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Doctor insights on: Hereditary Colon Cancer Syndromes

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What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

Both inherited: In fap presents as colonic polyps ( gardners syn will have other tumors ) , autosomal recessive due to mutations in gate keeper, tumor suppres gene. On the contrary hnpcc or lynch syndrome. Is autosomal dominant, due to dna mismatch in repair, associated with other cancers of stomach, endomet. Ca, ovary, brain, skin etc. ...Read more

Dr. Barry Rosen
4,369 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Is colon cancer genetic?

Is colon cancer genetic?

Sometimes: Some colon cancers are related to specific genetic mutations but the majority are not. ...Read more

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Is bowel cancer hereditary?

Is bowel cancer hereditary?

Somehow yes: There is some genetic predisposition in families with hx. Of colorectal cancer. Diet also plays a rol ( low fiber diet increases cancer). Familiar poliposis increases chances of colon cancer. Colon polyps may degenerate in cancer. Small intestine cancers are rare and difficult to find. In general there are families affected by cancers and families affected by atherosclerosis but both together too. ...Read more

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Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca. ...Read more

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For what reason colon part is usually prone to cancer in hnpcc (hereditary hereditary nonpolyposis colorectal cancer)?

For what reason colon part is usually prone to cancer in hnpcc (hereditary hereditary nonpolyposis colorectal cancer)?

Genetic disorder: Hnpcc also called lynch syndrome results from at least four type of genetic defects involving genes needed for repair of damaged dna. See this site for more info. http://ghr.nlm.nih.gov/condition/lynch-syndrome. ...Read more

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Is bowel cancer genetic?

Is bowel cancer genetic?

Sometimes: Some colon cancers are related to inheritable genetic mutations but the majority are not. ...Read more

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Is rectal cancer hereditary?

Is rectal cancer hereditary?

Usually not : Most patients with rectal cancer have not inherited it. A small subset have genetic mutations that put them at risk. Probably around 5 % of rectal cancers are hereditary. ...Read more

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Is pancreatic cancer genetic?

Is pancreatic cancer genetic?

A minority is.: Pancreatic adenocarcinoma, arising from ducts/epithelial tissue, is mainly "sporadic", but can run in families. Pancreatic cancer has also been related to brca mutation, fammm syndrome, and some other inherited conditions. The familial pancreatic cancer registry is at johns hopkins. A minority of neuroendocrine tumors of the pancreas are associated with multiple endocrine neoplasia (men) syndromes. ...Read more

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Colorectal cancer causes?

Heredity & diet: The cause is not known in most cases. In a small number the cause is clearly heredity, e.g., apc and hnpcc. In the garden variety colon cancer, a diet low in fiber and rich in fats may increase the risk of cancer. ...Read more

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What genes cause hereditary ovarian cancer?

What genes cause hereditary ovarian cancer?

BRCA 1 and 2: The breast-ovarian cancer (brca 1 and 2) genes are the only ones so far proven to cause susceptibility to ovarian cancer (as high as 50% lifetime risk for ovarian, 85% for breast cancer if you have a mutation. Other ovarian cancer susceptibility genes may be identified by ongoing research. ...Read more

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Who should undergo genetic counseling for hereditary non-polyposis colorectal cancer (hnpcc)?

Who should undergo genetic counseling for hereditary non-polyposis colorectal cancer (hnpcc)?

Family history: There are a number of different inherited defects that cause hnpcc. A person with strong family history of colon cancer, occurring at a young age should seek counseling. ...Read more

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Is lung cancer hereditary?

Is lung cancer hereditary?

Unclear: Non or never smokers can develop lung cancer if they have a genetic mutation to such genes as egfr or eml4/alk fusion translocation. For more info: http://bit.Ly/ygfoko. ...Read more

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Are breast cancer and colon cancer linked?

Are breast cancer and colon cancer linked?

Not directly usually: There is debate about how closely these 2 cancers are related. Both have hereditary natures and are more common generally in obese patients. Both often begin with more benign precursor lesions like dcis for breast cancer and benign polyps for colon cancer. Both are very common but there is little evidence that having either predisposes to having the other. ...Read more

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Is ovarian cancer genetic?

Sometimes: Certain genotypes such as the brca mutations have a higher incidence of ovarian cancer. ...Read more

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Is bladder cancer hereditary?

No: Tobacco and environmental exposures to dyes for urothelial cancer; schistosoma hematobium, a parasite in egypt and chronic csatheterization for squamous cancr, and adenocarcinoma related to remnants of the urachus, the foetal conduit of urinary exretion through umbilicus into placental circulation...In this last case one might say "inborn error" but not genetic or hereditary. ...Read more

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Is the pancreatic cancer hereditary?

Is  the pancreatic cancer hereditary?

It may be hereditary: There is some evidence that pancreatic cancer may occur more in some families. Johns hopkins was doing a study on families with pancreatic cancer where by relatives were having very close followup that included ct scanning and surgery if there was suspicion of a developing cancer. I do not know if the study is still ongoing. ...Read more

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Is liver cancer hereditary?

It can be: Many factors can increase one's risk for primary liver cancer including: chronic infection with hepatitis b or c virus, type 2 diabetes, nonalcoholic fatty liver disease, heavy alcohol use, obesity, exposure to certain toxins, and inherited liver diseases that can lead to cirrhosis such as hemochromatosis, wilson's disease, tyrosinemia, Alpha 1-antitrypsin deficiency, glycogen, and porphyria. ...Read more

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How is colon cancer inherited?

How is colon cancer inherited?

Genes: Most colon cancers are not inherited. However, there is a subset which is associated with inherited genetic abnormalities such as hereditary polyposis a this hereditary non polyposis gene (hnpp). There are also syndromes that make you susceptible to a variety of different cancers including colon cancer such as lynch syndrome. ...Read more

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Is kidney cancer hereditary?

Is kidney cancer hereditary?

Sometimes: The vast majority of kidney cancer cases are not inherited (sporadic). There are a handful of syndromes known to be associated with different types of kidney cancer but they are rare. A well known example is von hippel-lindau syndrome. ...Read more

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How is familial adenomatous polyposis inherited?

How is familial adenomatous polyposis inherited?

Autosomal dominant: Enter omim in your browser and go to the database of all inherited diseases. Autosomal dominant means that affected individuals have one normal and one abnormal gene copy, the abnormal one dominating to cause disease. An affected person has a 50% chance to pass on the abnormal gene and fap with each pregnancy. ...Read more

Dr. Jan Rakinic
89 doctors shared insights

Hereditary Colon Cancer (Definition)

...include: familial adenomatous polyposis (FAP) and Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). In addition, some rare conditions – including attenuated familial adenomatous polyposis (AFAP) and MUTYH-associated ...Read more


Dr. Oscar Novick
13 doctors shared insights

Colon (Definition)

The colon is another term for the large intestine. This is the final portion of the digestive system, responsible for absorbing water and storing stool before evacuation. It is divided into sections described as cecum; ascending, transverse, descending and ...Read more