Doctor insights on:
Her2 Protein Breast Cancer
My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?
No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
It can be: Dcis, the earliest form of breast cancer, can be associated with brca mutations. 13% of women under 50 diagnosed with dcis had a brca mutation in retrospective (looking backwards) studies. Women with a family history of breast or ovarian cancer or dcis before age 50 should have genetic counseling. For more info: http://clincancerres.Aacrjournals.Org/content/13/14/4306.Full. ...Read moreSee 3 more doctor answers
Up to 1 year's worth: Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). ...Read moreSee 1 more doctor answer
What are the odds of having stage 2B invasive ductal carcinoma her2 positive breast cancer and papillary thyroid cancer at age 40?
Odds are low.: But it is still possible to have both. Risk of having papillary thyroid before forty is about 13/100,000. Risk of having breast Ca is about 11/100,000. The overlap of the two independent events is slightly less than 1 in a million. ...Read more
Stage IV: I hope your mom is okay. Metastatic breast cancer is condition when the cancer has spread beyond the breast. It commonly spreads to the liver, lung, bones, brain. It is unfortunately an incurable disease-although it is treatable. Therapy will depend on the biology of the cancer and your mother's overall health condition and her preference. We do have chemo, targetted therapy, hormonal therapy ...Read moreSee 1 more doctor answer
Is chemotherapy required for stage 1A IDC breast cancer, tumor size 1.1 cm, ER & PR positive, HER2 negative, nuclear grade 1. Patient is 42 years old.
Borderline call!: Your breast tumor is quite small, so it has >90% odds that it can be safely treated with surgery, without any chemotherapy required. You may ask your doctor for treating you with tamoxifen which is a antihormone type of medication, commonly used as the treatment for tumors that are ER positive. Good luck ...Read more
Herceptin (trastuzumab): The local treatment option (breast conservation versus mastectomy) are the same. The diff comes with systemic therapy. Her2+ cancers are more aggressive but this is counteracted by the biological (antibody) herceptin (trastuzumab). This is generally given with chemo. Since this is the case, it may often given before surgery (neoadj) to gain additional prognostic info and shrink the primary. ...Read moreSee 1 more doctor answer
Spread of cells: Micrometastasis means that a few tumor cells have left the breast tumor and traveled to the lymph nodes under the arm. In most cases, this is treated as a negative lymph node. I encourage you to review your pathology report with your surgeon and oncologists (ideally they are communicating with each other through a meeting called a tumor board). ...Read moreSee 3 more doctor answers
My mom had lobular breast cancer at 54 and her paternal cousin had breast cancer at 48. Everyone is brca negative. Is this likely hereditary?
Hard to tell...: ...without more info. BRCA 1 and 2 are not the only genes known to increase the risk for cancer and there are probably others we do not know anything about. Someone in the family (preferably your mom or her cousin) should visit a genetic counselor (if they have not yet done so) to see what other genes need to be tested if necessary and what else they can do to reduce their risk. ...Read more
In one word unknown : Ductal carcinoma in situ dcis is simply the sleeping cancer cells inside the breast ducts, like a garden hose loaded with cancer cells safe if they are inside the duct , once they are out side then is invasive cancer, ready to spread, cause is unknown at this time, from genetic mutations, braca i & ii age, hormonal uses.Environment , late age pregnancy life style etc are all attributed. ...Read moreSee 1 more doctor answer
Yes: Breast cancers can be highly variable from one person to the next. Cell types and dna evaluations can be performed now that can help direct the best treatments for each person. Her-2 breast cancers may be best treated with specialized chemotherapy agent heceptin. ...Read moreSee 1 more doctor answer
Unknown??: By definition, "alternative" is different than modern western medicine. Generally any drug, herb, treatment, that stands up to rigorous scientific scrutiny is included in modern medicine. The problem is that many alternative practices, herbs etc do not stand up to scientific scrutiny and cannot be shown to work. And can not be proven SAFE. Be careful save ur $$$ see : http://nccam.Nih.Gov ...Read moreSee 1 more doctor answer
It is curable.: All breast cancer is bad, but the prognosis changes with stages. So the lowest stage has the best prognosis and the highest stage, stage 4, has the worst prognosis. Technically there is a stage 0 which is something called dcis, which hasn't invaded out of the ducts. Stage 1 is better than stage 2 but stage 2 is definitely curable. You can never know you are cured for sure so follow up is necessary. ...Read more
Yes: Tamoxifen is an antiestrogen that blocks the ability of breast cancer cells to use estrogen; therefore, it is only effective in hormone sensitive (estrogen receptor +) breast cancers. When taken for 5 years, tamoxifen has been shown to both stop the growth of cancer cells in breast cancer patients and to prevent the development of breast cancer in women that are at high risk. ...Read moreSee 1 more doctor answer
Surgeon said occult breast cancer spread to 2lymp nodes under arm no sign cancer in breast .Surgeon advises take out lymph glands, live breast .Should ?
Standard treatment: The surgeon is giving you the "best evidence" advice. Without detecting any tumor in the breast, it is safer, less mutilating, less painful, less expensive, and better psychologically to leave the breast in place. Usually the tumor is so tiny that it cannot be found. Often, chemotherapy (to kill any cancer cells elsewhere in the body) and radiation to the breast is done. Good luck! ...Read moreSee 3 more doctor answers
Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more
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