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Doctor insights on: High Grade Spindle Cell Sarcoma

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Help please! Is chemotherapy effective on high grade spindle cell sarcoma?

Help please! Is chemotherapy effective on high grade spindle cell sarcoma?

Yes it often is: Spindle cell cancers are often called sarcomas. They can arise either in the soft tissues or in the bones. Ask your doctor what is the name of your cancer? If it is a sarcoma, chemotherapy is useful in about half of the cases, often it is used in conjunction with surgery and radiotherapy. ...Read more

Dr. Tiffanie Noonan
2 Doctors shared insights

Sarcoma (Definition)

By definition, it is malignant (i.e., being locally invasive and at least theoreticlally capable of metastasizing), and arises from / mimics muscle or connective tissue elements that are not marrow or immune / white cells. The sarcomas are a tremendously varied and troublesome family of tumors, though thankfully less common than carcinomas and the leukemia / ...Read more


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I wanted to know is chemotherapy effective on high grade spindle cell sarcoma?

I wanted to know is chemotherapy effective on high grade spindle cell sarcoma?

Some help: High grade spindle cell sarcomas are aggressive and every effort to remove the primary, control the surgical site if larger than 10 cm with RT should be made. If metastatic foci are noted surgical resection can also benefit as seen with lung mets. Primary treatment with drugs like Ifosfamide and platinum may help but primary removal is most important ...Read more

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How fast does a spindle cell sarcoma grow?

How fast does a spindle cell sarcoma grow?

Lots of variety.: The term "spindle cell" sarcoma is a generic descriptive term that doesn't really give enough information. It would be like asking, "i saw a convertible, how fast can it go? " additional testing often reveals exactly what kind of sarcoma, and then once you know that, you can more accurately discuss the prognosis and the treatment. ...Read more

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What is prognosis for high grade abdominal sarcoma?

Depends: This will depend in the size of the tumor, was it resectable? Even if it was radiation is needed for high grade tumors. Even with the best case features these are aggressive and can recur or spread. So prognosis will depend on every factor I asked about including whether there has already been any spread of the sarcoma. ...Read more

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My 29 year old was daughter was diagnosis with high grade undifferentiated sarcoma primary site lung 13.9 CM mass removed in nov. What is her prognosis?

My 29 year old was daughter was diagnosis with high grade undifferentiated sarcoma primary site lung 13.9 CM mass removed in nov. What is her prognosis?

Variable: It depends on her stage of disease that I assume was early and her sarcoma had not metastasized and hence she had surgery.

She will need oncological follow up and chemotherapy may be indicated.

Please see an oncologist and discuss pathology reports with them. ...Read more

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Does the presence of spindle cells in a pap smear always indicate cancer or can they be present with moderate or severe dyskariosis? Ie cin3?

Does the presence of spindle cells in a pap smear always indicate cancer or can they be present with moderate or severe dyskariosis? Ie cin3?

Not always cancer: Spindle cells (sc) have bilateral tapering poles (like a football); their presence on pap smear indicates issues ranging from benign reactive or reparative changes, artifactual/normal squamous cell shape, to rare malignancies (carcinosarcoma, metastatic desmoplastic melanoma). Sc morphology is seen in connective tissue. Pap grade (high or low intraepithelial lesions, cin 1-3) is more tellig. N. ...Read more

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What does soft cell sarcoma feel like?

What does soft cell sarcoma feel like?

Often no symptoms: You may have no symptoms other than a soft tissue mass. ...Read more

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Can you tell me some odd cells that were on the tumorthey called it sarcoma. What is going to happen next?

Need more info: It depends on many factors. First, is it a sarcoma of bone or soft tissue. Bone sarcomas usually get chemo, while it is variable for soft tissue sarcomas. It also depends if the tumor had spread. In most cases sarcoma is treated with surgery. Talk to your doctor to get more answers. ...Read more

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What's the success rate for stem cell transplants in advanced stages of ewings sarcoma?

Clinical trials...: The largest published study to date (one institution) showed no increase in survival over conventional chemotherapy. However, this question is currently being evaluated in a collaborative clinical trial between europe and the us. See:
http://www.Cancer.Gov/clinicaltrials/search/view? Version=healthprofessional&cdrid=68608. ...Read more

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3 irregular lobular mass with slight subcutaneous edema above massconcern for soft tissue sarcoma. Possibly synovial cell. What exactly does this mean?

3 irregular lobular mass with slight subcutaneous edema above massconcern for soft tissue sarcoma. Possibly synovial cell. What exactly does this mean?

Soft tissue sarcoma: The imaging findings are concerning for a soft tissue sarcoma or other aggressive process. You should be evaluated by an orthopedic oncologist or at a sarcoma center. ...Read more

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My dad died of sarcoma of the kidney do I have a high risk of it? And is it common?

My dad died of sarcoma of the kidney do I have a high risk of it? And is it common?

It is rare: Sarcomas are rare cancers. They typically do not run in the families. Yet the kidney tumors do run in families, sometimes. You need to verify if this was kidney cancer with sarcoma like change which is called Sarcomatoid Renal cell carcinoma. ...Read more

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How many people have spindle cell neoplasm?

How many people have spindle cell neoplasm?

It is not rare: Spindle neoplasms are often labeled sarcomas which are an uncommon class of cancers, yet they make up about 10, 000 to 12, 000 cases in the us per year. ...Read more

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My co-worker was recently diagnosed with spindle cell neo plasma in her vagina. Will she die from this?

My co-worker was recently diagnosed with spindle cell neo plasma in her vagina. Will she die from this?

Not appropriate: You really should not be asking specific questions about another person's medical problems without his or her permission. ...Read more

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Following pap smear I need to have a colposcopic examination with biopsy and 'atypical spindle cell tumour needs to be excluded'. What is this?

Following pap smear I need to have a colposcopic examination with biopsy and 'atypical spindle cell tumour needs to be excluded'. What is this?

ASCUS: The preferred approach for evaluation of women ages 25 or older with ASC-US cytology is testing for high-risk types of HPV with triage of women who test positive to colposcopy. Use of HPV testing to triage further evaluation of ASC-US is the most effective strategy for detecting high-grade premalignant disease or cervical cancer. ...Read more

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Why is there a need for immunohistochemistry: smooth muscle actin after I got the diagnosis: cellular spindle cell lesion favor nodular fascitis?

Why is there a need for immunohistochemistry: smooth muscle actin after I got the diagnosis: cellular spindle cell lesion favor nodular fascitis?

To help diagnosis: Pathologists often use immunohistochemistry to help in arriving at a diagnosis. For softn tissue tumors immunohistochemistry can help better characterize the type of tumor...For example if is smooth muscle derived or a neural tumor etc. In terms of nodular fasciitis, it can morphologically appear similar to some smooth muscle tumors and some other fibroblastic tumors so ihc may be used. ...Read more

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May I know the simple explanation for this diagnosis: (post auricular area), excision biopsy: cellular spindle cell lesion favor nodular fascitis?

May I know the simple explanation for this diagnosis: (post auricular area), excision biopsy: cellular spindle cell lesion favor nodular fascitis?

Get 2nd opinion: A pathologist who trained at one of my institutions self-diagnosed a sarcoma and had his arm amputated, only to discover later it was nodular fasciitis, which is very benign. I was trained by some of the great pathologists and even they said they'd never call nodular fasciitis without a second pathologist agreeing. I'd suggest showing 3-4 of us pathologists. Good luck. ...Read more

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Can you tell me what the significance is of spindle cells being found in a cervical smear test? I have had colposcopy and biopsy, awaiting results.

Can you tell me what the significance is of spindle cells being found in a cervical smear test? I have had colposcopy and biopsy, awaiting results.

Variable.: If the final interpretation is negative for malignant cells, you are ok!
as highlighted in one of the replies 'spindle' cells just reflect the shape of cells, which may be benign or malignant (and may be epithelial or stromal from deeper tissue). If malignant, usually it is keratinizing squamous cell carcinoma with 'fiber' cells. Other malignant causes are very rare (e.g. Sarcomas, melanoma, mmt). ...Read more

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Pap Smear result: A single group of spindle cells admixed with neutrophils is seen representing atypical spindle cell proliferation. Is it cancer?

Pap Smear result: A single group of spindle cells admixed with neutrophils is seen representing atypical spindle cell proliferation. Is it cancer?

No, BUT: Several points. First, you need more than atypical to say it is cancer. They have to look quite abnormal and/or be growing abnormally. HOWEVER, there are reports of groups of atypical spindle cells popping up everywhere due to cancer (lymphoma). That would be cancer. Or growing really fast (cancer).
At a minimum. Watching it Really closely. ...Read more

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Post neck dissection and head lesion removal. Mets from head to neck. Path results: malignant epithelioid and spindle cell neoplasm-english please.?

Post neck dissection and head lesion removal. Mets from head to neck. Path results: malignant epithelioid and spindle cell neoplasm-english please.?

Provisional: This is a preliminary report while the pathologist does more work to get the exact nature of the tumor settled down. I suspect this will turn out to be a carcinosarcoma. This is a difficult case and your physician will probably want several pathologists' signatures on the final report. ...Read more

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What is the prognosis of Spindle cell melanoma T4 lesion on the scalp? Other than the surgery, what other treatments have been successful?

What is the prognosis of Spindle cell melanoma T4 lesion on the scalp? Other than the surgery, what other treatments have been successful?

Micro: surgery is the only "curative" treatment! This may be accompanied by Radiation of draining lymph nodes.
IMMUNOTHERAPY is "ijn the works" but thus far does not seem to "add" life years!
Hope this is helpful/Good Luck!

Dr Z ...Read more

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Atypical spindle cells found In lymph gland on left parotid gland. What could this be please? No sign of metastasis also. Had melanoma and now clear

Atypical spindle cells found In lymph gland on left parotid gland. What could this be please? No sign of metastasis also. Had melanoma and now clear

Pathologist: It would be appropriate to consult with the pathologist who issued the report. It would be helpful for you and your doctor to talk to the pathologist together. ...Read more

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Do a lot of people get sarcoma?

Do a lot of people get sarcoma?

Relatively rare: Sarcomas are a diverse and relatively rare group of malignant tumors that develop in soft tissue and bone. Soft tissue sarcomas form in fat, muscles, nerves, joints, blood vessels, and deep skin tissues. It is estimated that in 2011, approximately 10, 980 and 2, 810 americans will be diagnosed with soft tissue and bone sarcomas, respectively. ...Read more

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What are the most common symptoms of sarcoma?

Mass, sometimes pain: The most common finding is an enlarging mass. It is often non-tender but can be painful. But often there are really no symptoms other that the mass itself, . ...Read more

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Do lots of people get sarcoma, or is it unusual?

Not too common: There are about 12, 000 new cases of soft tissue sarcoma every year in the US - so yes it is not a common cancer. ...Read more

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Is there one best test to diagnose ewing's sarcoma?

Is there one best test to diagnose ewing's sarcoma?

Not one: Ewing sarcoma is relatively rare tumor mostly seen in young adults 10 to 20 yrs age involving the long & flat bones, presents with pain swelling, 30% of the time already spreads. Simple x ray will show bone lining (perosteal) reaction, MRI, ct, bone scan, pet scan, are all diagnostic tools, confirmation is by biopsy ...Read more

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What exactly is soft tissue sarcoma?

Soft tissue cancer: Sarcomas are cancers that affect the cells that are part of the support structure of our bodies. The more common type of cancer, adenocarcinomas, start in glands of the body, like breast, colon, lung, etc. But sarcomas start in bone, fat, muscles, ligaments and some parts of the skin, . ...Read more

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What are the signs of soft tissue sarcoma?

Painless mass: Most soft tissue sarcomas, with few exceptions like synovial sarcoma, are painless. Patients and even some doctors are falsely reassured by the absence of pain. Sarcomas may grow quickly or very slowly, but any painless mass has to be evaluated appropriately. While a painless mass can turn out to be a benign lipoma, a sarcoma has to be ruled out. An MRI can readily diagnose a lipoma. ...Read more