Doctor insights on:
High Mean Platelet Value
Large platelets: The mpv is a measure of how large the platelet is. Large platelets are presumptively young platelets. If the platelets are being used up or destroyed rapidly (dic or itp) then younger platelets are released into the blood and this is reflected in an increase in the mpv. Also some hereditary platelet disorders cause high mpv. ...Read more
Could be reactive: Many secondary cause including infection or underlying inflammatory conditions. Also bleeding, iron deficiency or people whose spleens have been removed. Sometimes, more associated with older populations conditions associated with primary bone marrow disorders called myleoproliferative disease can be associated with increase platelets. ...Read moreSee 1 more doctor answer
Thrombocytosis: High platelet count is indicative of either a primary bone marrow myeloproliferative disorder or a secondary cause like iron deficiency, stress. Primary disorders include et essential thrombocytosis are driven by jak2 mutation or CML driven by bcrabl mutation. High platelets cause risk of vascular thrombosis, tia, cva, mi. Underlying cause have to be diagnosed and treated to normalize counts. ...Read moreSee 1 more doctor answer
It depends: There is a wide range over which platelet counts can go before raising any concerns. Normally they range between 150, 000 to 400,000. if your count is over 450,000, get it rechecked . If the count rises above 500,000, you should get yourself checked by a hematologist(blood cancer specialiist ...Read more
Anemia: If someone have low hemoglobin called anemia, and as a result high platelet count called thrombocytosis, usual cause is iron deficiency. Iron deficiency anemia can lead to a stress or reactive thrombocytosis which will get better with iron replacement. Get your iron studies and ferritin checked. Thanks. ...Read more
Thanks for asking!: There are 2 major processes associated with thrombocytosis (high platelet count), namely (1) essential or primary; (2) reactive or secondary. Primary causes: essential thrombocytosis and other myeloproliferative disorders. Secondary causes include inflammation, surgery, hyposplenism (decreased platelet breakdown due to reduced function of the spleen), splenectomy, iron deficiency anemia, ...Etc. ...Read more
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