Doctor insights on:
Hereditary Lysosomal Storage Diseases In Children
I was diagnosed with nephritis over 10 yrs ago. Is this hereditary? Will my children inherit this disease from me?
Depends on type: Nephritis means "inflammation of the kidney" and has many different causes including post streptococcal nephritis, lupes nephritis, membranoproliferative nephritis etc. None of the above are directly inherited. However there is a disease called "alports syndrome" that is inherited directly. You need to talk to your physician, find out what type of nephritis you had and have him/her advise you. ...Read more
Can hereditary rickets be prevented? My family has a genetic kidney disorder that causes rickets. Is it possible to take steps to prevent my children from getting rickets this way?
There : There are multiple kinds of kidney associated hereditary rickets that all have different patterns of inheritance. Many are "autosomal recessive" which means that the child must get an affected gene from each parent in order to have the disease. Some are x-linked which means that women carry the gene and men get the disease. The other type is "autosomal dominant" which means that you only need one gene to have the disease and that gene can come from either parent. The best thing to do is discuss your type of family rickets with your doctor. They may refer you to a genetic counselor to discuss the risk of your children in developing the disease. Prevention depends on what kind of rickets run in your family, your gender, whether you have the disease or are a carrier, and who the partner is with whom you want to have children. ...Read more
Autosomal recessive: Hurler syndrome (mucopolysaccharidosis type i) is a genetic condition. It is inherited in an autosomal recessive way. It means that both copies of the gene of a patient have a mutation (we have 2 copies of each gene, one from each parent). Parents of a patient each carry one copy of the mutated gene, and another healthy copy so they typically do not show signs and symptoms of the condition. ...Read more
They are synonyms: Congenital and hereditary essentially mean the same thing. ...Read more
Progeria: Little is known about it.Get a more detailed answer ›
Sex-linked: Way too long a list for this short format. So-called x-linked disorders (hemophilias, color-blindness) are generally inherited (expressed) in male offspring, while female offspring are carriers. Is there a specific disorder you are interested in? ...Read more
Vaccines : Full schedule of vaccines for the US can be found through the CDC. In brief: Children receive (not in this order): diphtheria, tetanus, pertussis, hepatitis A/B, strep pneumo, polio, hemophilus influenza type B, rotavirus, measles, mumps, rubella, varicella, meningococcus, influenza, human papilloma virus. Other vaccines available depending on travel or other circumstances. ...Read more
Yes: A coagulation defect changed world history. Queen Victoria passed it to her daughter Alice, who in turn passed it to Alexandra, wife of Czar Nicholas, whose son Alexii was a bleeder--and they fell under the influence of Rasputin, ignoring the affairs of state. Carrier women are not affected; their normal factor VIII gene on their other X-chromosome makes up for the abnormal gene. ...Read more
Sometimes: Some cases are due to a mutation carried by the mother. Most are due to spontaneous mutations or epigenetic events in the fertilized egg. So, the risk of Angelman may be inherited, but the disease may be genetic or due to epigenetic factors. It is one of the most complex genetic mechanisms yet discovered, and a clinical geneticist must analyze whether other family members are at up to 50% risk ...Read moreSee 1 more doctor answer
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