low tsh, and normal t3/t4. What are possible diagnosis?

Possibly thyroiditis: The information is incomplete, but subacute thyroiditis (sat), an inflammation of the thyroid gland can cause hyperthyroidism and high esr. People with sat have severe neck pain. With no pain sat is unlikely. A high ESR is found in many non-thyroid conditions: one can have mild hyperthyroidism and another cause for a high esr. Some people with non-thyroid illness have low TSH without being hyper. ...Read more

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I m 66yr my TSH 0.8 ft3 (liothyronine) 4.7 (2-3.6) ft4 0.2 (0.8-1.5) hb 10.2. Have hypoprotinimea, 7 albumin and 3 RBC transfusion in feb. Why low T4 and high t3 (liothyronine).

Medication?: You indicated that you are on thyroxine. I have a feeling that you are taking thyroid medication that contains t3, such as Armour Thyroid or Cytomel (liothyronine). These medications will cause a high t3 and low T4 level, but the TSH will be normal. If the ft3 and ft4 levels were done correctly, they should not have been affected by your low protein problem. ...Read more

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What causes high TSH 7.0 (although normal t3, (liothyronine)t4, pth) and low cortisol (1.0)? I'm being referred to an endo. I'm worried.

What causes high TSH 7.0 (although normal t3, (liothyronine)t4, pth) and low cortisol (1.0)? I'm being referred to an endo. I'm worried.

No worry: In early stages of hypothyroidism TSH is high when T3 (liothyronine) T4 may still be normal. Hypothyroidism is quite common and is easily treatable with an oral medication. However, you must follow your doctor's advice for additional tests and treatments. ...Read more

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Normal range T3/T4 but extremely low TSH (high sensitivity). Slightly low before pregnancy and now extremely low 11 weeks. Endocrine Dr not concerned?

Low TSH: Agree not to worry, your hormone levels are fine and the TSH being slightly is because you are pregnant, just like other things that change with pregnancy.
Don't worry. ...Read more

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Tsh low at. 04, but peroxidase high at 617. Normal free T3 (liothyronine) & t4. Feel awful with hyper symptoms, not hypo. Doc says wait and see. Agree?

Tsh low at. 04, but peroxidase high at 617. Normal free T3 (liothyronine) & t4. Feel awful with hyper symptoms, not hypo. Doc says wait and see. Agree?

Thyroid: If your doc is an endocrinologist, follow his advice. Tsh has an inverse relationship with thyroid activity, i.e. Low tsh=high thyroid activity. The elevated thyroid peroxidase (aka antimicrosomal antibodies) suggests autoimmune hyperthyroid disease, but can also be elevated in other autoimmune disorders like lupus & rheumatoid arthritis & many other conditions. Get 2nd opinion if in doubt. ...Read more

Dr. David Sneid
1,422 Doctors shared insights

Thyroxine (Definition)

Thyroxine is a thyroid agent. ...Read more


Dr. David Geffner
459 Doctors shared insights

T3 (Definition)

T3 is a thyroid agent. ...Read more