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Doctor insights on: Her2 Breast Cancer Prognosis

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Dr. Barry Rosen
1,337 doctors shared insights

Breast Cancer (Definition)

Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


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Which is easier to cure a breast cancer who is a pr/er positive and her2 negative or er/pr negative and her2 positive? Who has longer prognosis?

Which is easier to cure a breast cancer who is a pr/er positive and her2 negative or er/pr negative and her2 positive? Who has longer prognosis?

ER positive: In general, er+ has better prognostic features. However, the entire picture has to be evaluated (tumor size, lymph node involvement, distant spread) in order to determine prognosis for you. A big factor is individual biology. Tumors are different in different people, different ages and even ethnicities. Focus on following your prescribed treatment regimen and thinking positive. ...Read more

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Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more

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What does it mean if I tested HER2-positive for breast cancer?

What does it mean if I tested HER2-positive for breast cancer?

Aggressive: HER2 is a gene present in many cells that sends control signals causing the cells to grow, divide, and make repairs. A normal breast cell has 2 copies of the HER2 gene. Certain breast cancers start when a cell has more than 2 copies of that gene, and start over-producing the HER2 protein. The involved tumor cells grow and divide more quickly. These tumor cells are sensitive to Herceptin (trastuzumab). ...Read more

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Is her2 better if negative or positive in regards to breast cancer?

Is her2 better if negative or positive in regards to breast cancer?

Better.: HER2 receptor testing (along with estrogen and progesterone receptor testing) is done on breast cancer tissue to help guide the oncologist for endocrine chemotherapy. It's better if tissues are positive in each case as this increases the treatment choices. If all three are negative (triple negative breast cancer), the prognosis for cure is diminished. ...Read more

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What is the function of HER2/neu and how is it related to breast cancer?

What is the function of HER2/neu and how is it related to breast cancer?

Growth signal: Her2 is a receptor on the surface of some breast cancers. It is like a light switch that tells the cancer to grow. Breast cancer cells that have many Her2 receptors have the light switch always turned on, telling the cells to grow. Fortunately, newer drugs block the receptor, turning off the growth switch and making these cancers very treatable. ...Read more

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Is her2 positive or her2 negative better when dealing with breast cancer?

Time will tell: Her 2 over expressed breast cancer is considered to be more aggressive and have a higher risk of recurring. That being said, there are many more targeted agents which make this type of breast cancer more treatable and curable. ...Read more

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Treatment for her2 breast cancer?

Treatment for her2 breast cancer?

Herceptin (trastuzumab): The local treatment option (breast conservation versus mastectomy) are the same. The diff comes with systemic therapy. Her2+ cancers are more aggressive but this is counteracted by the biological (antibody) herceptin (trastuzumab). This is generally given with chemo. Since this is the case, it may often given before surgery (neoadj) to gain additional prognostic info and shrink the primary. ...Read more

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What is the her2- positive breast cancer survival rate?

What is the her2- positive breast cancer survival rate?

Very high!: The five year survival rate for all breast cancer is over 90%. Her2+ cancers used to have the worst prognosis, but Herceptin (trastuzumab) changed that. Now they have a very good prognosis if they are caught at an early stage (stage 1 or 2). The stage really determines the prognosis, so without that information i can't give you a number. But I am happy for my patients with a her2+ cancer-- many treatments! ...Read more

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What do ER and her2 positive mean in relation to breast cancer?

What do ER and her2 positive mean in relation to breast cancer?

Receptor Status: The er positive refers to the receptor status of the breast cancer. This means that the tumor has receptors to estrogen and that anti-estrogen therapy can be used to slow the growth of the tumor. Her2 is a another receptor that is a target of a chemotherapeutic agent called herceptin (trastuzumab). ...Read more

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Dr. Barry Rosen
4,224 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


Prognosis (Definition)

The prognosis is the predicted outcome or "forecast" for a disease or process. It is only an estimate but is likely based on past experience or data taking into account the individual's overall health status. It may suggest progression of disease ...Read more