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Doctor insights on: High Anion Gap Child Low Creatinine

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I have a low anion gap, low estGFR, a high Microalbumin/Creatinine ratio, HA1C and a high ALT. Any concerns/thoughts?

I have a low anion gap, low estGFR, a high Microalbumin/Creatinine ratio, HA1C and a high ALT. Any concerns/thoughts?

Diabetic kidney: These are signs of emerging diabetic kidney disease and likely fatty liver from diabetes. Is concerning. High Microalbumin/creatinine ratio indicates albumin leak into urine from overt diabetic kidney change. The low eGFR indicates kidney impairment. The low anion gap reflects low albumin in blood and would indicate high spillage of albumin into urine. High A1c indicates poor glucose control. ...Read more

Dr. Madhu Kandarpa
2,220 Doctors shared insights

Creatinine (Definition)

Creatinine is a byproduct of creatine phosphate, which is present in muscles. Creatinine levels increase if the ...Read more


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Low co2, elevated anion gap, elevated pH of 7.5, low creatinine of. 2 in toddler with slow growth born prematurely at 31 weeks ga & 2 vessel cord?

Consider...: ...The possibility of a genetic or metabolic disease which will create excess anions (the anion "gap"). Examples would include Lactic Acid built up in cells that undergo anaerobic metabolism, or acids that build up such as ketoacids in the face of diabetes. A 2 vessel cord suggests a kidney or genetic anomaly and should have a genetics and nephrology evaluation. ...Read more

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I recently had some blood test done. Creatinine came back as 1.6, BUN is 19, glucose on the high side.....all other measurements are witin the range except for anion gap. Anion gap is 13, slightly above range. What does this all mean?

I recently had some blood test done. Creatinine came back as 1.6, BUN is 19, glucose on the high side.....all other measurements are witin the range except for anion gap. Anion gap is 13, slightly above range. What does this all mean?

Hard to say: Without knowing your past medical history and past testing. But from what you mention your testing suggest some element of kidney dysfunction. It's not clear if it's chronic or acute. But you should reach out to your doctor if you have questions too. He/she will know you vest to be able to give you the most accurate description of what's going on. ...Read more

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What amylase level is too high for female? What can be problems if also high BUN/Creatinine ratio, high anion gap, and high direct bilirubin?

What amylase level is too high for female? What can be problems if also high BUN/Creatinine ratio, high anion gap, and high direct bilirubin?

Why do you ask?: Amylase kay be very high without being a problem because of a harmless variant called macroamylasemia. The ratio is useful only to explain other abnormals is obvious disease. Same is basically true if the gap. If you feel well, slightly high direct bilirubin may be meds or a minir metabolic glitch. Your physician is your best guide. ...Read more

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28 yr female, creatinine. 71 mg/dl, anion gap 14, others good except glucose only 51. Are these numbers ok or could indicate early issues?

28 yr female, creatinine. 71 mg/dl, anion gap 14, others good except glucose only 51. Are these numbers ok or could indicate early issues?

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your lab values appear normal. Glucose is lower than normal but if you do not have symptoms, it would be better to leave it alone. ...Read more

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78.8 mcv, 26 mch, 15.2 rdw, 0.6 creatinine, 5 anion gap. Could you please interpret these labs for me? Thank you!

Looks like low blood: You have a low MCV and mchc. Your RDW is high and your anion gap and creatinine are normal. It looks like with your high RDW and other low blood results that you've got some anemic process going on. The high RDW could mean that there is a destructive process to your red cells as this shows a great difference in the size of your red cells. It would help to see your dr. And get a blood smear. ...Read more

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Are these labs cause for concern? Calcium 8.7 L Creatinine 0.61 L Anion Gap 13.9 H Epithelial Cells- Many WBC-10-20

Are these labs cause for concern? Calcium 8.7 L Creatinine 0.61 L Anion Gap 13.9 H Epithelial Cells- Many WBC-10-20

May be WBC: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, I trust the WBC 10-20 was in urine. If so, it should be repeated with proper urine collection of mid-stream specimen, after cleaning the external genitalia. Your doctor can advise on proper collection technique. Others are okay. ...Read more

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What causes a high anion gap and low bicarbonate (sodium bicarbonate)?

What causes a high anion gap and low bicarbonate (sodium bicarbonate)?

Metabolic Acidosis: In medicine, metabolic acidosis is a condition that occurs when the body produces too much acid or when the kidneys are not removing enough acid from the body. If unchecked, metabolic acidosis leads to acidemia, i.e., blood ph is low (less than 7.35) due to increased production of hydrogen by the body or the inability of the body to form bicarbonate (sodium bicarbonate) (hco3-) in the kidney. ...Read more

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What are implications high anion gap, ige, anc, rdw-cv, abs mono, CRP, compliment 3&4, and low mcv, mch?

What are implications high anion gap, ige, anc, rdw-cv, abs mono, CRP, compliment 3&4, and low mcv, mch?

Some inflammation: The tests do not make a diagnosis. High anion gap can be due to several processes;. Increased neutrophils, crp, complement C3 ; C4 are all suggestive of some inflammatory process (not necessarily infection). Mono antibodies are present in many people: increased ige - allergy and smoking; low MCV and MCH - low iron and/or a chronic inflammation. Check with your physician asap. ...Read more

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Is a low anion gap and high chloride level something to be concerned about?

Is a low anion gap and high chloride level something to be concerned about?

Anion Gap: The anion gap is calculated from the following formula: Sodium minus choride plus bicarbonate. Normal is 8 to 16 mEq/L There is more importance to an elevated anion gap which can be associated with extra acids in your body like alcohol aspirin, or diabetic ketoacidosis. ...Read more

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What can happen when the blood test show low bicarbonate (sodium bicarbonate) level and high anion gap?

Seek the cause: This can be due to any thing from exercising hard and not being fully recovered, to being in shock, to having some unmeasured anion (aspirin, drank antifreeze, diabetic ketoacidosis), to a variety of other things. Your physician is hopefully competent and can find the cause -- it's one of the most basic workups in medicine. Best wishes. ...Read more

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Blood test: low alk phos & vit d, c-react protein 7.35, na 146, creat up from 60 - 80 & crcl down frm 101 to 76 in 2 mo, anion gap high, GFR 60 why?

Blood test: low alk phos & vit d, c-react protein 7.35, na 146, creat up from 60 - 80 & crcl down frm 101 to 76 in 2 mo, anion gap high, GFR 60 why?

More than one issue: The lab values you provided suggest more than one issue, one being kidney disease and the other being inflammation and may be more. Lab tests need to interpreted in the clinical context and you should discuss these results with your doctor at your earliest to prevent further damage. ...Read more

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Blood work results, chloride was low at 98 mmol, anion gap was high at 17.4, glucose was high at 108 mg/dl, A1c was 6.2, albumin/globulin ratio 2.0?

Blood work results, chloride was low at 98 mmol, anion gap was high at 17.4, glucose was high at 108 mg/dl, A1c was 6.2, albumin/globulin ratio 2.0?

Prediabetes: Hi. That A1c is above normal, & if that glucose is FASTING, it is too (it's not abnormal if it's not fasting). They demonstrate "prediabetes", the abnormal state between normal & diabetes. What was your bicarb/total CO2? Unless it was low, anion gap (a calculated value) doesn't mean anything; it's useful in states of ketoacidosis, lactic acidosis, etc). A:G ratio is fine too. Eat healthy, exercise ...Read more

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Gallstone, 31% EF, low total bilirubin, high anion gap, hx of elevated liver enzymes. Liver enzymes leveled out after taking hormones. Causes? Advice?

Gallstone, 31% EF, low total bilirubin, high anion gap, hx of elevated liver enzymes. Liver enzymes leveled out after taking hormones. Causes? Advice?

HF: You have complex issues. Why do you have HF and also the cause of liver disease? The AGMA is concerning and has to be worked up. Some of these conditions can be related. What hormones did you take? I have more questions than answers, more so because you have 2 organ dysfunction and a acid base disorder and they can be related. ...Read more

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Low red blood cells, very low anion gap, and high blood protein. Should I worry about multiple myeloma? Back/hip pain recent.

Low red blood cells, very low anion gap, and high blood protein. Should I worry about multiple myeloma? Back/hip pain recent.

Anything Is possible: There are numerous possible causes. Have your doctor order a serum protein electrophoresis blood test. If there is no monoclonal spike then myeloma is ruled out. ...Read more

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7mm periampullary lesion, 3 liver lesions, total beta hCG is high, anion gap-10, monocytes-1.1, chloride high, erc low, cbd & pancreatic duct dilation?

7mm periampullary lesion, 3 liver lesions, total beta hCG is high, anion gap-10, monocytes-1.1, chloride high, erc low, cbd & pancreatic duct dilation?

Your question?: I appreciate your sharing this, but no one here will be able to make the call. Unless your HCG is extremely high, it means nothing. The other labs are not helpful. Your periampullary lesion has hopefully been biopsied, as will your liver lesions if the radiologist cannot certify them as benign. Hoping celiac sprue has been ruled in or out, along with whipple's and common lactose intolerance. ...Read more

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What does it mean when your anion gap is high?

Acidosis: It means there is too much acid in your blood at the expense of more negatively charged substances (anions) being consumed (bicarbonate (sodium bicarbonate) (sodium bicarbonate (sodium bicarbonate)) and chloride) than positively charged substances (unmeasured cations h+), which consume the bicarbonate (sodium bicarbonate). ...Read more

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What is high anion gap metabolic acidosis?

What is high anion gap metabolic acidosis?

Metabolic acidosis: A high anion gap acidosis, (h), is an acidosis with a low carbon dioxide (c) and a normal chloride. This low c indicates the presence of an organic acid, such as lactic acid. H is seen in sepsis and diabetic ketoacidosis, among other conditions. It is a serious condition that requires immediate medical therapy to resolve it, as it is often life-threatening. ...Read more

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What is a high anion gap reading. When should I be concerned.?

What is a high anion gap reading. When should I be concerned.?

16+: Each lab has its own range of normals. Ag was a concept designed to help doctors figure out the source of acidosis, just a tool not a measure of how sick you are. If you are significantly acidotic the ag is useful. If you are not acidotic it is just a number spit out by the lab. A low ag may be seen with multiple myeloma. ...Read more

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What does high mpv and high anion gap mean?

What does high mpv and high anion gap mean?

Nothing: Labs mean nothing in isolation. High MPV usually means nothing in any case unless the person is otherwise clearly sick. I raise my anion gap every time I exercise. Reference ranges are set so that several percent of healthy folks fall outside on either end. If your phyiscian isn't worried, stop worrying yourself. Best wishes. ...Read more

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What does it mean if your anion gap is low and your sodium is normal in the middle of the range? Should I be concerned?

What does it mean if your anion gap is low and your sodium is normal in the middle of the range? Should I be concerned?

No need for worry: The anion gap is calculated by subtracting serum concentrations of chloride and bicarbonate (sodium bicarbonate) ions from sodium. If it falls below 3 meq/l, it is defined as low. The most common cause is laboratory error. Another less common explanation includes a low serum Albumin concentration. ...Read more

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What does this mean "high anion gap metabolic acidosis"?

Anion gap: The anion gap is a calculation in which you subtract the sum of the negative ions in the blood (chloride, bicarbonate) from the sum of the positive ions (sodium, potassium). Often potassium is left out because it has only a very small effect. A normal gap is < 11. If the result of the subtraction is > 11 you have a high anion gap acidosis, which means some other acid is causing acidosis (ketoacids. ...Read more

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Should a person worry if anion gap is low at 3.9?

No: This means nothing. Reference ranges are arbitrarily set so that 5% or so of healthy folks fall outside. ...Read more

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Is normochloremic normokalemic RTA possible? Anion gap usually normal. Sodium usually on low end of normal.

Is normochloremic normokalemic RTA possible? Anion gap usually normal. Sodium usually on low end of normal.

Unlikely to be RTA: Further evaluation with comprehensive history, physical exam and repeated labs are needed to determine the true significance of abnormal blood work results. Recommend discussing your concerns with a PCP and/or kidney specialist. ...Read more