Top
20
Doctor insights on: Her2 Amplification Breast Cancer

Share
1

1
My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

My mom had lobular breast cancer at 52. Brca negative. Is lobular breast cancer more genetic based than ductal?

No its medullary: a quote from Lancethttp://www.ncbi.nlm.nih.gov/pubmed/9167459: "The occurrence of invasive lobular carcinoma and invasive ductal carcinoma was not significantly different between carriers of BRCA1 or BRCA2 mutations and controls. Medullary or atypical medullary carcinoma was, however, found more often in BRCA1 (13%, p ...Read more

Dr. Barry Rosen
4,404 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


2

2
Is dcis breast cancer genetic?

Is dcis breast cancer genetic?

It can be: Dcis, the earliest form of breast cancer, can be associated with brca mutations. 13% of women under 50 diagnosed with dcis had a brca mutation in retrospective (looking backwards) studies. Women with a family history of breast or ovarian cancer or dcis before age 50 should have genetic counseling. For more info: http://clincancerres.Aacrjournals.Org/content/13/14/4306.Full. ...Read more

See 3 more doctor answers
3

3
Anyone have stage 1 breast cancer with her2/neu positive er/pr negative?

Anyone have stage 1 breast cancer with her2/neu positive er/pr negative?

Yes: Breast cancers can be highly variable from one person to the next. Cell types and dna evaluations can be performed now that can help direct the best treatments for each person. Her-2 breast cancers may be best treated with specialized chemotherapy agent heceptin. ...Read more

See 1 more doctor answer
4

4
What distinguishes inflammatory breast cancer from invasive breast cancer?

What distinguishes inflammatory breast cancer from invasive breast cancer?

Inflammatory breast: Cancer is a subtype of invasive breast cancer that involves the skin. It causes the skin to appear inflamed. ...Read more

See 1 more doctor answer
5

5
O had surgery for positive breast cancer. Is sentinel lymph node biopsy accurate for breast cancer surgery. Node was negative.

O had surgery for positive breast cancer. Is sentinel lymph node biopsy accurate for breast cancer surgery. Node was negative.

Yes they are: by now sentinel lymph node are the standard of care for breast cancer surgery and staging, and yes they are very accurate. node is negative is a very good news that will make the cancer early stage and hopefully cureable ...Read more

6

6
What is ductal incarcinoma (breast cancer )?

What is ductal incarcinoma (breast cancer )?

Breast Cancer: Learn more about intraductal carcinoma of the breast at: http://www.Intraductalcarcinoma.Net/. ...Read more

7

7
What is breast cancer sentinel node micro metastases?

What is breast cancer sentinel node micro metastases?

Spread of cells: Micrometastasis means that a few tumor cells have left the breast tumor and traveled to the lymph nodes under the arm. In most cases, this is treated as a negative lymph node. I encourage you to review your pathology report with your surgeon and oncologists (ideally they are communicating with each other through a meeting called a tumor board). ...Read more

See 3 more doctor answers
8

8
My mom had lobular breast cancer at 54 and her paternal cousin had breast cancer at 48. Everyone is brca negative. Is this likely hereditary?

My mom had lobular breast cancer at 54 and her paternal cousin had breast cancer at 48. Everyone is brca negative. Is this likely hereditary?

Hard to tell...: ...without more info. BRCA 1 and 2 are not the only genes known to increase the risk for cancer and there are probably others we do not know anything about. Someone in the family (preferably your mom or her cousin) should visit a genetic counselor (if they have not yet done so) to see what other genes need to be tested if necessary and what else they can do to reduce their risk. ...Read more

9

9
Treatment for her2 breast cancer?

Treatment for her2 breast cancer?

Herceptin (trastuzumab): The local treatment option (breast conservation versus mastectomy) are the same. The diff comes with systemic therapy. Her2+ cancers are more aggressive but this is counteracted by the biological (antibody) herceptin (trastuzumab). This is generally given with chemo. Since this is the case, it may often given before surgery (neoadj) to gain additional prognostic info and shrink the primary. ...Read more

See 1 more doctor answer
Dr. Liawaty Ho Dr. Ho
6 doctors agreed:
10

10
Does breast pain signal breast cancer?

Dr. Liawaty Ho Dr. Ho
6 doctors agreed:
Does breast pain signal breast cancer?

Not common: Breast pain although can be part of presentation of breast cancer- however, it is not a common sign of breast cancer. Many things can give breast pain including- cyclical changes ( hormonal changes related to period), hormonal imbalance, fibrocystic disease of the breast, inflammation, infection/abscess, caffeine, trauma, large breast size with a poor bra support etc, all can give you breast pain. ...Read more

See 2 more doctor answers
11

11
Does male breast cancer have different symptoms from female breast cancer?

Does male breast cancer have different symptoms from female breast cancer?

Not really: Most breast cancers are without symptoms. That is why many are missed. Males having such little breast tissue may notice a lump earlier but not always so many go undetected because few realize that men are also susceptible to breast cancer. ...Read more

See 2 more doctor answers
12

12
Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Up to 1 year's worth: Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). ...Read more

See 1 more doctor answer
13

13
32 YO, triple positive, grade 3, stage 1B breast cancer. TCH chemotherphy, had dbl mastectomy. What is survival rate?

32 YO, triple positive, grade 3, stage 1B breast cancer. TCH chemotherphy, had dbl mastectomy.  What is survival rate?

Need Clarification!: Are you sure your breast cancer was triple positive(or was it triple Negative)??? TCH is commonly used chemotherapy for triple negative, so please double check and let us know. Then we can give you survival figures. In general, small tumors(Stage 1 and stage 2) have very good survival rate and high cure rates. ...Read more

14

14
What is the her2- positive breast cancer survival rate?

What is the her2- positive breast cancer survival rate?

Very high!: The five year survival rate for all breast cancer is over 90%. Her2+ cancers used to have the worst prognosis, but Herceptin (trastuzumab) changed that. Now they have a very good prognosis if they are caught at an early stage (stage 1 or 2). The stage really determines the prognosis, so without that information i can't give you a number. But I am happy for my patients with a her2+ cancer-- many treatments! ...Read more

15

15
Breast cancer stage 1b with 1/3 lymph node micrometastasis at 1.9. Left breast, pt 32y. Radiation therapy controversial. Need opinions?

Breast cancer stage 1b with 1/3 lymph node micrometastasis at 1.9.  Left breast, pt 32y.  Radiation therapy controversial.  Need opinions?

Surgery?: would need radiation if surgical treatment was lumpectomy. Patient is young and need further evaluation with detailed family history. Estrogen and HER2neu receptor status, ki 67 would help to make better treatment decision. ...Read more

16

16
Twin sister has breast cancer. Says she has ductal AND lobular cancer. Surgery,chemo,radiation And hormone therapy after. Prognosis for this type?

Twin sister has breast cancer. Says she has ductal AND lobular cancer. Surgery,chemo,radiation And hormone therapy after. Prognosis for this type?

Prognosis is Stage-b: The prognosis of breast Cancer is dependent on stage of her Cancer at the time of diagnosis. Most breast cancers are stage-1 or 2 and patients do very well, living near normal lives. Check in case she had stage-3 cancer....which does carry risk for recurrence in the future. I think she will do well over the next 5-10 years but needs to remain under surveillance as there is always some unpredictabi ...Read more

Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
17

17
Chemotherapy hormone receptor positive node breast cancer?

Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

See 2 more doctor answers
18

18
Breast cancer:mastectomy done;1/12 affedctes nodes; positive hormonal receiver; score0;stage 2; is there a possibility to have a breast cancer again?

Possible...: It all depends on the pathology report (her2 status..) and treatment provided. No guarantees in life but ! not knowing all the details, she has at least more than 60% chance of cure. Be postive. Encourage her, continue hormonal teatement for at least 5 years. Discuss the case with the oncologist who has all the information and treatment in front of him. Do not be shy. Thanks for asking. ...Read more

See 1 more doctor answer
19

19
Is chemo required for an invasive carsinoma in situ stage 1b grade 2, 0.8 CM in size mastec done, fibroadipose and breast tissue, sentinel lymph clear?

Is chemo required for an invasive carsinoma in situ stage 1b grade 2, 0.8 CM in size mastec done, fibroadipose and breast tissue, sentinel lymph clear?

Maybe: With a node negative cancer. { i don't understand the invasive and in situ as they are apposite. } current recommendations are for genomic testing to see if the tumor has a high or low risk of recurrence. ...Read more

20

20
Could breast cancer usually metastasize?

Could breast cancer usually metastasize?

Possible: Breast cancer can metastasize. The risk is really dependent on the stage. For a stage i, the risk is. ...Read more

Dr. Mark Hoepfner
1,068 doctors shared insights

Breast Carcinoma (Definition)

Most breast cancers are carcinomas. This is a type of breast cancer. These cancers start in the cells that line organs and tissues. In fact, breast cancers are often a type of carcinoma called adenocarcinoma, which starts in cells that make glands (glandular tissue). Breast adenocarcinomas start in the ducts (the milk ducts) or ...Read more


Dr. Barry Rosen
1,391 doctors shared insights

Breast Cancer (Definition)

A condition in which cells lining the inside of the breast grow ...Read more