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Doctor insights on: Her2 Positive Metastatic Breast Cancer

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Chemotherapy hormone receptor positive node breast cancer?

Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

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Dr. Barry Rosen
4,344 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Anyone have stage 1 breast cancer with her2/neu positive er/pr negative?

Anyone have stage 1 breast cancer with her2/neu positive er/pr negative?

Yes: Breast cancers can be highly variable from one person to the next. Cell types and dna evaluations can be performed now that can help direct the best treatments for each person. Her-2 breast cancers may be best treated with specialized chemotherapy agent heceptin. ...Read more

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O had surgery for positive breast cancer. Is sentinel lymph node biopsy accurate for breast cancer surgery. Node was negative.

O had surgery for positive breast cancer. Is sentinel lymph node biopsy accurate for breast cancer surgery. Node was negative.

Yes they are: by now sentinel lymph node are the standard of care for breast cancer surgery and staging, and yes they are very accurate. node is negative is a very good news that will make the cancer early stage and hopefully cureable ...Read more

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Could breast cancer usually metastasize?

Could breast cancer usually metastasize?

Possible: Breast cancer can metastasize. The risk is really dependent on the stage. For a stage i, the risk is. ...Read more

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My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more

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Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Up to 1 year's worth: Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). ...Read more

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Tell me the metastatic triple negative breast cancer survival rates?

Tell me the metastatic triple negative breast cancer survival rates?

Depends: Survival rates depend on multiple factors; age, response to treatment, stage of disease, your overall health. This is a conversation best had with your medical oncologist. ...Read more

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What is breast cancer sentinel node micro metastases?

What is breast cancer sentinel node micro metastases?

Spread of cells: Micrometastasis means that a few tumor cells have left the breast tumor and traveled to the lymph nodes under the arm. In most cases, this is treated as a negative lymph node. I encourage you to review your pathology report with your surgeon and oncologists (ideally they are communicating with each other through a meeting called a tumor board). ...Read more

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Metastatic breast cancer usually spread to liver?

It may: Breast cancer can metastascise to many organs. Regionally to the lymph nodes and distantly to other organs. More commonly to the bones, lung, liver, brain and other visceral structures in the abdomen or pelvis. ...Read more

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What is the her2- positive breast cancer survival rate?

What is the her2- positive breast cancer survival rate?

Very high!: The five year survival rate for all breast cancer is over 90%. Her2+ cancers used to have the worst prognosis, but Herceptin (trastuzumab) changed that. Now they have a very good prognosis if they are caught at an early stage (stage 1 or 2). The stage really determines the prognosis, so without that information i can't give you a number. But I am happy for my patients with a her2+ cancer-- many treatments! ...Read more

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Treatment for her2 breast cancer?

Treatment for her2 breast cancer?

Herceptin (trastuzumab): The local treatment option (breast conservation versus mastectomy) are the same. The diff comes with systemic therapy. Her2+ cancers are more aggressive but this is counteracted by the biological (antibody) herceptin (trastuzumab). This is generally given with chemo. Since this is the case, it may often given before surgery (neoadj) to gain additional prognostic info and shrink the primary. ...Read more

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Is dcis breast cancer genetic?

Is dcis breast cancer genetic?

It can be: Dcis, the earliest form of breast cancer, can be associated with brca mutations. 13% of women under 50 diagnosed with dcis had a brca mutation in retrospective (looking backwards) studies. Women with a family history of breast or ovarian cancer or dcis before age 50 should have genetic counseling. For more info: http://clincancerres.Aacrjournals.Org/content/13/14/4306.Full. ...Read more

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Abdominal carcinamatosis from breast cancer metastasis?

Abdominal carcinamatosis from breast cancer metastasis?

Could Be: You have a known breast ca? Any other mets? Typically, one would expect mets to bone before abdomen. If pathology on both sites is the same then probably mets. If not, possible second primary (like ovary). Good luck. ...Read more

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32 YO, triple positive, grade 3, stage 1B breast cancer. TCH chemotherphy, had dbl mastectomy. What is survival rate?

Need Clarification!: Are you sure your breast cancer was triple positive(or was it triple Negative)??? TCH is commonly used chemotherapy for triple negative, so please double check and let us know. Then we can give you survival figures. In general, small tumors(Stage 1 and stage 2) have very good survival rate and high cure rates. ...Read more

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Is chemotherapy required for stage 1A IDC breast cancer, tumor size 1.1 cm, ER & PR positive, HER2 negative, nuclear grade 1. Patient is 42 years old.

Is chemotherapy required for stage 1A IDC breast cancer, tumor size 1.1 cm, ER & PR positive, HER2 negative, nuclear grade 1. Patient is 42 years old.

Borderline call!: Your breast tumor is quite small, so it has >90% odds that it can be safely treated with surgery, without any chemotherapy required. You may ask your doctor for treating you with tamoxifen which is a antihormone type of medication, commonly used as the treatment for tumors that are ER positive. Good luck ...Read more

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What is ductal incarcinoma (breast cancer )?

What is ductal incarcinoma (breast cancer )?

Breast Cancer: Learn more about intraductal carcinoma of the breast at: http://www.Intraductalcarcinoma.Net/. ...Read more

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Metastatic breast cancer has gone to hip bone; prognosis?

Metastatic breast cancer has gone to hip bone; prognosis?

This depends: The answer depends on many factors. How old is the persone, what other medical problems do they have, when did the breast cancer first occur, what other sites are involved, what are the characteristics of the cancer (estrogen, Progesterone receptors, her2/neu status) and what prior treatments were administered are some of the issues that factor into an answer. ...Read more

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What are the odds of having stage 2B invasive ductal carcinoma her2 positive breast cancer and papillary thyroid cancer at age 40?

What are the odds of having stage 2B invasive ductal carcinoma her2 positive breast cancer and papillary thyroid cancer at age 40?

Odds are low.: But it is still possible to have both. Risk of having papillary thyroid before forty is about 13/100,000. Risk of having breast Ca is about 11/100,000. The overlap of the two independent events is slightly less than 1 in a million. ...Read more

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My mom has metastatic breast cancer ?

My mom has metastatic breast cancer ?

Stage IV: I hope your mom is okay. Metastatic breast cancer is condition when the cancer has spread beyond the breast. It commonly spreads to the liver, lung, bones, brain. It is unfortunately an incurable disease-although it is treatable. Therapy will depend on the biology of the cancer and your mother's overall health condition and her preference. We do have chemo, targetted therapy, hormonal therapy ...Read more

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What is metastatic breast cancer?

What is metastatic breast cancer?

Spread : This means that the cancer has spread to other areas outside of the breast. This is known as stage 4. With the use of modern chemotherapy, this disease can be controlled. I recommend you meet with your medical oncologist to determine options available for treatment. ...Read more

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How can metastatic breast cancer progress?

How can metastatic breast cancer progress?

It can and it does: Progress of cancer means the cancer is getting worse. This is not uncommon as the cancers tend to spead further in the body and tumors get larger in size especially when the treatment is not working. Cancer is either regressing(with good treatment) or progressing(without treatment or with the ineffective treatment). ...Read more

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What does metastatic breast cancer really mean?

What does metastatic breast cancer really mean?

Cancer has spread: Metastatic, or stage 4 breast cancer, means the cancer has spread into other places in the body. Breast cancer at this stage can be treated, sometimes for 10 or more years depending on the type, but it cannot be cured. ...Read more

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Why is metastatic breast cancer difficult to treat?

Why is metastatic breast cancer difficult to treat?

It's not: There are many treatments for metastatic breast cancer which can control it for years. Although it can be treated, it is rarely cured. That is because cancer cells are constantly mutating, so treatments lose effectiveness. Metastatic breast cancer requires constant treatment with either hormone therapy, chemotherapy, or biologic therapy. Treatments are changed as they lose effectiveness. ...Read more

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What's a natural way to treat metastatic breast cancer?

What's a natural way to treat metastatic breast cancer?

None: My sympathies for your condition. There is nothing in the medicine cabinet of natural medicine for metastatic breast cancer. A variety of agents are helpful in this condition which your oncologist can help you with. ...Read more

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Can you tell me what exactly is metastatic breast cancer?

Can you tell me what exactly is metastatic breast cancer?

Stage 4 cancer: There are 4 stages of cancer, with stage 4 being the highest. Stage 4 means cancer has spread outside of the place it started and can't be removed by surgery. Women with stage 4, or metastatic, breast cancer cannot usually be cured. The cancer can be treated to keep it under control, often for years, but it depends on the type of breast cancer. ...Read more

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What is the definition or description of: Metastatic breast cancer?

What is the definition or description of: Metastatic breast cancer?

Distant spread: Cancer that has spread from its origin (breast) to any other location (lymph nodes, bones, organs, etc.) outside of the primary site. ...Read more

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In Metastatic Breast Cancer what does elevated ESR mean?

In Metastatic Breast Cancer what does elevated ESR mean?

Not much: It is a non specific test which means it can increase in all kinds of ailments such as chronic infections(TB for example and in Chronic arthritis) and in many different Cancers. So it is not useful test for Breast Cancer....pure waste of money! ...Read more

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Metastatic breast cancer what is survival rate women older than 65?

Depends....: ...on many factors, such as ER and Her2 status (+ vs. -), tumor grade, how many metastases (a few vs. a lot), the location of the metastases (bone vs. liver/lung/brain), the general health of the patient, and the availability of therapy for her. I would say that as a rule, metastatic breast cancer patients do better than other common cancers but of course there are exceptions. Saludos. ...Read more

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What is the survival rate of metastatic breast cancer to other organs?

What is the survival rate of metastatic breast cancer to other organs?

Highly variable: Everyone is different, responds to treatments differently, has different cell types & different underlying medical conditions. Depends if bone or lung or liver involvement. Some patients can live for years & others may not. The patient's treating oncologist would be able to answer much better. ...Read more

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What to do if I have triple negative metastatic breast cancer stage iv?

What to do if I have triple negative metastatic breast cancer stage iv?

Don't give up: For starters, find a good oncologist, preferably one who works within a multidisciplinary team and has access to clinical trials. There are too many variables to give you specifics but very likely you will be offered chemo. Depending on the circumstances, surgery or radiation may come to play. You had 3x- cancer before age 60 and fulfill criteria for BRCA testing. If positive (or even if not)... ...Read more

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Can you tell me what is the life expectancy of metastatic breast cancer?

Can you tell me what is the life expectancy of metastatic breast cancer?

It depends: There are many types of metastatic breast cancer. Life expectancy depends on the type and the location. Er+ breast cancer that has spread only to bones has a life expectancy of years, even 5-10 years. Er- breast cancer has a much shorter life expectancy. In general, breast cancer in organs (lung, liver, brain) causes death sooner than breast cancer in bones only. Ask your oncologist. ...Read more

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If you have metastatic breast cancer can you have surgery to remove the breast?

If you have metastatic breast cancer can you have surgery to remove the breast?

Surgery needed: Even inn face of metastatic disease removal of primary eliminales clones that can metastasize ot other sites. Once primary is gone, proper therapy, whether RT alone or in combination with chemo and hormone therapy an be decided upon. ...Read more

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What is a survival rate of women older than 60 who have metastatic breast cancer?

What is a survival rate of women older than 60 who have metastatic breast cancer?

Variable: Stage 4 metastatic breast cancer can be controlled with chemotherapy in some. Some can live years depending on the individual's response to chemotherapy treatments. Others will not do as well, and each person is different. Discuss in more detail with the treating medical oncologist who can give better answers, knowing the patient and the specific details of the breast cancer. ...Read more

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What are signs that someones body is shutting down due to stage 4 metastatic breast cancer?

It varies: Advanced cancers lead to increasing impairment of mobility due to weakness, loss of weight or organ failure. Your doctor can help you more by checking the patient.And the reports of their burden of cancer. Anyone who is eating well and fully mobile, is not close to 'shuting down'. ...Read more

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If one has slow-growing metastatic breast cancer will the anti-cancer drugs make the cancer more aggressive?

Treatment: Does not alter biologic behavior. Mets are never good. Some argue to re-biopsy to recheck re-ceptors (er, pr her-2-neu): the cells that metastasize may be different from those at outset. Best gauge is time from DX to relapse for "slow". Bony only and er+ usually fit this pattern. Cytotoxic chemo does not change growth or met potential, but cancers themselves can mutate to more aggressive type. ...Read more

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Had holiday gathering with multiple family members and found out that many had metastatic breast cancer. What can I do to prevent it?

Had holiday gathering with multiple family members and found out that many had metastatic breast cancer. What can I do to prevent it?

Genetic testing: Yes, i agree with dr turrisi and zafar. Talk to your family members who have breast cancer. They would need to have genetic counselling and genetic testing - to see if they carry the brca 1/2 gene mutation etc. If they carry this gene mutation, then you should ask the counsellor what your risk is and then you would probably need to get the test as well. You need prevention if your test is +. ...Read more

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My relative has metastatic breast cancer, going through the final stages. Is it advisable for her daughter to undergo tests? Is cancer hereditary?

My relative has metastatic breast cancer, going through the final stages. Is it advisable for her daughter to undergo tests? Is cancer hereditary?

Yes, some forms of: Breast cancer are hereditary. It's best to ask your relative's doctor what if she had the genetic type of breast cancer. If your relative got it at a fairly young age, it is definitely advisable for her daughter to get genetic testing. ...Read more

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How effectice is Xeloda (capecitabine) for metastatic breast cancer?

Quite effective: Xeloda (capecitabine) is quite an effective drug and has been used in metastatic breast cancer. The response will be higher when it is combined with other chemotherapy agent- with additional possible side effects. Discuss further with you oncologist in detail. ...Read more

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What is metastatic breast cancer?

Spread : This means that the cancer has spread to other areas outside of the breast. This is known as stage 4. With the use of modern chemotherapy, this disease can be controlled. I recommend you meet with your medical oncologist to determine options available for treatment. ...Read more

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What exactly is metastatic breast cancer?

What exactly is metastatic breast cancer?

Stage 4 Cancer: Metastatic breast cancer is cancer that started in the breast, but has spread into other places like the liver, lung, bones or brain. It is also called stage 4 breast cancer. It is not usually curable, but many women live with metastatic breast cancer for years with ongoing treatment. ...Read more

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Dr. Barry Rosen
1,378 doctors shared insights

Breast Cancer (Definition)

Occurs when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. Often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


Dr. Mark Hoepfner
1,061 doctors shared insights

Breast Carcinoma (Definition)

Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more