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Doctor insights on: High Serum Folate Levels Causes

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My serum folate (folic acid) is 16.4ug/L & B12 is 221ug/L & serum ferritin is 22ug/L. Why is folate (folic acid) on the high end of normal & others on the low end of normal?

My serum folate (folic acid) is 16.4ug/L & B12 is 221ug/L & serum ferritin is 22ug/L. Why is folate (folic acid) on the high end of normal & others on the low end of normal?

Nothing to worry abt: These are all in the normal range, and there is some give and take regarding the laboratory ability to give an exact value. Don't worry about these values unless they are way higher or way lower than normal. ...Read more

Folic Acid (Definition)

Folic acid, AKA folate (folic acid) (vit B9), is recommended for all women wanting to get pregnant -- 0.4mg (400mcg) daily, which is important for preventing birth defects like spina bifida. Women w/ a hx these disorders should take 10x that amt daily -- 4mg (4000mcg) through the 3rd month of pregnancy. It won't affect fertility, chances of conception/twins, or periods. ...Read more


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Hi Docs: If + for 2 MTHFR genes, what are possible effects on body from foods high in folate (folic acid)? And is it typical to have lowish (<6) serum folate (folic acid)?

Hi Docs: If + for 2 MTHFR genes, what are possible effects on body from foods high in folate (folic acid)? And is it typical to have lowish (<6) serum folate (folic acid)?

Need more not less!: If you have a problem with two MTHFR genes, you actually need folic acid supplementation. Foods high in folate will help you not hurt you. I usually recommend 4mg of folic acid a day, along with 1000ug of B-12 and 100mg B-6 per day and a bab aspirin. Some women with the MTHFR defect have repeated miscarriages. In my experience, the above supplements decrease the risk of this. Best wishes! ...Read more

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High albicans, igg, iga, and igm. Serum iron and % sat high, T4 low, and folate (folic acid) low-help where do I start? Have celiac disease.

High albicans, igg, iga, and igm. Serum iron and % sat high, T4 low, and folate (folic acid) low-help where do I start? Have celiac disease.

See a hematologist: If your iron level is high, you need to be bled periodically to prevent damages to your organs particularly your liver. This is a continuing process and not a one-shot deal. As for your thyroid, you need another test to confirm whether your thyroid replacement is adequate. Since natural thyroid extract is not standardized, it is hard to regulate your thyroid with it (used about 50 yrs ago). ...Read more

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Labs: *MILDLY* LOW: RBC, Hgb, Hematocrit. Ferritin/Iron studies are normal. Serum Folate is LOW. Would MCV + RDW have to be HIGH for Folate-Anemia?

Labs: *MILDLY* LOW: RBC, Hgb, Hematocrit. Ferritin/Iron studies are normal. Serum Folate is LOW. Would MCV + RDW have to be HIGH for Folate-Anemia?

Try HealthTap PRIME: Lab results usually are numbers, and numbers are just numbers, with little meaning unless a doctor takes in the whole picture of what's going on with his patient. Getting all the details around a set of numbers is helpful in making interpretations. Try our premium forum, HealthTap PRIME, for a virtual consultation, in which a doctor can ask questions and look over the lab results to explain them. ...Read more

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Serum b12> 1999 mma 0.4, homocysteine high 19. No folate (folic acid) or iron deficiency normocytic anemia not responding to procrit. Is this an absorption issue?

Serum b12> 1999 mma 0.4, homocysteine high 19. No folate (folic acid) or iron deficiency normocytic anemia not responding to procrit. Is this an absorption issue?

Anemia: Can be caused by blood loss or bone marrow suppression as well. More information is needed (how long have you had a normal iron, folate (folic acid) and b12 level. What is your reticulocyte count? (is your bone marrow producing new RBC's)? How low is your HCT and has it come up or gone down with B12. Is the RDW elevated (do you put out large and small RBC's at the same time? Any blood loss? ...Read more

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How fast do folate (folic acid) levels change? Previous deficient, went from 12 to 8 ug/L in a month, does serum folate (folic acid) fluctuate or have any diurnal variations?

How fast do folate (folic acid) levels change? Previous deficient, went from 12 to 8 ug/L in a month, does serum folate (folic acid) fluctuate or have any diurnal variations?

Serum folate (folic acid)...: ...levels, to the best of my knowledge, don't have a diurnal variation. However, since we're measuring serum (as opposed to Red Blood Cell) levels, they can increase fairly quickly with either dietary intake of folate (folic acid) rich foods or supplements. They decrease more slowly if you're becoming depleted. Both of these levels are within normal range. ...Read more

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Hgb 11.0, MCV 77.6, MCH 23.8, mchc 30.6, RDW 17.9, ferritin level 17.2, folate (folic acid) 5.03, iron serum 42, tibc 441, iron saturation 10. What does this mean?

Any symptoms?: Why did your doc order those tests? Are you feeling tired? Do you have really heavy periods? The hemoglobin is a little low, but not severely low. You are a little iron deficient. You may benefit from taking iron and a stool softener if you don't get enough in your diet. But talk to your doc who ordered the tests, they may have more info. ...Read more

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What should I do if my ferritin and iron serum and folate (folic acid) are all low?

What should I do if my ferritin and iron serum and folate (folic acid) are all low?

Iron and folate (folic acid) defi: You have deficiency of both iron and folic acid. Need to see whether you have nutritional issues, like food fads. Iron and Folic Acid are rich in green leafy vegetables, if you avoid them start taking them. Worth to get a nutrition consult a through your pcp. Take iron and Folic Acid supplemets with otc medications/pcp recomm. Do search for proper food choices, rich in iron and folate n internet. ...Read more

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I had some blood done, my B12 results were 572 which was in the standard range, but my folate, (folic acid) serum result was 15.70. Should I be concerned?

See your doctor: To discuss your concerns.
That would be a normal value for an adult in my lab.
Normal range is usually posted as :
•adults: 2-20 ng/ml, or 4.5-45.3 nmol/l
children: 5-21 ng/ml, or 11.3-47.6 nmol/l
•infants: 14-51 ng/ml, or 31.7-115.5 nmol/l
for plasma folate (folic acid) levels. ...Read more

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I had a blood test and folate, (folic acid) serum is 6.8 ng/ml. Is that within normal range? Please advise, thanks

I had a blood test and folate, (folic acid) serum is 6.8 ng/ml. Is that within normal range? Please advise, thanks

Normal: Please see this for more info on the topic.
http://www. Nlm. Nih. Gov/medlineplus/ency/article/003686.htm. ...Read more

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Are my test results in range? Vitamin B-12 558 FOLATE, SERUM 17.8

Yes: Both results are in the normal range. Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco or alcohol in any form. ...Read more

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My serum folate (folic acid) is abnormal is this why im suffering exhaustion and faitness with dizzyiness and memory loss?

My serum folate (folic acid) is abnormal is this why im suffering exhaustion and faitness with dizzyiness and memory loss?

Folate (folic acid) deficiency: Can cause dementia and neuropathy as well as anemia (fatigue). Its easy to correct the deficiency (take 1 mg a day) Make sure B12 blood level is OK (>350.) ...Read more

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Female. Age-38 hb was 4 in may 2012. Now 7.5.Serum folate (folic acid) >40.Tibc-460. Wbc-11100. Problem -pain in lage and breathing problem. What is your suggation.

Female. Age-38 hb was 4 in may 2012. Now 7.5.Serum folate (folic acid) >40.Tibc-460. Wbc-11100. Problem -pain in lage and breathing problem. What is your suggation.

I assume you meant: Legs, not lage. A hb 4, not good. Even 7.5 is still low. She still needs to be on iron replacement and the source of blood loss remedied. She is likely short of breath because of decreased ability to carry oxygen, same with the legs. If still symptomatic you could consider a transfusion, even 1 unit would help. Needs to be at 9 or 10 for symptom relief which is still low, norm around 12-14. ...Read more

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Is a folic acid blood test also called a folate serum blood test? If they are different tests, should I take both of them together with the Vitamin 12 test?

One and the same: Serum folic acid test is the better name. Why are you doing these tests? It would be better to let your doctor figure out if you need any tests. Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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Serum folate (folic acid) 5.0 ng/ml hct 23% vitamin B12 78 pg/ml MCV 116 fl 1, what does this mean?

Serum folate (folic acid) 5.0 ng/ml hct 23% vitamin B12 78 pg/ml MCV 116 fl 1, what does this mean?

Low B12: And your severe anemia and very large red blood cells (high MCV) are probably the result. If you are a vegetarian, please reconsider or get with someone who can guide you about the supplements you need. If not, and you feel healthy otherwise, it's likely you have a problem absorbing vitamin B12, and will need injections frequently to fix the anemia and avoid permanent brain damage. It's serious. ...Read more

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Hb was 4 in may12 now 7.5.Wbc111000.Tibc460.Serum folate (folic acid) >40.Problem- pain in legs and breating problem. Have any risk of blood cancer. What's your sug?

Hb was 4 in may12 now 7.5.Wbc111000.Tibc460.Serum folate (folic acid) >40.Problem- pain in legs and breating problem. Have any risk of blood cancer. What's your sug?

Communicate: If you have been severely anemic since last may and you do not know the cause, then there is a grave communications problem between you and your physician. This is probably not leukemia (blood cancer) -- if chronic you'd have abnormal cells in the blood, you've lived to long for acute leukemia. Demand a full account from your physician or a referral. Good luck and stay pro-active. ...Read more

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What would cause elevated B12 and folate (folic acid) levels?

What would cause elevated B12 and folate (folic acid) levels?

Stop worrying: We see these from time to time. They are no cause for concern. Reference ranges are set for the vast majority of people. Just be happy. Elevated B12 has some arcane significance in hematology but it does not apply to healthy people. Just be glad. ...Read more

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Are elevated B12 and folate (folic acid) levels bad? Cause of this? How to bring them down to normal levels?

Are elevated B12 and folate (folic acid) levels bad? Cause of this? How to bring them down to normal levels?

Needs evaluation: High B12 & folate (folic acid) is not dangerous per se (these vits. Have no known toxicity)& may not be serious, but high B12 may paradoxically be a sign of B12 deficiency & may also be caused by acute or chronic liver disease or leukemia, so deserves further evaluation-see http://healthyeating. Sfgate. Com/high-vitamin-b12-serum-levels-6037.Html
high folate (folic acid) may be a sign of B12 deficiency or blind loop syndrome. ...Read more

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My recent lab tests came back with Iron level of 30, transferrin of 20%, low vitamin D, high B12 and high folate. Is this cause for concern?

My recent lab tests came back with Iron level of 30, transferrin of 20%, low vitamin D, high B12 and high folate. Is this cause for concern?

Lab values: Low iron exists. Low vitamin D exists. These are not major threats but should be remedied. Take iron daily as a supplement. And add Vit d as a supplement. A real good iron pill is vitron C A good dose of Vit D is 1000 units per day ...Read more

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What would cause a slightly elevated B12 and folate (folic acid) level on complete blood count?

What would cause a slightly elevated B12 and folate (folic acid) level on complete blood count?

Dietary supplents: The most likely cause of elevated B12 and folate (folic acid) is dietary or parenteral supplements. Other sources of B12 and folate (folic acid) are the diet itself. Consult your doctor for more information. ...Read more

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Folic acid -24.6, serum B12 - 600, high folic acid may mask B12 def, what does that mean? Is serum B12 falsly high? What other tests for B12 def?

See below: Folic acid does not affect blood test results for B12, i.e., it will not cause falsely high B12 results. High folic acid may mask hematologic effects of B12 but not all functions of B12. ...Read more

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I am 7 weeks pregnant. Haemoglobin level 152g/L. Is it high for pregnancy? Platelets and MCV all normal. Serum folate 25.2 on folic acid, also high.

Probably normal: Your hemoglobin of 15.2 is fine for being 7 weeks pregnant. The numbers will decrease moreso in the 2nd and third trimesters. You should be on a multivit (prenatal) which has folic acid in it. Folic acid is very important in pregnancy.

Hope all is well otherwise. Good luck with your pregnancy! ...Read more

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12 weeks pregnant. Have high folate (folic acid) serum levels blood test-is this ok or dangerous? Do I stop vitamins? (takin pregnacare max with calc vit d &omega

12 weeks pregnant. Have high folate (folic acid) serum levels blood test-is this ok or dangerous? Do I stop vitamins? (takin pregnacare max with calc vit d &omega

TOTALLY SAFE: There is absolutely no known toxicity from folic acid. It is far better to have high levels than low. This just means you have more in your blood than most people but, again, this is not harmful in any way and will protect your baby from birth defects. ...Read more

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What happens if you have an abnormally high B12 level and high folate (folic acid) level?

High B12 Folate (folic acid): I understand your concern.

Researchers in Denmark have found that higher than normal levels of B12 may indicate a person is at risk of developing Lung, Colon and Liver cancer.

National Institute Health Research stated-High folate (folic acid) does not appear to increase the risk of anemia among healthy people with low B12 levels

See your physician for evaluation tests and treatment ...Read more

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Are low folate (folic acid) levels alone dangerous? They have been low for a year. Can it cause any damage to health?

Low folate (folic acid) bad: There's no reason to walk around with low folate (folic acid) levels. It's cheap and safe to supplement it. So don't sit around wondering if it hurt you in the past. Just take a supplement.
low folate (folic acid) in pregnant moms can cause birth defects.
Folate is involved in many crucial parts of our physiology. Low folate (folic acid) can be very bad for the body. ...Read more

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High folate and normal b12. Not taking anything but a multivitamin. What could cause this?

How high?: What do you mean by high folate? What you perceive to be high may well be normal. There is no toxicity with folate.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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Hi. I have folate deficiancy at 2. but my feritin levels are very high. I have been given folic acid to take everyday. Are the two linked?

Complete workup: You need to find out why you're folate (folic acid) deficient. This may simply involve modifying your diet to include more folate (folic acid)-rich foods. However, a very high serum ferritin warns of hemochromatosis. This is deadly if neglected but easily managed. They are not connected. Insist on a full explanation from your physician. ...Read more

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Had bloods done I've got high folate (folic acid) levels of 20:1 what does this mean I'm male b12 & hemoglobin are OK?

Normal: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Serum folate (folic acid) level of 20.1 is perfectly normal and is not a cause for any concern. ...Read more

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Are elevated B12 and folate (folic acid) levels a problem? My most recent blood work showed these both to be high...Any danger?

How high?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it would have helped to have the actual values of the results. In general high values for folate and B12 are not a problem. ...Read more

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I live in canada and recently had blood work done my RBC folate (folic acid) level was 2423 is this too high? What could it mean?

Likely no problem.: Folate (folic acid) in the rbcs is a test done to see if a person is folate (folic acid) deficient. For pregnant women, this could mean neural tube defects in the newborn if it is low, and megaloblastic anemia and malnutrition in adults. Your levels are well above the adult range of 150-450 ng/ml/cells (340-1020 nmol/l/cells), and you should have nothing to worry about. It is water soluable and excesss is urinated out. ...Read more

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My mom is 66 and has elevated homocysteine levels. B12 and folate (folic acid) are normal. On BP meds but systolic still high. Any thoughts or suggestions?

MTHFR: There are several causes for high homocysteine levels but the most common is the mthfr gene mutation. The mutation affects the metabolism of folic acid, which utilizes b12. Often, blood levels look normal but the body is actually not able to process the vitamins so the homocysteine remains elevated. Also, the B12 and folate might look "normal" but might not be optimal. More tests are needed. ...Read more

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When I have complete blood count done, B12 and folate (folic acid) are a tad high, then when a separate blood test is done for B12 and folate (folic acid), both are ok. Causes?

Doesn't make sense.: If the same test done for the levels, and shows different results, there may also be a lab error. I would repeat one again only for b 12 and folate (folic acid) and compare. ...Read more

Serum (Definition)

Serum is the component of blood that does not contain cells or clotting factors. It does contain electrolytes an ...Read more


Dr. Kristi Woods
649 Doctors shared insights

Folate (Definition)

Folate is a vitamin which is a kind of nutritional agent ...Read more