Top 20 Doctor insights on: High c4 complement levels

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Dr. Barbara Lavi
22 Doctors shared insights

Complement Levels (Definition)

Total complement activity (CH50, CH100) looks at the overall activity of the complement system. Typically, other tests that are more specific for the suspected disease are performed first. C3 and C4 are the most commonly measured complement components. A complement test may be used to monitor patients with an autoimmune disorder and to see if treatment for their condition is working. For example, patients with active lupus erythematosus may have lower-than-normal levels of the complement ...Read more


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Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical?

Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical?

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

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Should I see a rheumatologist if I have elevated complement levels?

Should I see a rheumatologist if I have elevated complement levels?

Don t think so: Complement is an acute phase reactantant, having high complement levels only means there is a reaction, probably inflammatory. If the diagnosis is ulcerative colitis, but you don t have arthritis youndont need to see the rheumatologist for high complement leves. ...Read more

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I've never head of complement levels, what do they mean when they are low?

I've never head of complement levels, what do they mean when they are low?

Complement: Complement are proteins in the blood that are part of the immune system. Individuals with very low or absent complement are prone to infections such as recurrent neisseria meningitis. If the blood test isn't put on ice right after it is drawn, then a low level could result that is incorrect. ...Read more

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What would having low complement levels indicate?

What would having low complement levels indicate?

Low complement: Low levels of complement are seen in persons with complement deficiency who are prone to recurrent infections as well as in certain autoimmune conditions, inherited angioedema conditions, and hives associated with vasculitis (inflammed blood vessels). These can all be serious. Collection of blood to measure complement is tricky and needs to be done right or low level could occur. ...Read more

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What do low complement levels indicate is going on?

What do low complement levels indicate is going on?

Some things: To consider:
1) autoimmunity (particularly sle)
2) immunodeficiency
3) blood dyscrasia or cancer. ...Read more

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I have vesico-ureteric reflux and acute hypertension, why would complement levels be an investigation?

See Below: Most likely they are looking to see if your body is attacking your kidneys by activating complement proteins in the kidney tissue. If there is complement deposition there then the explanation for your hypertension may be injury to your kidneys from this. ...Read more

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Can low complement levels cause lichen planus (armpit) and tinea versicolor?

Can low complement levels cause lichen planus (armpit) and tinea versicolor?

Yes and no: Tinea versicolor is a fungal infection. It may present due to a decrease in the immune system (low complement). Lichen planus is an autoimmune disorder of unknown origin. Various autoimmune illnesses are associated with increased incidence in lichen planus. Secondary raynaud's disease also has been linked with some autoinmune disorders such as lupus, rheumatoid arthritis and sjogren's syndrome. ...Read more

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Can you have lupus with completely normal bloodwork? ANA, ENA neg, Complement levels normal, CBC normal. ESR of 2 and normal CRP

Can you have lupus with completely normal bloodwork? ANA, ENA neg, Complement levels normal, CBC normal. ESR of 2 and normal CRP

ANA negative lupus: There is an entity called ANA negative lupus. Please visit this site for diagnostic criteria for SLE. From what you have described, it is unlikely that you have lupus.

http://www. Lupusresearchinstitute. Org/lupus-facts/lupus-diagnosis ...Read more

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What does it mean when you have high levels of complement c4 and sedimentation rate westergren?

What does it mean when you have high levels of complement c4 and sedimentation rate westergren?

Complement C4/ESR: Complement C4 and the erythrocyte sedimentation rate are usually high in conditions which cause acute or chronic inflammation. These are often measured in autoimmune diseases and rheumatoid arthritis, but they can be elevated in many other conditions, including cancer and heart attacks. The results need to be interpreted by your physician. Good luck. ...Read more

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I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal (57 u/ml)- (all are serum tests)-what are the possible causes?

Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. ...Read more

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What could high immunoglobulin IG m and complement C4 mean?

What could high immunoglobulin IG m and complement C4 mean?

May be significant: Immunogloblin m (igm) is one of the 5 classes of proteins that have antibodies. C4 is part of the complement cascade, a series of proteins that are important in immunity and inflammation. Elevation of both may occur in various diseases. The significance of the specific values for you depends on what your clinical problem is. Therefore, I can not be more specific as to what it means for you. ...Read more

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My C4 complement level is low and C3 complement is at the low end of the range (90, ref range 90-180). What could this mean?

May be significant: Low Complement levels may be nonspecific markers for autoimmune disorders. Other symptoms and clinical findings are needed to be able to adequately answer your question. ...Read more

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What means very high CH50 complement? Mine is 277 CAE, C3 and C4 normal. Ref ranges for lab are only greater than 60, but I read high could be pathologis

How do you feel?: The complement system is a chaotic system -- like the butterfly effect. Most-impacted by this is CH40. The CH50 test is subject to so many variables and artifacts that as long as you feel reasonably well and don't have some bizarre, mysterious illness, I wouldn't give an elevated value a second thought. ...Read more

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2yr old had blood work done in Dec & in Feb results are saying she had a high C3, C4 Complement & high C-Reactive protein & ES rate what's wrong?

2yr old had blood work done in Dec & in Feb results are saying she had a high C3, C4 Complement & high C-Reactive protein & ES rate what's wrong?

Abnormal labs: These lab results could mean different things depending on her symptoms I would suggest a follow up visit with the ordering doctor to discuss these results. ...Read more

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High positive ANA for years and now tested elevated complement C4 and C3 but all other autoimmune antibodies are still negative. What could that be?

Inflammation: Complement is a phase reactant which means it will go up with any type of inflammation. It is not specific for any one problem. A low complement is of more concern. These lab texts could mean you will eventually develop an autoimmune disease or other disease process associated with ANA. They slso may never amount to anything. ...Read more

Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more