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Doctor insights on: Hereditary Nonpolyposis Colon Cancer

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What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

Both inherited: In fap presents as colonic polyps ( gardners syn will have other tumors ) , autosomal recessive due to mutations in gate keeper, tumor suppres gene. On the contrary hnpcc or lynch syndrome. Is autosomal dominant, due to dna mismatch in repair, associated with other cancers of stomach, endomet. Ca, ovary, brain, skin etc. ...Read more

Dr. Barry Rosen
4,344 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Is colon cancer genetic?

Is colon cancer genetic?

Sometimes: Some colon cancers are related to specific genetic mutations but the majority are not. ...Read more

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Is bowel cancer hereditary?

Is bowel cancer hereditary?

Somehow yes: There is some genetic predisposition in families with hx. Of colorectal cancer. Diet also plays a rol ( low fiber diet increases cancer). Familiar poliposis increases chances of colon cancer. Colon polyps may degenerate in cancer. Small intestine cancers are rare and difficult to find. In general there are families affected by cancers and families affected by atherosclerosis but both together too. ...Read more

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Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca. ...Read more

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Is rectal cancer hereditary?

Is rectal cancer hereditary?

Usually not : Most patients with rectal cancer have not inherited it. A small subset have genetic mutations that put them at risk. Probably around 5 % of rectal cancers are hereditary. ...Read more

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Colorectal cancer causes?

Colorectal cancer causes?

Heredity & diet: The cause is not known in most cases. In a small number the cause is clearly heredity, e.g., apc and hnpcc. In the garden variety colon cancer, a diet low in fiber and rich in fats may increase the risk of cancer. ...Read more

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Is pancreatic cancer genetic?

Is pancreatic cancer genetic?

A minority is.: Pancreatic adenocarcinoma, arising from ducts/epithelial tissue, is mainly "sporadic", but can run in families. Pancreatic cancer has also been related to brca mutation, fammm syndrome, and some other inherited conditions. The familial pancreatic cancer registry is at johns hopkins. A minority of neuroendocrine tumors of the pancreas are associated with multiple endocrine neoplasia (men) syndromes. ...Read more

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Is bowel cancer genetic?

Is bowel cancer genetic?

Sometimes: Some colon cancers are related to inheritable genetic mutations but the majority are not. ...Read more

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For what reason colon part is usually prone to cancer in hnpcc (hereditary hereditary nonpolyposis colorectal cancer)?

Genetic disorder: Hnpcc also called lynch syndrome results from at least four type of genetic defects involving genes needed for repair of damaged dna. See this site for more info. http://ghr.nlm.nih.gov/condition/lynch-syndrome. ...Read more

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Who should undergo genetic counseling for hereditary non-polyposis colorectal cancer (hnpcc)?

Who should undergo genetic counseling for hereditary non-polyposis colorectal cancer (hnpcc)?

Family history: There are a number of different inherited defects that cause hnpcc. A person with strong family history of colon cancer, occurring at a young age should seek counseling. ...Read more

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Is bladder cancer hereditary?

No: Tobacco and environmental exposures to dyes for urothelial cancer; schistosoma hematobium, a parasite in egypt and chronic csatheterization for squamous cancr, and adenocarcinoma related to remnants of the urachus, the foetal conduit of urinary exretion through umbilicus into placental circulation...In this last case one might say "inborn error" but not genetic or hereditary. ...Read more

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Is lung cancer hereditary?

Is lung cancer hereditary?

Unclear: Non or never smokers can develop lung cancer if they have a genetic mutation to such genes as egfr or eml4/alk fusion translocation. For more info: http://bit.Ly/ygfoko. ...Read more

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How is colon cancer inherited?

How is colon cancer inherited?

Genes: Most colon cancers are not inherited. However, there is a subset which is associated with inherited genetic abnormalities such as hereditary polyposis a this hereditary non polyposis gene (hnpp). There are also syndromes that make you susceptible to a variety of different cancers including colon cancer such as lynch syndrome. ...Read more

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Is ovarian cancer genetic?

Sometimes: Certain genotypes such as the brca mutations have a higher incidence of ovarian cancer. ...Read more

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Are breast cancer and colon cancer linked?

Are breast cancer and colon cancer linked?

Not directly usually: There is debate about how closely these 2 cancers are related. Both have hereditary natures and are more common generally in obese patients. Both often begin with more benign precursor lesions like dcis for breast cancer and benign polyps for colon cancer. Both are very common but there is little evidence that having either predisposes to having the other. ...Read more

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How is familial adenomatous polyposis inherited?

How is familial adenomatous polyposis inherited?

Autosomal dominant: Enter omim in your browser and go to the database of all inherited diseases. Autosomal dominant means that affected individuals have one normal and one abnormal gene copy, the abnormal one dominating to cause disease. An affected person has a 50% chance to pass on the abnormal gene and fap with each pregnancy. ...Read more

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How is familial adenomatous polyposis inherited?

How is familial adenomatous polyposis inherited?

Autosomal Dominant: Fap is inherited in an autosomal dominant fashion. This means that if one parent has the gene, and the other parent doesn't, each child has a 50% chance of receiving the gene for fap. The disease causes hundreds of polyps to form in the colon (see the picture), leading to colon cancer. ...Read more

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Is colon cancer curable?

Is colon cancer curable?

Yes: Yes. Many people are cured with colon cancer. If found early surgery alone may be curable. If more advanced (eg, lymph node involvement or metastatic = spread to areas outside of colon), then chemotherapy may be needed. While less likely, even a few % of people with metastatic colon ca may be cured. ...Read more

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Is the pancreatic cancer hereditary?

Is  the pancreatic cancer hereditary?

It may be hereditary: There is some evidence that pancreatic cancer may occur more in some families. Johns hopkins was doing a study on families with pancreatic cancer where by relatives were having very close followup that included ct scanning and surgery if there was suspicion of a developing cancer. I do not know if the study is still ongoing. ...Read more

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What are the symptoms of hereditary colon cancer?

None: Colon cancer does not cause symptoms unless advanced. Definitely bleeding rectally is one that you should not ignore. ...Read more

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Question about hereditary colon cancer. Can it skip generations?

Question about hereditary colon cancer. Can it skip generations?

Yes: The genes that contribute to colon cancer are related to how cells grow or repair themselves. Skipping a generation may mean that the gene is not fully expressed or that other environmental factors did not quite tip the balance in favor of cancer. ...Read more

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Question about hereditary colon cancer: which kinds are inherited or run in families?

Question about hereditary colon cancer: which kinds are inherited or run in families?

Several.: The types of colorectal cancers you refer to include hnpcc (hereditary nonpolyposis colorectal cancer) and fap (familial adenomatous polyposis). However, each of these can also arise form a new mutation with no family history. Garden variety colorectal cancer also has some heritability, though far less than those noted above. ...Read more

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Is colon cancer Hereditary? Note my father and aunt has it. How can i identify iam 26 now

Family risk: You will want to get colonoscopy from time to time starting soon. Your family members may also be checked for genetic problems such as HPNCC and familial polyposis; if they are affected, you may be checked as well. Getting 'scoped frequently greatly diminishes your risk of dying of this illness. ...Read more

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If theres hereditary predisposition of colon cancer how often should a person do colonoscopy and wha are the risk factors? And What is polyposis test?

If theres hereditary predisposition of colon cancer how often should a person do colonoscopy and wha are the risk factors? And What is polyposis test?

Colon CA/screening: ACS screening for families that have a strong history. There are families that have predisposition to develop color and rectal CA. They say screening should start 10 yrs prior to the family members Dx. Say mom Dx at 40, screening would start at 30 in her family. Once you've had the first scope re can be made on the frequency, every 3 to 5 yrs depending on number of members Dx. ...Read more

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What is the treatment for hereditary colon cancer?

What is the treatment for hereditary colon cancer?

Depends: There are a number of inherited defects that may lead to colon cancer. In some cases, e.g. Apc, a prophylactic colectomy is advisable. In most cases the treatment is the same as for sporadic cancer. ...Read more

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Help please! is colon cancer hereditary?

Help please! is colon cancer hereditary?

Can be: Most colon cancers relate more to lifestyle than inheritance but some patients do have an inherited predisposition, be it in the setting of multiple polyps (like fap or myh) or not (lynch syndrome). Families with this have early onset colon cancer and other cancers as well. Talk to your doc about this to see if you need to visit a specialist in inherited malignancies. Remember to live healthy. ...Read more

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Can you explain hereditary colon cancer?

Can you explain  hereditary colon cancer?

Not in 400 character: Many genes are linked with an increased risk of colon cancer (and others), so those with a family history of colon, uterine and other cancers are at increased risk as they may inherit these genes from their parents. Genetic testing can pinpoint some of these genes and thus indicate whether you are at increased risk, thus allowing earlier detection/prevention/treatment so get checked if this appies. ...Read more

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What is the definition or description of: Hereditary colon cancer?

What is the definition or description of: Hereditary colon cancer?

5-10% of colon CA's: ...include: familial adenomatous polyposis (FAP) and Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). In addition, some rare conditions – including attenuated familial adenomatous polyposis (AFAP) and MUTYH-associated polyposis (MAP). Read: https://www.mskcc.org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counseling/inherited-risk-colorectal ...Read more

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If a person in their mid 30's were to get colon cancer would it almost always be due to a hereditary form of cancer compared to sporadic?

If a person in their mid 30's were to get colon cancer would it almost always be due to a hereditary form of cancer compared to sporadic?

Maybe: Some hereditary factors increase colon cancer risks such as some types of colitis (ulcerative colitis, crohn's disease), familial polyposis, hnpcc, lynch syndrome, etc. But younger people can get spontaneous colon cancers too. Get a referral to a gastroenterologist as indicated. Most colon cancer occurs after age 50, and reported 8-10 people per 100, 000 get colon cancer under age 50. ...Read more

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How is colon cancer inherited?

Genes: Most colon cancers are not inherited. However, there is a subset which is associated with inherited genetic abnormalities such as hereditary polyposis a this hereditary non polyposis gene (hnpp). There are also syndromes that make you susceptible to a variety of different cancers including colon cancer such as lynch syndrome. ...Read more

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I need your expertise, is colon cancer hereditary?

Some colon cancers: Are hereditary. Vast majority are not. The two common hereditary forms of colon cancer are familial adneomatous polys and lynch syndrome. Let me reiterate that hereditary colon cancers are a minority. See this site for more info. http://www.mskcc.org/cancer-care/hereditary-genetics/inherited-risk-colorectal. ...Read more

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Can children get colon cancer?

Can children get colon cancer?

Yes: Usually adult children. The youngest patient I have seen in my practice with a family history of colon cancer, was first diagnosed at age 18. ...Read more

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Where does colon cancer spread to?

Where does colon cancer spread to?

Colon ca mets: Most commonly to the liver. Then to the lungs. Rectal cancer may spread to lung before spreading to liver. ...Read more

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How fast does colon cancer spread?

How fast does colon cancer spread?

Unpredictable: Colon cancer spread to local lymph nodes and then on to other organs such as liver, lungs, bones. It can spread through the blood vessels or locally to other organs such as kidneys, prostate, etc. Rate of spread is unpredictable at present and likely depends on growth factors, cancer differentiation, and unknown factors. Of cancers that comeback after surgery, most (80%) do so within 3 years. ...Read more

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How can colon cancer affect the body?

How can colon cancer affect the body?

Blockage/Bleeding: Depending on their size and location, colon cancers may cause the above problems. The bleeding tends to be very slow, like a dripping faucet, and may not be evident by sight. Obstruction can cause a change in bowel habits (constipation, pencil-thin stools) and/or bloating. Like any cancer, there is the potential to spread to other organs, which may cause fatigue, loss of appetite, wt loss, etc. ...Read more

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What does colon cancer do to my body?

What does colon cancer do to my body?

Depends...: I like dr. Kaplan's answer but want to add that colon cancer may be silent until it's too late. Screening is very important therefore. ...Read more

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How does colon cancer affect the body?

How does colon cancer affect the body?

Depends: Early on there may be no effect. As the disease progresses undiagnosed, you may develop a change in bowels, blood in stool, abdominal pain, weight loss, loss of appetite, lethargy, loss of stamina, bowel obstruction, shortness of breath, anemia, early diagnosis in high risk patients or regular colonoscopies is the best way to avoid all of the above. ...Read more

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Dr. Linda Callaghan
13 doctors shared insights

Colon (Definition)

The colon is another term for the large intestine. This is the final portion of the digestive system, responsible for absorbing water and storing stool before evacuation. It is divided into sections described as cecum; ascending, transverse, descending and ...Read more


Dr. Jan Lei Iwata
12 doctors shared insights

Colonic (Definition)

This is a combining term referring to some condition, treatment or disease of the colon. Such as colonic enema, colonic ...Read more