Doctor insights on:
Her2 Positive Breast Cancer Prognosis
Which is easier to cure a breast cancer who is a pr/er positive and her2 negative or er/pr negative and her2 positive? Who has longer prognosis?
ER positive: In general, er+ has better prognostic features. However, the entire picture has to be evaluated (tumor size, lymph node involvement, distant spread) in order to determine prognosis for you. A big factor is individual biology. Tumors are different in different people, different ages and even ethnicities. Focus on following your prescribed treatment regimen and thinking positive. ...Read moreSee 1 more doctor answer
Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more
Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?
Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more
Very high!: The five year survival rate for all breast cancer is over 90%. Her2+ cancers used to have the worst prognosis, but Herceptin (trastuzumab) changed that. Now they have a very good prognosis if they are caught at an early stage (stage 1 or 2). The stage really determines the prognosis, so without that information i can't give you a number. But I am happy for my patients with a her2+ cancer-- many treatments! ...Read more
Lump : Her2 cancers may tend to grow and spread faster than Her2 negative cancers. There are also specific medicines that can be used with Her2 positive cancers. However, there are really no symptoms specific for a Her2 cancer. Like all early stage cancers, there may be no symptoms(and the cancer is detected on mammogram or ultrasound), or there may be a palpable mass. ...Read moreSee 2 more doctor answers
Her2-positive breast cancer stage 1 level 3 and 70 yrs old - how much longer can somebody expect to live?
A full lifetime: Stage 1 cancer is curable with appropriate treatment. With surgery to remove the tumor, and appropriate chemotherapy including herceptin, (trastuzumab) the chance of cure is very high. In someone age 70, the doses of chemo drugs might need to be reduced, but Herceptin (trastuzumab) is not chemo. Older people do well on it! it is very unlikely she will die from breast cancer if she gets good treatment now. ...Read more
What are the odds of having stage 2B invasive ductal carcinoma her2 positive breast cancer and papillary thyroid cancer at age 40?
Odds are low.: But it is still possible to have both. Risk of having papillary thyroid before forty is about 13/100,000. Risk of having breast Ca is about 11/100,000. The overlap of the two independent events is slightly less than 1 in a million. ...Read more
Aggressive: HER2 is a gene present in many cells that sends control signals causing the cells to grow, divide, and make repairs. A normal breast cell has 2 copies of the HER2 gene. Certain breast cancers start when a cell has more than 2 copies of that gene, and start over-producing the HER2 protein. The involved tumor cells grow and divide more quickly. These tumor cells are sensitive to Herceptin (trastuzumab). ...Read more
Better.: HER2 receptor testing (along with estrogen and progesterone receptor testing) is done on breast cancer tissue to help guide the oncologist for endocrine chemotherapy. It's better if tissues are positive in each case as this increases the treatment choices. If all three are negative (triple negative breast cancer), the prognosis for cure is diminished. ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
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