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Doctor insights on: Herceptin

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Dr. Debra Rosenblatt
65 doctors shared insights

Herceptin (Overview)

Herceptin is a cancer agent.


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What causes herceptin (trastuzumab) headache?

What causes herceptin (trastuzumab) headache?

Let me explain: The thoery is Herceptin (trastuzumab) infusion cause contious vasodilatation which is thought to provoke the headache. ...Read more

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Dr. Debra Rosenblatt
65 doctors shared insights

Herceptin (Overview)

Herceptin is a cancer agent.


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How exactly does herceptin (trastuzumab) work?

How exactly does herceptin (trastuzumab) work?

Blocks cell growth: Herceptin (trastuzumab) is a "monoclonal antibody". It is a protein that binds to receptors on breast cancer cells called her-2. Her-2 causes breast cancer cells to grow uncontrollably. When Herceptin (trastuzumab) binds to these cells, it slows their growth. However, not all breast cancer cells contain the her-2 receptors. Patients must be tested for the presence of her-2 receptors before they are started on herceptin (trastuzumab). ...Read more

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What are trastuzumab and herceptin?

What are trastuzumab and herceptin?

Biologic Therapy: Herceptin/trastuzumab is an antibody to a cell surface proteint coded for by the her2neu gene. Its present in some normal cells but in a subset of breast cancers (10-15%) there are multiple copies of the gene producing large amounts of the protein. The herceptin/trastuzumab antibody binds to that protein and reduces that aggressive nature of her2+cancer. It is usually given with chemo. ...Read more

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Can you tell me what are contraindications of herceptin (trastuzumab)?

None except...: There are no contraindications to this medication but it should not be used in pregnant women because of possible harm to the baby. ...Read more

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Is herceptin (trastuzumab) effective in treating bowel cancer?

Is herceptin (trastuzumab) effective in treating bowel cancer?

No: There is no evidence that Herceptin (trastuzumab) is useful in treating colon cancer. It' s use has been expanded to patients with metastatic esophageal and stomach cancers who over express the her2 protein ...Read more

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How does herceptin (trastuzumab) work?

How does herceptin (trastuzumab) work?

Binds to tumor: Herceptin (trastuzumab) is a man-made antibody that binds to cancer cells if they express the her2 receptor. It acts like "seasoning" for the immune system, attracting immune cells which kill the tumor cells. That's a simplistic explanation, because no one really understands what happens when Herceptin (trastuzumab) binds to tumor cells. There are many theories, but we know immune cells are necessary for it to work. ...Read more

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What should I do if I take too much herceptin (trastuzumab) by mistake?

Overdose is rare: Herceptin (trastuzumab) is what is referred to as a monoclonal antibody that is used to treat some types of cancer(breast, stomach). It is typically administered by IV in a controlled setting so overdose is rare. Although cardiac issues may arise in 2-7% of patients who recieve this, it does not appear to be dose related. An "accidental overdose" has not been shown to be detrimental. ...Read more

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Is having breathing problems while on herceptin (trastuzumab) due to breast cancer a normal side effect?

Is having breathing problems while on herceptin (trastuzumab) due to breast cancer a normal side effect?

Go to see oncologist: Breathing problem is not a normal side effect from herceptin (trastuzumab). Go to see your oncologist as soon as possible. Herceptin (trastuzumab) can affect your heart function and shortness of breath can be related to your heart condition. Other things like allergic reaction can happen-eventhough not common with herceptin (trastuzumab), also the cancer itself can give you the problem if it's causing fluid accumulation in the lung etc. ...Read more

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What are some common side effects of herceptin (trastuzumab)?

What are some common side effects of herceptin (trastuzumab)?

Flu-like: Most people do pretty well with herceptin, (trastuzumab) especially after the first few doses. Flu-like symptoms are common and you may have issues with your blood counts. Your oncologist will monitor these. Uncommonly, Herceptin (trastuzumab) can lead to diminished heart function or irregular heart beats. Your oncologist will check your heart before treatment and continue to monitor. ...Read more

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How long could herceptin (trastuzumab) stay in the body ?

About a week: Half life of 2 days. That means that half the blood level is gone in two days. Then, another 50% is gone in another two days, etc. ...Read more

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What are the effects of long term use of chemotherapy and herceptin (trastuzumab)?

What are the effects of long term use of chemotherapy and herceptin (trastuzumab)?

Eventual failure: Long term chemotherapy eventaully fails. In breast cancer there is a long term response but no cure. In her3neu patients there is a 3 month improvement but adding drugs like Taxol (paclitaxel) increases response to at least 8 months. ...Read more

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Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Up to 1 year's worth: Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). ...Read more

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What are trastuzumab and herceptin?

Biologic Therapy: Herceptin/trastuzumab is an antibody to a cell surface proteint coded for by the her2neu gene. Its present in some normal cells but in a subset of breast cancers (10-15%) there are multiple copies of the gene producing large amounts of the protein. The herceptin/trastuzumab antibody binds to that protein and reduces that aggressive nature of her2+cancer. It is usually given with chemo. ...Read more

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How does herceptin (trastuzumab) work?

Binds to tumor: Herceptin (trastuzumab) is a man-made antibody that binds to cancer cells if they express the her2 receptor. It acts like "seasoning" for the immune system, attracting immune cells which kill the tumor cells. That's a simplistic explanation, because no one really understands what happens when Herceptin (trastuzumab) binds to tumor cells. There are many theories, but we know immune cells are necessary for it to work. ...Read more

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Where can I buy herceptin(trastuzumab)?

Where can I buy herceptin(trastuzumab)?

Herceptin (trastuzumab) is : A medication that is typically given by an oncologist. Consult your doctor. ...Read more

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Where can you get herceptin (trastuzumab)?

Herceptin (trastuzumab): Herceptin (trastuzumab) is a prescription medication that prescribed by a medical oncologist for breast cancers that are HER2/neu positive or HER2/neu amplified. It is administered intravenously and is not available over the counter. ...Read more

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What is the cost of herceptin (trastuzumab)?

What is the cost of herceptin (trastuzumab)?

Thousands!: In the us, the cost of Herceptin (trastuzumab) depends on who gives it to you and what kind of insurance you have. Patient's bills are in the range of $2000 to over &7000 per treatment. Why the difference? Medicare limits how much the cost can be "marked up" from the purchase price, but other insurance companies aren't as strict. So... The cost is what the market will bear, sadly. ...Read more

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How exactly does herceptin (trastuzumab) work?

Blocks cell growth: Herceptin (trastuzumab) is a "monoclonal antibody". It is a protein that binds to receptors on breast cancer cells called her-2. Her-2 causes breast cancer cells to grow uncontrollably. When Herceptin (trastuzumab) binds to these cells, it slows their growth. However, not all breast cancer cells contain the her-2 receptors. Patients must be tested for the presence of her-2 receptors before they are started on herceptin (trastuzumab). ...Read more

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What are the effects of herceptin (trastuzumab)?

What are the effects of herceptin (trastuzumab)?

Killing cancer cells: Herceptin (trastuzumab) is an antibody, which is the y-shaped green thing in the picture. It sticks to the her2 protein which is present on some breast cancers (and other cancers). Herceptin (trastuzumab) seems to help the body's immune cells "see" and attack the cancer cells. For women with her2 positive breast cancer, it decreases the risk of the cancer returning by almost 50%! ...Read more

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Dr. Abraham Jaskiel
59 doctors shared insights

Trastuzumab (Definition)

Trastuzumab is an antibody based agent which is a kind of ...Read more